Cheng Zhu, PhD, MS
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Research Program
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Phone Number
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Email Address
Biography
Cheng Zhu, PhD, MS, is the J. Erskine Love Jr. Endowed Chair in Engineering Regents' Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech School of Engineering and Emory University School of Medicine. Dr. Zhu is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. Dr. Zhu received his PhD and his MS from Columbia University in New York, New York.Education
Titles & Roles
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J. Erskine Love Jr. Endowed Chair in Engineering Regents' Professor, Wallace H. Coulter Department of Biomedical EngineeringGeorgia Institute of Technology and Emory University
Research
The goal of Dr. Zhu's research is to gain a fundamental understanding of important biological processes at the level of cells and molecules, and their relations to human health and diseases. Current research projects in the Zhu lab focus on the adhesion and signaling molecules in the immune system and the vascular system. The experiments utilize state-of-the-art technologies, including micropipette manipulation, atomic force microscopy, biomembrane force probe, and real-time laser scanning confocal microscopy.
Grants
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Grant Number Title 2R01HL132019-05 Mechanotransduction of platelet receptors GPIb and GPIIb-IIIa 3U01CA250040-02S1 Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy 3U01CA250040-03S1 Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy 3U01CA250040-04S1 Bispecific molecules linking T cell receptor and tumor antigen for cancer immunotherapy 3U01CA250040-04S2 Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy 5R01HL132019-06 Mechanotransduction of platelet receptors GPIb and GPIIb-IIIa 5R01HL132019-07 Mechanotransduction of platelet receptors GPIb and GPIIb-IIIa 5U01CA250040-03 Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy 5U01CA250040-04 Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy Title/Journal Authors Publication Date Zebrafish
CJ Krueger, Z Dai, C Zhu, B Zhang 20/03/2024 Nature communications
X Hua, K Han, B Mandracchia, A Radmand, W Liu, H Kim, Z Yuan, SM Ehrlich, K Li, C Zheng, J Son, AD Silva Trenkle, GA Kwong, C Zhu, JE Dahlman, S Jia 04/03/2024 Human molecular genetics
JP Allen, KB Garber, R Perszyk, CT Khayat, SA Kell, M Kaneko, C Quindipan, S Saitta, RL Ladda, S Hewson, M Inbar-Feigenberg, C Prasad, AN Prasad, L Olewiler, W Mu, LS Rosenthal, M Scala, P Striano, F Zara, TW McCullock, RT Jauss, JR Lemke, DM MacLean, C Zhu, H Yuan, SJ Myers, SF Traynelis 01/02/2024 Force-Regulated Spontaneous Conformational Changes of Integrins α5β1 and αVβ3.
ACS nano
Y Chen, Z Li, F Kong, LA Ju, C Zhu 09/01/2024 iScience
S Liu, ZC Liu, MY Zhang, SJ Wang, M Pan, P Ji, C Zhu, P Lin, Y Wang 15/12/2023 Mechanical force regulates ligand binding and function of PD-1.
bioRxiv : the preprint server for biology
K Li, P Cardenas-Lizana, AV Kellner, Z Yuan, E Ahn, J Lyu, Z Li, K Salaita, R Ahmed, C Zhu 15/08/2023 Catch bond models may explain how force amplifies TCR signaling and antigen discrimination.
Nature communications
HK Choi, P Cong, C Ge, A Natarajan, B Liu, Y Zhang, K Li, MN Rushdi, W Chen, J Lou, M Krogsgaard, C Zhu 05/05/2023 The βI domain promotes active β1 integrin clustering into mature adhesion sites.
Life science alliance
G Mana, D Valdembri, JA Askari, Z Li, P Caswell, C Zhu, MJ Humphries, C Ballestrem, G Serini 01/02/2023 Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.
Nature communications
MN Rushdi, V Pan, K Li, HK Choi, S Travaglino, J Hong, F Griffitts, P Agnihotri, RA Mariuzza, Y Ke, C Zhu 17/11/2022 Signaling mechanisms of the platelet glycoprotein Ib-IX complex.
Platelets
Y Zhang, SM Ehrlich, C Zhu, X Du 18/08/2022 Immune-mediated alopecias and their mechanobiological aspects.
Cells & development
VE Watson, ML Faniel, NA Kamili, LD Krueger, C Zhu 01/06/2022 Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.
Advanced healthcare materials
CT Motz, V Kabat, T Saxena, RV Bellamkonda, C Zhu 01/10/2021 Distinct roles of ICOS and CD40L in human T-B cell adhesion and antibody production.
Cellular immunology
Z Liu, S Liu, Y Zhang, W Zeng, S Wang, P Ji, M Pan, C Zhu, Y Wang 01/10/2021 Journal of cell science
F Zhou, F Zhang, VI Zarnitsyna, L Doudy, Z Yuan, K Li, RP McEver, H Lu, C Zhu 15/09/2021 Cell reports
K Okubo, MD Brenner, X Cullere, G Saggu, ML Patchen, N Bose, S Mihori, Z Yuan, CA Lowell, C Zhu, TN Mayadas 18/05/2021 PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition.
Nature communications
K Li, Z Yuan, J Lyu, E Ahn, SJ Davis, R Ahmed, C Zhu 12/05/2021 Biomechanics and modeling in mechanobiology
Z Li, H Lee, SG Eskin, S Ono, C Zhu, LV McIntire 01/10/2020 Mechanotransduction in T Cell Development, Differentiation and Function.
Cells
M Rushdi, K Li, Z Yuan, S Travaglino, A Grakoui, C Zhu 05/02/2020 Dynamic bonds and their roles in mechanosensing.
Current opinion in chemical biology
C Zhu, Y Chen, LA Ju 01/12/2019 Author Correction: Mechanosensing through immunoreceptors.
Nature immunology
C Zhu, W Chen, J Lou, W Rittase, K Li 01/12/2019 Mechanosensing through immunoreceptors.
Nature immunology
C Zhu, W Chen, J Lou, W Rittase, K Li 01/10/2019 Domain-specific mechanical modulation of VWF-ADAMTS13 interaction.
Molecular biology of the cell
Z Li, J Lin, T Sulchek, MA Cruz, J Wu, JF Dong, C Zhu 22/07/2019 An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation.
Nature materials
Y Chen, LA Ju, F Zhou, J Liao, L Xue, QP Su, D Jin, Y Yuan, H Lu, SP Jackson, C Zhu 01/07/2019 Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor.
Science advances
R Wan, J Wu, M Ouyang, L Lei, J Wei, Q Peng, R Harrison, Y Wu, B Cheng, K Li, C Zhu, L Tang, Y Wang, S Lu 01/06/2019 Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition.
Molecular cell
P Wu, T Zhang, B Liu, P Fei, L Cui, R Qin, H Zhu, D Yao, RJ Martinez, W Hu, C An, Y Zhang, J Liu, J Shi, J Fan, W Yin, J Sun, C Zhou, X Zeng, C Xu, J Wang, BD Evavold, C Zhu, W Chen, J Lou 07/03/2019 Journal of cell science
H Lee, SG Eskin, S Ono, C Zhu, LV McIntire 04/02/2019 A TCR mechanotransduction signaling loop induces negative selection in the thymus.
Nature immunology
J Hong, C Ge, P Jothikumar, Z Yuan, B Liu, K Bai, K Li, W Rittase, M Shinzawa, Y Zhang, A Palin, P Love, X Yu, K Salaita, BD Evavold, A Singer, C Zhu 01/12/2018 Nature communications
G Saggu, K Okubo, Y Chen, R Vattepu, N Tsuboi, F Rosetti, X Cullere, N Washburn, S Tahir, AM Rosado, SM Holland, RM Anthony, M Sen, C Zhu, TN Mayadas 29/11/2018 Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.
Nature communications
XR Xu, Y Wang, R Adili, L Ju, CM Spring, JW Jin, H Yang, MAD Neves, P Chen, Y Yang, X Lei, Y Chen, RC Gallant, M Xu, H Zhang, J Song, P Ke, D Zhang, N Carrim, SY Yu, G Zhu, YM She, T Cyr, W Fu, G Liu, PW Connelly, ML Rand, K Adeli, J Freedman, JE Lee, P Tso, P Marchese, WS Davidson, SP Jackson, C Zhu, ZM Ruggeri, H Ni 06/09/2018 Blood
A Pang, Y Cui, Y Chen, N Cheng, MK Delaney, M Gu, A Stojanovic-Terpo, C Zhu, X Du 02/08/2018