Chris Yun, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-712-2865
Email Address

ccyun@emory.edu

Biography

Chang-Hyon Chris Yun, PhD, is a professor in the Department of Medicine at Emory University School of Medicine. Dr. Yun joined Emory University in 2002 from Johns Hopkins University.

Dr. Yun is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. He is also a member of Biochemistry, Cell and Developmental Biology (BCDB) program and Nutrition and Health Sciences (NHS) program at Emory University.

Education

Dr. Yun earned his PhD in Biophysics from University of Illinois at Urbana-Champaign, and went on to do postdoctoral training at Johns Hopkins University in electrolyte transport.

Titles & Roles

Professor, Department of Medicine, Division of Digestive Diseases

Emory University School of Medicine

Professional Memberships

Dr. Yun holds professional memberships with the American Physiological Society and American Gastroenterology Association.

Research

Dr. Yun's research is in mammalian intestine NHE3, a component of electroneutral NaCl absorption, which is a major constituent in basal Na+ and fluid absorption. This is a frequent target of inhibition in many diarrheal diseases. Another site of NHE3 is the kidney where 70% of HCO3- reabsorption can be attributed to Na+/H+ exchanger NHE3. NHE3 is regulated by hormones, growth factor, and external stimuli that target protein kinases. The first goal is to understand the mechanisms of NHE3 regulation by G protein-coupled receptors and protein kinases. The second goal is to delineate how the interaction of NHE3 with accessory proteins (NHERF1, NHERF2, and IRBIT) affects the signaling targeting NHE3. We are focusing on the cellular signaling elicited by glucocorticoids, angiotensin and lysophosphatidic acid (LPA).

Grants

View Grants

Grant Number	Title
5I01BX004459-04	Role of Na+/H+ exchanger in diabetic diarrhea
5R01DK116799-05	The function of lysophosphatidic acid receptor LPA5R in intestinal inflammation and epithelial damage

Title/Journal	Authors	Publication Date
LPA₅-Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation. American journal of physiology. Gastrointestinal and liver physiology	BB McConnell, Z Liang, C Xu, Y Han, CC Yun	09/04/2024
Regulation of the intestinal Na⁺/H⁺ exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563. American journal of physiology. Cell physiology	Y Han, P Bagchi, CC Yun	01/01/2024
Inhibition of protein kinase C-α and activation of ezrin by Lactobacillus acidophilus restore Na⁺/H⁺ exchange activity and fluid absorption in db/db mice. American journal of physiology. Endocrinology and metabolism	Y Han, S Srinivasan, CC Yun	01/09/2023
Compensatory Upregulation of LPA₂ and Activation of the PI3K-Akt Pathway Prevent LPA₅-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids. Cells	Z Liang, CC Yun	20/07/2022
Nedd4-2-dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli. Cellular and molecular gastroenterology and hepatology	KA Jenkin, Y Han, S Lin, P He, CC Yun	01/01/2022
Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA₅-Dependent Signaling. Cellular and molecular gastroenterology and hepatology	Z Liang, P He, Y Han, CC Yun	01/01/2022
Metformin Inhibits Na⁺/H⁺ Exchanger NHE3 Resulting in Intestinal Water Loss. Frontiers in physiology	Y Han, CC Yun	01/01/2022
Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5. Cellular and molecular gastroenterology and hepatology	M Wang, P He, Y Han, L Dong, CC Yun	01/01/2021
Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	Y Han, CC Yun	01/12/2020
Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer. Cancers	CC Yun	09/07/2019
Autotaxin determines colitis severity in mice and is secreted by B cells in the colon. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	S Lin, A Haque, R Raeman, L Guo, P He, TL Denning, B El-Rayes, WH Moolenaar, CC Yun	01/03/2019
Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	L Zhao, T Bartnikas, X Chu, J Klein, C Yun, S Srinivasan, P He	01/03/2019
Expression, Localization and Functional Activity of the Major Na⁺/H⁺ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	Y Yu, A Seidler, K Zhou, Z Yuan, S Yeruva, M Amiri, CC Yun, K Nikolovska, U Seidler	01/01/2019
Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na⁺/H⁺ exchanger 3 in SAMP1/Fc mice. American journal of physiology. Gastrointestinal and liver physiology	P He, A Haque, S Lin, F Cominelli, CC Yun	01/11/2018
Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na⁺/H⁺ exchanger 3 by lysophosphatidic acid in vivo. American journal of physiology. Gastrointestinal and liver physiology	KA Jenkin, P He, CC Yun	01/10/2018
Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis. The American journal of pathology	S Lin, Y Han, K Jenkin, SJ Lee, M Sasaki, JM Klapproth, P He, CC Yun	01/02/2018
Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience	SL Ritter-Makinson, M Paquet, JW Bogenpohl, RE Rodin, C Chris Yun, EJ Weinman, Y Smith, RA Hall	14/06/2017
Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library. European journal of medicinal chemistry	R Bai, Q Shi, Z Liang, Y Yoon, Y Han, A Feng, S Liu, Y Oum, CC Yun, H Shim	27/01/2017
The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II. American journal of physiology. Renal physiology	P He, L Zhao, YR No, S Karvar, CC Yun	01/08/2016
Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24. American journal of physiology. Gastrointestinal and liver physiology	M Yoshida, L Zhao, G Grigoryan, H Shim, P He, CC Yun	15/04/2016
Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia. PloS one	M Yoshida, P He, CC Yun	01/01/2016
Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. American journal of physiology. Cell physiology	YR No, P He, BK Yoo, CC Yun	01/07/2015
Diverse roles of LPA signaling in the intestinal epithelium. Experimental cell research	CC Yun, A Kumar	01/05/2015
HIF1α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. PloS one	YR No, SJ Lee, A Kumar, CC Yun	01/01/2015
Unique regulation of human Na+/H+ exchanger 3 (NHE3) by Nedd4-2 ligase that differs from non-primate NHE3s. The Journal of biological chemistry	YR No, P He, BK Yoo, CC Yun	27/06/2014
Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins. Physiological reports	HJ Lee, MH Kwon, S Lee, RA Hall, CC Yun, I Choi	01/05/2014
Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5. The Journal of biological chemistry	SJ Lee, YR No, DT Dang, LH Dang, VW Yang, H Shim, CC Yun	30/08/2013
Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Molecular and cellular biology	SJ Lee, G Leoni, PA Neumann, J Chun, A Nusrat, CC Yun	01/05/2013
Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs). The Journal of biological chemistry	Z Hu, J Hu, Z Zhang, WJ Shen, CC Yun, CH Berlot, FB Kraemer, S Azhar	19/04/2013
Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3. American journal of physiology. Gastrointestinal and liver physiology	BK Yoo, MK Yanda, YR No, CC Yun	15/07/2012
PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	S Lee, HS Yang, E Kim, EJ Ju, MH Kwon, RK Dudley, Y Smith, CC Yun, I Choi	01/01/2012
Development of a unique small molecule modulator of CXCR4. PloS one	Z Liang, W Zhan, A Zhu, Y Yoon, S Lin, M Sasaki, JM Klapproth, H Yang, HE Grossniklaus, J Xu, M Rojas, RJ Voll, MM Goodman, RF Arrendale, J Liu, CC Yun, JP Snyder, DC Liotta, H Shim	01/01/2012
Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells. American journal of physiology. Cell physiology	BK Yoo, P He, SJ Lee, CC Yun	01/11/2011
Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Molecular biology of the cell	P He, SJ Lee, S Lin, U Seidler, F Lang, G Fejes-Toth, A Naray-Fejes-Toth, CC Yun	01/10/2011
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells. Gastroenterology	SJ Lee, SL Ritter, H Zhang, H Shim, RA Hall, CC Yun	01/03/2011
GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2. Neuroscience letters	SL Ritter, MJ Asay, M Paquet, KJ Paavola, RE Reiff, CC Yun, RA Hall	03/01/2011
Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine. The Journal of physiology	M Chen, A Sultan, A Cinar, S Yeruva, B Riederer, AK Singh, J Li, J Bonhagen, G Chen, C Yun, M Donowitz, B Hogema, H de Jonge, U Seidler	15/12/2010
Colorectal cancer cells - Proliferation, survival and invasion by lysophosphatidic acid. The international journal of biochemistry & cell biology	SJ Lee, CC Yun	01/12/2010
The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. American journal of physiology. Gastrointestinal and liver physiology	S Lin, SJ Lee, H Shim, J Chun, CC Yun	01/11/2010
Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II. The Journal of biological chemistry	P He, J Klein, CC Yun	03/09/2010
Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology	S Lin, S Yeruva, P He, AK Singh, H Zhang, M Chen, G Lamprecht, HR de Jonge, M Tse, M Donowitz, BM Hogema, J Chun, U Seidler, CC Yun	01/02/2010
Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3. Journal of biomedicine & biotechnology	P He, CC Yun	01/01/2010
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology	S Lin, D Wang, S Iyer, AM Ghaleb, H Shim, VW Yang, J Chun, CC Yun	01/05/2009
Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons. The European journal of neuroscience	DS Cooper, HS Yang, P He, E Kim, I Rajbhandari, CC Yun, I Choi	01/02/2009
IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium. The Journal of biological chemistry	P He, H Zhang, CC Yun	28/11/2008