H. Trent Spencer, PhD
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Research Program
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Phone Number
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Email Address
Biography
H. Trent Spencer, PhD, is a professor in the Department of Pediatrics and director of the Gene and Cell Therapy Program in the Aflac Cancer and Blood Disorders Center. He is a Georgia Cancer Coalition Distinguished Scholar, and his areas of interest include gene therapy, stem cell biology, blood and marrow transplantation and immunotherapy. He is president and co-founder of Expression Therapeutics, a privately owned biotechnology company that is developing therapies for hemophilia A patients. His laboratory has a significant interest in translational research focused on cancer and bleeding disorders, and he has been involved in the submission of several projects leading to investigational new drug applications.
Dr. Spencer is a member of the Cancer Immunology Research Program at Winship Cancer Institute.
Education
Dr. Spencer received his PhD from Creighton University School of Medicine in Omaha, Nebraska. He completed his postdoctoral research at St. Jude Children’s Research Hospital in Memphis, Tennessee.
Titles & Roles
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Professor, Department of PediatricsEmory University School of Medicine
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Director, Gene and Cell TherapyAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta
Professional Memberships
Dr. Spencer is a member of the American Society of Cell and Gene Therapy and a member of several committees within the society.
Research
The development of gene therapy treatments for childhood cancer and inherited diseases is the major focus of Dr. Spencer's laboratory. His group has pioneered an approach to treat cancer using novel immunotherapies, termed Drug Resistance Immunotherapy (DRI). His lab is testing if immunocompetent cells can be genetically engineered to withstand the toxic effects of chemotherapy, and if so, whether the genetic modification can allow for the combined use of chemotherapy and cell-based immunotherapy, which may result in increased survival with reduced chemotherapy administration compared to individual chemotherapy or immunotherapy treatments. His group has also developed novel chimeric antigen receptors that can be used to direct immunocompetent cells to tumors, which results in anti-tumor immunity. In addition, gene therapy treatments for the bleeding disorder, hemophilia, have been developed and are advancing to clinical trials, with a hope of curing the disease.
Grants
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Grant Number Title 1K08CA248962-01 Gamma delta T-cell immunotherapy for T-cell acute lymphoblastic leukemia 1K08HL141635-01A1 Targeted non-genotoxic hematopoietic stem cell transplant conditioning approach 2T32HL069769-16 Training Grant in Transfusion Medicine 5K08CA248962-02 Gamma delta T-cell immunotherapy for T-cell acute lymphoblastic leukemia Title/Journal Authors Publication Date Journal of thrombosis and haemostasis : JTH
CW Coyle, KA Knight, HC Brown, SN George, G Denning, GM Branella, KC Childers, PC Spiegel, HT Spencer, CB Doering 01/03/2024 Directing the migration of serum-free, ex vivo-expanded Vγ9Vδ2 T cells.
Frontiers in immunology
KK Parwani, GM Branella, RE Burnham, AJ Burnham, AYS Bustamante, EM Foppiani, KA Knight, BG Petrich, EM Horwitz, CB Doering, HT Spencer 01/01/2024 Nature communications
M Rodriguez, B Trevisan, RM Ramamurthy, SK George, J Diaz, J Alexander, D Meares, DJ Schwahn, DR Quilici, J Figueroa, M Gautreaux, A Farland, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada 14/07/2023 Cell reports. Medicine
JY Lee, HC Jonus, A Sadanand, GM Branella, V Maximov, S Suttapitugsakul, MJ Schniederjan, J Shim, A Ho, KK Parwani, A Fedanov, AA Pilgrim, JA Silva, RW Schnepp, CB Doering, R Wu, HT Spencer, KC Goldsmith 20/06/2023 Molecular therapy oncolytics
SA Becker, BG Petrich, B Yu, KA Knight, HC Brown, SS Raikar, CB Doering, HT Spencer 15/06/2023 Frontiers in immunology
GM Branella, JY Lee, J Okalova, KK Parwani, JS Alexander, RF Arthuzo, A Fedanov, B Yu, D McCarty, HC Brown, S Chandrakasan, BG Petrich, CB Doering, HT Spencer 01/01/2023 Blood advances
KC Childers, SC Peters, P Lollar, HT Spencer, CB Doering, PC Spiegel 14/06/2022 Gene therapy
JT Zoine, C Prince, JY Story, GM Branella, AM Lytle, A Fedanov, JS Alexander, CC Porter, CB Doering, HT Spencer, S Chandrakasan 01/05/2022 Blood advances
TS Lundgren, G Denning, SR Stowell, HT Spencer, CB Doering 26/04/2022 Blood
CR Funk, S Wang, KZ Chen, A Waller, A Sharma, CL Edgar, VA Gupta, S Chandrakasan, JT Zoine, A Fedanov, SS Raikar, JL Koff, CR Flowers, S Coma, JA Pachter, S Ravindranathan, HT Spencer, M Shanmugam, EK Waller 27/01/2022 Frontiers in immunology
RM Ramamurthy, M Rodriguez, HC Ainsworth, J Shields, D Meares, C Bishop, A Farland, CD Langefeld, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada 01/01/2022 Oncoimmunology
HC Jonus, RE Burnham, A Ho, AA Pilgrim, J Shim, CB Doering, HT Spencer, KC Goldsmith 01/01/2022 Cells
GM Branella, HT Spencer 22/12/2021 Molecular therapy. Methods & clinical development
SRP Kumar, J Xie, S Hu, J Ko, Q Huang, HC Brown, A Srivastava, DM Markusic, CB Doering, HT Spencer, A Srivastava, G Gao, RW Herzog 10/12/2021 Scientific reports
LS Lamb, L Pereboeva, S Youngblood, GY Gillespie, LB Nabors, JM Markert, A Dasgupta, C Langford, HT Spencer 26/10/2021 Blood advances
KA Knight, CW Coyle, CE Radford, ET Parker, A Fedanov, JM Shields, F Szlam, A Purchel, M Chen, G Denning, RM Sniecinski, P Lollar, HT Spencer, EA Gaucher, CB Doering 14/09/2021 Molecular therapy. Methods & clinical development
AL Russell, C Prince, TS Lundgren, KA Knight, G Denning, JS Alexander, JT Zoine, HT Spencer, S Chandrakasan, CB Doering 11/06/2021 Blood
JS Gish, L Jarvis, KC Childers, SC Peters, CS Garrels, IW Smith, HT Spencer, CB Doering, P Lollar, PC Spiegel 27/05/2021 Cryobiology
RE Burnham, D Tope, G Branella, E Williams, CB Doering, HT Spencer 01/04/2021 Molecular coevolution of coagulation factor VIII and von Willebrand factor.
Blood advances
PM Zakas, CW Coyle, A Brehm, M Bayer, B Solecka-Witulska, CE Radford, C Brown, K Nesbitt, C Dwyer, C Kannicht, HT Spencer, EA Gaucher, CB Doering, D Lillicrap 09/02/2021 Current stem cell reports
A Dasgupta, K Herzegh, HT Spencer, C Doering, E Day, WP Swaney 01/01/2021 Cytotherapy
JY Story, JT Zoine, RE Burnham, JAG Hamilton, HT Spencer, CB Doering, SS Raikar 01/01/2021 Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A.
Frontiers in bioengineering and biotechnology
B Trevisan, A Morsi, J Aleman, M Rodriguez, J Shields, D Meares, AM Farland, CB Doering, HT Spencer, A Atala, A Skardal, CD Porada, G Almeida-Porada 01/01/2021 Frontiers in cell and developmental biology
C Stem, C Rodman, RM Ramamurthy, S George, D Meares, A Farland, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada 01/01/2021 Frontiers in immunology
EK Ronayne, SC Peters, JS Gish, C Wilson, HT Spencer, CB Doering, P Lollar, PC Spiegel, KC Childers 01/01/2021 Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B.
Human gene therapy
HC Brown, CB Doering, RW Herzog, C Ling, DM Markusic, HT Spencer, A Srivastava, A Srivastava 01/10/2020 Molecular therapy oncolytics
LC Fleischer, SA Becker, RE Ryan, A Fedanov, CB Doering, HT Spencer 25/09/2020 Defining the Optimal FVIII Transgene for Placental Cell-Based Gene Therapy to Treat Hemophilia A.
Molecular therapy. Methods & clinical development
N El-Akabawy, M Rodriguez, R Ramamurthy, A Rabah, B Trevisan, A Morsi, S George, J Shields, D Meares, A Farland, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada 12/06/2020 Human gene therapy
SE Takushi, NY Paik, A Fedanov, C Prince, CB Doering, HT Spencer, S Chandrakasan 01/06/2020 The Immune Response to the fVIII Gene Therapy in Preclinical Models.
Frontiers in immunology
SR Patel, TS Lundgren, HT Spencer, CB Doering 01/01/2020 Frontiers in medicine
RE Burnham, JT Zoine, JY Story, SN Garimalla, G Gibson, A Rae, E Williams, L Bixby, D Archer, CB Doering, HT Spencer 01/01/2020 Journal of thrombosis and haemostasis : JTH
IW Smith, AE d'Aquino, CW Coyle, A Fedanov, ET Parker, G Denning, HT Spencer, P Lollar, CB Doering, PC Spiegel 01/01/2020 Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions.
Journal of hematology & oncology
LC Fleischer, HT Spencer, SS Raikar 29/12/2019 Oncoimmunology
JT Zoine, KA Knight, LC Fleischer, KS Sutton, KC Goldsmith, CB Doering, HT Spencer 01/01/2019 Human gene therapy
CB Doering, G Denning, JE Shields, EJ Fine, ET Parker, A Srivastava, P Lollar, HT Spencer 01/10/2018 Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A.
Molecular therapy. Methods & clinical development
HC Brown, PM Zakas, SN George, ET Parker, HT Spencer, CB Doering 15/06/2018 Hurdles Associated with the Translational Use of Genetically Modified Cells.
Current stem cell reports
SS Raikar, HT Spencer 01/03/2018 Blood advances
CT Petersen, M Hassan, AB Morris, J Jeffery, K Lee, N Jagirdar, AD Staton, SS Raikar, HT Spencer, T Sulchek, CR Flowers, EK Waller 13/02/2018 Oncoimmunology
SS Raikar, LC Fleischer, R Moot, A Fedanov, NY Paik, KA Knight, CB Doering, HT Spencer 01/01/2018 Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency.
Molecular therapy : the journal of the American Society of Gene Therapy
R Tran, DR Myers, G Denning, JE Shields, AM Lytle, H Alrowais, Y Qiu, Y Sakurai, WC Li, O Brand, JM Le Doux, HT Spencer, CB Doering, WA Lam 04/10/2017 Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction.
Nature biotechnology
PM Zakas, HC Brown, K Knight, SL Meeks, HT Spencer, EA Gaucher, CB Doering 01/01/2017 Bioengineering and serum free expansion of blood-derived γδ T cells.
Cytotherapy
KS Sutton, A Dasgupta, D McCarty, CB Doering, HT Spencer 01/07/2016 Molecular therapy oncolytics
R Moot, SS Raikar, L Fleischer, M Querrey, DE Tylawsky, H Nakahara, CB Doering, HT Spencer 01/01/2016 Molecular therapy. Methods & clinical development
AM Lytle, HC Brown, NY Paik, KA Knight, JF Wright, HT Spencer, CB Doering 01/01/2016 Replacing bad (F)actors: hemophilia.
Hematology. American Society of Hematology. Education Program
CB Doering, HT Spencer 05/12/2014 Simplified prototyping of perfusable polystyrene microfluidics.
Biomicrofluidics
R Tran, B Ahn, DR Myers, Y Qiu, Y Sakurai, R Moot, E Mihevc, H Trent Spencer, C Doering, W A Lam 01/07/2014 Molecular therapy. Methods & clinical development
HC Brown, JF Wright, S Zhou, AM Lytle, JE Shields, HT Spencer, CB Doering 01/01/2014 Human gene therapy methods
L Baranyi, CB Doering, G Denning, RE Gautney, KT Harris, HT Spencer, A Roy, H Zayed, B Dropulic 01/08/2013 PloS one
LS Lamb, J Bowersock, A Dasgupta, GY Gillespie, Y Su, A Johnson, HT Spencer 01/01/2013 Human gene therapy
A Dasgupta, JE Shields, HT Spencer 01/07/2012 Development and characterization of recombinant ovine coagulation factor VIII.
PloS one
PM Zakas, B Gangadharan, G Almeida-Porada, CD Porada, HT Spencer, CB Doering 01/01/2012 Experimental hematology
CD Porada, C Sanada, CJ Kuo, E Colletti, W Mandeville, J Hasenau, ED Zanjani, R Moot, C Doering, HT Spencer, G Almeida-Porada 01/12/2011 Engineered Hematopoietic Stem Cells as Therapeutics for Hemophilia A.
Journal of genetic syndromes & gene therapy
PM Zakas, HT Spencer, CB Doering 16/11/2011 Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.
Molecular therapy : the journal of the American Society of Gene Therapy
HT Spencer, G Denning, RE Gautney, B Dropulic, AJ Roy, L Baranyi, B Gangadharan, ET Parker, P Lollar, CB Doering 01/02/2011 Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells.
Advanced drug delivery reviews
CB Doering, D Archer, HT Spencer 30/09/2010 The journal of gene medicine
LM Ide, NN Iwakoshi, B Gangadharan, S Jobe, R Moot, D McCarty, CB Doering, HT Spencer 01/04/2010 BMC biotechnology
JL Taylor, P Rohatgi, HT Spencer, DF Doyle, B Azizi 18/02/2010 Biochemical and biophysical research communications
A Dasgupta, D McCarty, HT Spencer 01/01/2010 Advancements in gene transfer-based therapy for hemophilia A.
Expert review of hematology
CB Doering, HT Spencer 01/12/2009 Molecular therapy : the journal of the American Society of Gene Therapy
CB Doering, G Denning, K Dooriss, B Gangadharan, JM Johnston, KW Kerstann, DA McCarty, HT Spencer 01/07/2009 Human gene therapy
KL Dooriss, G Denning, B Gangadharan, EH Javazon, DA McCarty, HT Spencer, CB Doering 01/05/2009 Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells.
Methods in molecular biology (Clifton, N.J.)
LM Ide, E Javazon, HT Spencer 01/01/2008