Dmitry Shayakhmetov,, PhD
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Research Program
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Email Address
Biography
Dmitry M. Shayakhmetov, PhD, is a professor in the Department of Medicine at Emory University School of Medicine. Prior to joining the Lowance Center for Human Immunology at Emory University in April of 2014, Dr. Shayakhmetov was associate professor in the Department of Medicine at the University of Washington in Seattle.
Dr. Shayakhmetov is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.
Education
Dr. Shayakhmetov obtained his BS degree in biochemistry and PhD degree in molecular biology and virology under the supervision of one of the leading virologists in Russia, Professor Thomas Tikchonenko. He obtained his postdoctoral training in virology and immunology in the laboratory of Dr. Andre Lieber, in the Department of Medicine at the University of Washington in Seattle.
Titles & Roles
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Professor, Department of MedicineEmory University School of Medicine
Professional Memberships
Dr. Shayakhmetov is a member of several professional societies, including the American Association of Immunologists, American Society for Microbiology, American Association for the Advancement of Science and American Society of Gene and Cell Therapy. He serves as an editorial board member of Molecular Therapy, Cancer Gene Therapy, and Genes and Immunity journals, as well as participating as an ad hoc reviewer at the NIH study sections (VIR-A, GDD, and III) and many international grant review panels. Since 2012, Dr. Shayakhmetov has served as a regular member of the NIH Innate Immunity and Inflammation study section.
Research
The main focus of Dr. Shayakhmetov's research program has been on improving our understanding of the role of innate immunity in initiating and exacerbating inflammation in response to viral (adenovirus) and bacterial pathogens, and tissue damage. The interplay between pro-inflammatory IL-1- and TNF-dependent signaling pathways in the context of infection and sterile tissue damage is the current focus of his research. Specifically, he is interested to understand the role of non-apoptotic pro-inflammatory cell death in triggering devastating local and systemic inflammation, associated with severe acute bacterial infections, sepsis, and several autoimmune and autoinflammatory disorders.
Over the years, Dr. Shayakhmetov's research program has been supported by the grants from the National Institutes of Health and private foundations, including Cystic Fibrosis Foundation and the Bill and Melinda Gates Foundation.
Grants
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Grant Number Title 2R01AI107960-06 Mechanisms of adenovirus neutralization 5R01AI107960-07 Mechanisms of adenovirus neutralization 5R01AI107960-08 Mechanisms of adenovirus neutralization 5R01AI107960-09 Mechanisms of adenovirus neutralization Title/Journal Authors Publication Date TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.
Molecular therapy : the journal of the American Society of Gene Therapy
SRP Kumar, M Biswas, D Cao, S Arisa, M Muñoz-Melero, AK Lam, AR Piñeros, R Kapur, T Kaisho, RJ Kaufman, W Xiao, DM Shayakhmetov, C Terhorst, YP de Jong, RW Herzog 07/02/2024 Molecular therapy : the journal of the American Society of Gene Therapy
J Yao, S Atasheva, N Wagner, NC Di Paolo, PL Stewart, DM Shayakhmetov 03/01/2024 The Journal of clinical investigation
Z Chen, B Giotti, M Kaluzova, MP Vallcorba, K Rawat, G Price, CJ Herting, G Pinero, S Cristea, JL Ross, J Ackley, V Maximov, F Szulzewsky, W Thomason, M Marquez-Ropero, A Angione, N Nichols, NM Tsankova, F Michor, DM Shayakhmetov, DH Gutmann, AM Tsankov, D Hambardzumyan 15/11/2023 Viruses
N Wagner, DM Shayakhmetov, PL Stewart 09/06/2023 p38MAPK guards the integrity of endosomal compartments through regulating necrotic death.
Scientific reports
J Yao, S Atasheva, R Toy, EL Blanchard, PJ Santangelo, K Roy, ES Mocarski, DM Shayakhmetov 29/09/2022 Adenovirus-based vaccines-a platform for pandemic preparedness against emerging viral pathogens.
Molecular therapy : the journal of the American Society of Gene Therapy
L Coughlan, EJ Kremer, DM Shayakhmetov 04/05/2022 Cytokine Responses to Adenovirus and Adenovirus Vectors.
Viruses
S Atasheva, DM Shayakhmetov 24/04/2022 Apoptosis : an international journal on programmed cell death
VL Kolachala, C Lopez, M Shen, D Shayakhmetov, NA Gupta 01/06/2021 Oncolytic Viruses for Systemic Administration: Engineering a Whole Different Animal.
Molecular therapy : the journal of the American Society of Gene Therapy
S Atasheva, DM Shayakhmetov 03/03/2021 PLoS pathogens
W Lee, B Kingstad-Bakke, B Paulson, A Larsen, K Overmyer, CB Marinaik, K Dulli, R Toy, G Vogel, KP Mueller, K Tweed, AJ Walsh, J Russell, K Saha, L Reyes, MC Skala, JD Sauer, DM Shayakhmetov, J Coon, K Roy, M Suresh 01/01/2021 Science advances
P Pradhan, R Toy, N Jhita, A Atalis, B Pandey, A Beach, EL Blanchard, SG Moore, DA Gaul, PJ Santangelo, DM Shayakhmetov, K Roy 01/01/2021 Systemic cancer therapy with engineered adenovirus that evades innate immunity.
Science translational medicine
S Atasheva, CC Emerson, J Yao, C Young, PL Stewart, DM Shayakhmetov 25/11/2020 Biomaterials
R Toy, P Pradhan, V Ramesh, NC Di Paolo, B Lash, J Liu, EL Blanchard, CJ Pinelli, PJ Santangelo, DM Shayakhmetov, K Roy 01/12/2019 Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema.
Brain : a journal of neurology
CJ Herting, Z Chen, V Maximov, A Duffy, F Szulzewsky, DM Shayakhmetov, D Hambardzumyan 01/12/2019 Innate immunity to adenovirus: lessons from mice.
FEBS letters
S Atasheva, J Yao, DM Shayakhmetov 01/12/2019 Hepatology communications
VL Kolachala, SK Palle, M Shen, A Shenoi, DM Shayakhmetov, NA Gupta 01/07/2019 Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Immunity
P Mandal, Y Feng, JD Lyons, SB Berger, S Otani, A DeLaney, GK Tharp, K Maner-Smith, EM Burd, M Schaeffer, S Hoffman, C Capriotti, L Roback, CB Young, Z Liang, EA Ortlund, NC DiPaolo, S Bosinger, J Bertin, PJ Gough, IE Brodsky, CM Coopersmith, DM Shayakhmetov, ES Mocarski 17/07/2018 Microbes and infection
NN McNair, C Bedi, DM Shayakhmetov, MJ Arrowood, JR Mead 01/01/2018 Hepatology (Baltimore, Md.)
VL Kolachala, S Palle, M Shen, A Feng, D Shayakhmetov, NA Gupta 01/10/2017 Adenovirus sensing by the immune system.
Current opinion in virology
S Atasheva, DM Shayakhmetov 01/12/2016 Interleukin 1α and the inflammatory process.
Nature immunology
NC Di Paolo, DM Shayakhmetov 19/07/2016 Awards
In 2008, Dr. Shayakhmetov was awarded the Outstanding New Investigator Award by the American Society of Gene and Cell Therapy for his contribution to deciphering molecular mechanisms triggering severe inflammation to adenovirus vectors in clinically-relevant settings.