Khalid Salaita, PhD
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Research Program
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Phone Number
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Email Address
Biography
Khalid Salaita, PhD, is the Samuel Chandler Dobbs Professor of Chemistry, associate professor and director of graduate studies in the Department of Chemistry at Emory University. He is also program faculty in the Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology.
Dr. Salaita is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.
Education
Dr. Salaita earned his PhD in Chemistry from Northwestern University in 2006. After obtaining his PhD, Dr. Salaita completed a postdoctoral fellowship in the Department of Chemistry at the University of California, Berkeley.
Titles & Roles
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Associate Professor and Director for Graduate Studies, Department of ChemistryEmory University
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Samuel Candler Dobbs Professor of ChemistryEmory University
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Program Faculty, Department of Biomedical EngineeringEmory University and Georgia Institute of Technology
Research
Dr. Salaita's lab is interested in studying the role of mechanical forces in cell biology and tumor development. To address this goal, they develop new technologies to image mechanical forces generated by cells using molecules that fluoresce upon experiencing mechanical tension. They also develop nanoparticle actuators that can apply mechanical forces to cells, allowing them to understand how forces influence biology and disease progression.
Grants
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Title/Journal Authors Publication Date "Turbo-Charged" DNA Motors with Optimized Sequence Enable Single-Molecule Nucleic Acid Sensing.
Angewandte Chemie (International ed. in English)
L Zhang, S Piranej, A Namazi, S Narum, K Salaita 22/03/2024 Journal of the American Chemical Society
J Rogers, R Ma, A Foote, Y Hu, K Salaita 20/03/2024 Measuring integrin force loading rates using a two-step DNA tension sensor.
bioRxiv : the preprint server for biology
JD Combs, AK Foote, H Ogasawara, A Velusamy, SA Rashid, JN Mancuso, K Salaita 15/03/2024 Molecular Compressive Force Sensor for Mapping Forces at the Cell-Substrate Interface.
Journal of the American Chemical Society
S Al Abdullatif, S Narum, Y Hu, J Rogers, R Fitzgerald, K Salaita 13/03/2024 An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids.
ACS nano
S Narum, B Deal, H Ogasawara, JN Mancuso, J Zhang, K Salaita 27/02/2024 Science signaling
J Eggert, WM Zinzow-Kramer, Y Hu, EM Kolawole, YL Tsai, A Weiss, BD Evavold, K Salaita, CD Scharer, BB Au-Yeung 06/02/2024 bioRxiv : the preprint server for biology
AV Kellner, R Hunter, P Do, J Eggert, M Jaffe, DK Geitgey, M Lee, JAG Hamilton, AJ Ross, RS Ank, RL Bender, R Ma, CC Porter, EC Dreaden, BB Au-Yeung, KA Haynes, CJ Henry, K Salaita 02/02/2024 Heteromultivalency enables enhanced detection of nucleic acid mutations.
Nature chemistry
BR Deal, R Ma, S Narum, H Ogasawara, Y Duan, JT Kindt, K Salaita 01/02/2024 Scientific reports
P Forghani, A Rashid, LC Armand, D Wolfson, R Liu, HC Cho, JT Maxwell, H Jo, K Salaita, C Xu 26/01/2024 DNA mechanocapsules for programmable piconewton responsive drug delivery.
Nature communications
A Velusamy, R Sharma, SA Rashid, H Ogasawara, K Salaita 24/01/2024 Nature communications
MS Wang, Y Hu, EE Sanchez, X Xie, NH Roy, M de Jesus, BY Winer, EA Zale, W Jin, C Sachar, JH Lee, Y Hong, M Kim, LC Kam, K Salaita, M Huse 18/12/2023 Force-Triggered Self-Destructive Hydrogels.
Advanced materials (Deerfield Beach, Fla.)
T Rajasooriya, H Ogasawara, Y Dong, JN Mancuso, K Salaita 01/12/2023 Polarized focal adhesion kinase activity within a focal adhesion during cell migration.
Nature chemical biology
X Li, JD Combs, K Salaita, X Shu 01/12/2023 Nanodiscoidal Nucleic Acids for Gene Regulation.
ACS chemical biology
R Sharma, S Narum, S Liu, Y Dong, KI Baek, H Jo, K Salaita 17/11/2023 Nature biomedical engineering
Y Duan, F Szlam, Y Hu, W Chen, R Li, Y Ke, R Sniecinski, K Salaita 01/11/2023 Molecular mechanocytometry using tension-activated cell tagging.
Nature methods
R Ma, SA Rashid, A Velusamy, BR Deal, W Chen, B Petrich, R Li, K Salaita 01/11/2023 ACS biomaterials science & engineering
AN Ramey-Ward, Y Dong, J Yang, H Ogasawara, EC Bremer-Sai, O Brazhkina, C Franck, M Davis, K Salaita 11/09/2023 Mechanical force regulates ligand binding and function of PD-1.
bioRxiv : the preprint server for biology
K Li, P Cardenas-Lizana, AV Kellner, Z Yuan, E Ahn, J Lyu, Z Li, K Salaita, R Ahmed, C Zhu 15/08/2023 bioRxiv : the preprint server for biology
J Rogers, R Ma, Y Hu, K Salaita 08/08/2023 DNA Nanotechnology for Investigating Mechanical Signaling in the Immune System.
Angewandte Chemie (International ed. in English)
Y Hu, Y Duan, K Salaita 24/07/2023 ACS applied materials & interfaces
SA Rashid, Y Dong, H Ogasawara, M Vierengel, ME Essien, K Salaita 19/07/2023 DNA Origami Tension Sensors (DOTS) to study T cell receptor mechanics at membrane junctions.
bioRxiv : the preprint server for biology
Y Hu, Y Duan, A Velusamy, S Narum, J Rogers, K Salaita 12/07/2023 Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor.
bioRxiv : the preprint server for biology
S Piranej, L Zhang, A Bazrafshan, M Marin, GB Melikyan, K Salaita 28/02/2023 RTK-integrin interactions universally modulate αVβ3 integrin-mediated cell adhesion.
Biophysical journal
TC Rao, MD Patel, RR Beggs, R Ma, K Salaita, AL Mattheyses 10/02/2023 bioRxiv : the preprint server for biology
J Eggert, WM Zinzow-Kramer, Y Hu, YL Tsai, A Weiss, K Salaita, CD Scharer, BB Au-Yeung 28/01/2023 Adhesive Dynamics Simulations of Highly Polyvalent DNA Motors.
The journal of physical chemistry. B
AT Blanchard, S Piranej, V Pan, K Salaita 06/10/2022 Nature communications
MS Wang, Y Hu, EE Sanchez, X Xie, NH Roy, M de Jesus, BY Winer, EA Zale, W Jin, C Sachar, JH Lee, Y Hong, M Kim, LC Kam, K Salaita, M Huse 09/06/2022 Chemical-to-mechanical molecular computation using DNA-based motors with onboard logic.
Nature nanotechnology
S Piranej, A Bazrafshan, K Salaita 01/05/2022 ACS nano
SA Rashid, AT Blanchard, JD Combs, N Fernandez, Y Dong, HC Cho, K Salaita 26/04/2022 Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis.
Nature communications
TJ Nawara, YD Williams, TC Rao, Y Hu, E Sztul, K Salaita, AL Mattheyses 01/04/2022 The Journal of biological chemistry
TC Rao, RR Beggs, KE Ankenbauer, J Hwang, VP Ma, K Salaita, SL Bellis, AL Mattheyses 01/04/2022 The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation.
Science advances
VP Ma, Y Hu, AV Kellner, JM Brockman, A Velusamy, AT Blanchard, BD Evavold, R Alon, K Salaita 25/02/2022 Gene Regulation Using Nanodiscs Modified with HIF-1-α Antisense Oligonucleotides.
Bioconjugate chemistry
R Sharma, Y Dong, Y Hu, VP Ma, K Salaita 16/02/2022 Journal of the American Heart Association
P Forghani, A Rashid, F Sun, R Liu, D Li, MR Lee, H Hwang, JT Maxwell, A Mandawat, R Wu, K Salaita, C Xu 21/12/2021 Nano letters
Y Dong, JD Combs, C Cao, ER Weeks, A Bazrafshan, SA Rashid, K Salaita 08/12/2021 Smart Nucleic Acids as Future Therapeutics.
Trends in biotechnology
J Zhang, K Salaita 01/12/2021 Massively Parallelized Molecular Force Manipulation with On-Demand Thermal and Optical Control.
Journal of the American Chemical Society
H Su, JM Brockman, Y Duan, N Sen, H Chhabra, A Bazrafshan, AT Blanchard, T Meyer, B Andrews, JPK Doye, Y Ke, RB Dyer, K Salaita 24/11/2021 Conditional Antisense Oligonucleotides Triggered by miRNA.
ACS chemical biology
J Zhang, R Sharma, K Ryu, P Shen, K Salaita, H Jo 19/11/2021 Programmable Mechanically Active Hydrogel-Based Materials.
Advanced materials (Deerfield Beach, Fla.)
Y Dong, AN Ramey-Ward, K Salaita 01/11/2021 Nature communications
A Blanchard, JD Combs, JM Brockman, AV Kellner, R Glazier, H Su, RL Bender, AS Bazrafshan, W Chen, ME Quach, R Li, AL Mattheyses, K Salaita 16/09/2021 Mechanically Triggered Hybridization Chain Reaction.
Angewandte Chemie (International ed. in English)
Y Duan, R Glazier, A Bazrafshan, Y Hu, SA Rashid, BG Petrich, Y Ke, K Salaita 01/09/2021 Angewandte Chemie (International ed. in English)
Y Hu, VP Ma, R Ma, W Chen, Y Duan, R Glazier, BG Petrich, R Li, K Salaita 09/08/2021 Nature communications
A Blanchard, JD Combs, JM Brockman, AV Kellner, R Glazier, H Su, RL Bender, AS Bazrafshan, W Chen, ME Quach, R Li, AL Mattheyses, K Salaita 03/08/2021 ACS nano
A Bazrafshan, ME Kyriazi, BA Holt, W Deng, S Piranej, H Su, Y Hu, AH El-Sagheer, T Brown, GA Kwong, AG Kanaras, K Salaita 25/05/2021 DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells.
Journal of visualized experiments : JoVE
R Ma, AV Kellner, Y Hu, BR Deal, AT Blanchard, K Salaita 20/03/2021 Multivalent molecular tension probes as anisotropic mechanosensors: concept and simulation.
Physical biology
AT Blanchard, K Salaita 15/03/2021 ACS applied materials & interfaces
R Glazier, P Shinde, H Ogasawara, K Salaita 20/01/2021 Frontiers in cell and developmental biology
LA Pérez, A Rashid, JD Combs, P Schneider, A Rodríguez, K Salaita, L Leyton 01/01/2021 Journal of the American Chemical Society
AD Merg, G Touponse, EV Genderen, TB Blum, X Zuo, A Bazrafshan, HMH Siaw, A McCanna, R Brian Dyer, K Salaita, JP Abrahams, VP Conticello 25/11/2020 Live-cell super-resolved PAINT imaging of piconewton cellular traction forces.
Nature methods
JM Brockman, H Su, AT Blanchard, Y Duan, T Meyer, ME Quach, R Glazier, A Bazrafshan, RL Bender, AV Kellner, H Ogasawara, R Ma, F Schueder, BG Petrich, R Jungmann, R Li, AL Mattheyses, Y Ke, K Salaita 01/10/2020 ACS nano
YC Chen, C Sood, M Marin, J Aaron, E Gratton, K Salaita, GB Melikyan 22/09/2020 Conditional Deoxyribozyme-Nanoparticle Conjugates for miRNA-Triggered Gene Regulation.
ACS applied materials & interfaces
J Zhang, R Ma, A Blanchard, J Petree, H Jo, K Salaita 26/08/2020 ACS applied materials & interfaces
AN Ramey-Ward, H Su, K Salaita 12/08/2020 Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency.
Biomacromolecules
LA Perdue, P Do, C David, A Chyong, AV Kellner, A Ruggieri, HR Kim, K Salaita, GB Lesinski, CC Porter, EC Dreaden 13/07/2020 Journal of cell science
TC Rao, VP Ma, A Blanchard, TM Urner, S Grandhi, K Salaita, AL Mattheyses 10/07/2020 Tunable DNA Origami Motors Translocate Ballistically Over μm Distances at nm/s Speeds.
Angewandte Chemie (International ed. in English)
A Bazrafshan, TA Meyer, H Su, JM Brockman, AT Blanchard, S Piranej, Y Duan, Y Ke, K Salaita 08/06/2020 Journal of the American Chemical Society
BR Deal, R Ma, VP Ma, H Su, JT Kindt, K Salaita 27/05/2020 Forces during cellular uptake of viruses and nanoparticles at the ventral side.
Nature communications
T Wiegand, M Fratini, F Frey, K Yserentant, Y Liu, E Weber, K Galior, J Ohmes, F Braun, DP Herten, S Boulant, US Schwarz, K Salaita, EA Cavalcanti-Adam, JP Spatz 02/01/2020 Journal of the American Chemical Society
AD Merg, E van Genderen, A Bazrafshan, H Su, X Zuo, G Touponse, TB Blum, K Salaita, JP Abrahams, VP Conticello 26/12/2019 Nature communications
R Glazier, JM Brockman, E Bartle, AL Mattheyses, O Destaing, K Salaita 18/10/2019 Highly Polyvalent DNA Motors Generate 100+ pN of Force via Autochemophoresis.
Nano letters
AT Blanchard, AS Bazrafshan, J Yi, JT Eisman, KM Yehl, T Bian, A Mugler, K Salaita 09/10/2019 Chameleon-Inspired Strain-Accommodating Smart Skin.
ACS nano
Y Dong, A Bazrafshan, A Pokutta, F Sulejmani, W Sun, JD Combs, KC Clarke, K Salaita 24/09/2019 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks.
Angewandte Chemie (International ed. in English)
AD Merg, G Touponse, E van Genderen, X Zuo, A Bazrafshan, T Blum, S Hughes, K Salaita, JP Abrahams, VP Conticello 16/09/2019 Emerging uses of DNA mechanical devices.
Science (New York, N.Y.)
AT Blanchard, K Salaita 13/09/2019 DNA probes that store mechanical information reveal transient piconewton forces applied by T cells.
Proceedings of the National Academy of Sciences of the United States of America
R Ma, AV Kellner, VP Ma, H Su, BR Deal, JM Brockman, K Salaita 20/08/2019 Cell death & disease
Z Yuan, JR Petree, FE Lee, X Fan, K Salaita, DM Guidot, RT Sadikot 02/08/2019 DNA Nanotechnology as an Emerging Tool to Study Mechanotransduction in Living Systems.
Small (Weinheim an der Bergstrasse, Germany)
VP Ma, K Salaita 01/06/2019 Frontiers in physics
JM Brockman, K Salaita 01/02/2019 Localized Nanoscale Heating Leads to Ultrafast Hydrogel Volume-Phase Transition.
ACS nano
J Zhao, H Su, GE Vansuch, Z Liu, K Salaita, RB Dyer 22/01/2019 A TCR mechanotransduction signaling loop induces negative selection in the thymus.
Nature immunology
J Hong, C Ge, P Jothikumar, Z Yuan, B Liu, K Bai, K Li, W Rittase, M Shinzawa, Y Zhang, A Palin, P Love, X Yu, K Salaita, BD Evavold, A Singer, C Zhu 01/12/2018 Location, Location, Location: EphB4:Ephrin-B2 Signaling Depends on Its Spatial Arrangement.
Biophysical journal
R Glazier, K Salaita 04/09/2018 Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces.
Nano letters
PK Dutta, Y Zhang, AT Blanchard, C Ge, M Rushdi, K Weiss, C Zhu, Y Ke, K Salaita 08/08/2018 A brighter force gauge for cells.
eLife
VP Ma, K Salaita 19/07/2018 Advanced healthcare materials
K Galior, VP Ma, Y Liu, H Su, N Baker, RA Panettieri, C Wongtrakool, K Salaita 01/07/2018 Light-Responsive Polymer Particles as Force Clamps for the Mechanical Unfolding of Target Molecules.
Nano letters
H Su, Z Liu, Y Liu, VP Ma, A Blanchard, J Zhao, K Galior, RB Dyer, K Salaita 11/04/2018 Mapping the 3D orientation of piconewton integrin traction forces.
Nature methods
JM Brockman, AT Blanchard, V Pui-Yan, WD Derricotte, Y Zhang, ME Fay, WA Lam, FA Evangelista, AL Mattheyses, K Salaita 01/02/2018 Site-Selective RNA Splicing Nanozyme: DNAzyme and RtcB Conjugates on a Gold Nanoparticle.
ACS chemical biology
JR Petree, K Yehl, K Galior, R Glazier, B Deal, K Salaita 19/01/2018 Proceedings of the National Academy of Sciences of the United States of America
Y Zhang, Y Qiu, AT Blanchard, Y Chang, JM Brockman, VP Ma, WA Lam, K Salaita 09/01/2018 Molecular Tension Probes for Imaging Forces at the Cell Surface.
Accounts of chemical research
Y Liu, K Galior, VP Ma, K Salaita 19/12/2017 Supported lipid bilayer platforms to probe cell mechanobiology.
Biochimica et biophysica acta. Biomembranes
R Glazier, K Salaita 01/09/2017 Nature communications
J Konen, E Summerbell, B Dwivedi, K Galior, Y Hou, L Rusnak, A Chen, J Saltz, W Zhou, LH Boise, P Vertino, L Cooper, K Salaita, J Kowalski, AI Marcus 12/05/2017 Ratiometric Tension Probes for Mapping Receptor Forces and Clustering at Intermembrane Junctions.
Nano letters
VP Ma, Y Liu, L Blanchfield, H Su, BD Evavold, K Salaita 13/07/2016 Proceedings of the National Academy of Sciences of the United States of America
Y Liu, L Blanchfield, VP Ma, R Andargachew, K Galior, Z Liu, B Evavold, K Salaita 17/05/2016 Angewandte Chemie (International ed. in English)
VP Ma, Y Liu, K Yehl, K Galior, Y Zhang, K Salaita 25/04/2016 Journal of the American Chemical Society
Y Chang, Z Liu, Y Zhang, K Galior, J Yang, K Salaita 09/03/2016 Biomaterials
I Somasuntharam, K Yehl, SL Carroll, JT Maxwell, MD Martinez, PL Che, ME Brown, K Salaita, ME Davis 01/03/2016 Nanoscale optomechanical actuators for controlling mechanotransduction in living cells.
Nature methods
Z Liu, Y Liu, Y Chang, HR Seyf, A Henry, AL Mattheyses, K Yehl, Y Zhang, Z Huang, K Salaita 01/02/2016 High-speed DNA-based rolling motors powered by RNase H.
Nature nanotechnology
K Yehl, A Mugler, S Vivek, Y Liu, Y Zhang, M Fan, ER Weeks, K Salaita 01/02/2016 Titin-Based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions.
Nano letters
K Galior, Y Liu, K Yehl, S Vivek, K Salaita 13/01/2016 Real-time fluorescence imaging with 20 nm axial resolution.
Nature communications
DR Stabley, T Oh, SM Simon, AL Mattheyses, K Salaita 22/09/2015 Molecular and cellular biology
C Jurchenko, KS Salaita 01/08/2015 DNA-based digital tension probes reveal integrin forces during early cell adhesion.
Nature communications
Y Zhang, C Ge, C Zhu, K Salaita 24/10/2014 Nano letters
Y Liu, R Medda, Z Liu, K Galior, K Yehl, JP Spatz, EA Cavalcanti-Adam, K Salaita 08/10/2014 The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation.
Biomaterials
AV Boopathy, PL Che, I Somasuntharam, VF Fiore, EB Cabigas, K Ban, ME Brown, Y Narui, TH Barker, YS Yoon, K Salaita, AJ García, ME Davis 01/09/2014 Integrin-generated forces lead to streptavidin-biotin unbinding in cellular adhesions.
Biophysical journal
C Jurchenko, Y Chang, Y Narui, Y Zhang, KS Salaita 01/04/2014 Structurally defined nanoscale sheets from self-assembly of collagen-mimetic peptides.
Journal of the American Chemical Society
T Jiang, C Xu, Y Liu, Z Liu, JS Wall, X Zuo, T Lian, K Salaita, C Ni, D Pochan, VP Conticello 19/03/2014 Journal of the American Chemical Society
W Zheng, Y Liu, A West, EE Schuler, K Yehl, RB Dyer, JT Kindt, K Salaita 05/02/2014 Biophysical journal
Y Narui, K Salaita 17/12/2013 Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface.
Journal of the American Chemical Society
Y Liu, K Yehl, Y Narui, K Salaita 10/04/2013 Integrative biology : quantitative biosciences from nano to macro
D Stabley, S Retterer, S Marshall, K Salaita 01/04/2013 Catalytic deoxyribozyme-modified nanoparticles for RNAi-independent gene regulation.
ACS nano
K Yehl, JP Joshi, BL Greene, RB Dyer, R Nahta, K Salaita 23/10/2012 Visualizing mechanical tension across membrane receptors with a fluorescent sensor.
Nature methods
DR Stabley, C Jurchenko, SS Marshall, KS Salaita 30/10/2011 The Journal of biological chemistry
H Laroui, Y Yan, Y Narui, SA Ingersoll, S Ayyadurai, MA Charania, F Zhou, B Wang, K Salaita, SV Sitaraman, D Merlin 02/09/2011 American journal of physiology. Gastrointestinal and liver physiology
H Laroui, DS Wilson, G Dalmasso, K Salaita, N Murthy, SV Sitaraman, D Merlin 01/03/2011 Roles of the cytoskeleton in regulating EphA2 signals.
Communicative & integrative biology
K Salaita, JT Groves 01/09/2010 Awards
Dr. Salaita has earned the following awards and honors:
- Camille Dreyfus Teacher-Scholar Award, 2014
- NSF Early CAREER Award, 2014
- Alfred P. Sloan Research Fellow, 2013
- Cancer Research Award, Georgia Cancer Coalition, 2010