John A. Petros, MD
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Research Program
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Phone Number
John A. Petros, MD, is a professor and the associate chair of research in the Department of Urology at Emory University School of Medicine. Dr. Petros holds secondary academic appointments as a professor in the Department of Hematology and Medical Oncology and Department of Pathology and Laboratory Medicine at Emory.
In 1993, Dr. Petros joined Emory as an academic faculty urologist and scientist. He is a Diplomate of the American Board of Urology. Since 1993, Dr. Petros has been both a practicing urologist and the principal investigator of a basic science laboratory for the entire time he has been at Emory. While taking care of patients every week he has maintained continuous extramural funding for his laboratory for over 20 years.
Dr. Petros received an Artium Baccalaureatus (AB) Degree from Washington University in St. Louis Missouri majoring in Chemistry and Biology. He attended medical school at Loyola University Stritch School of Medicine in Chicago, Illinois. He completed his urology residency training at Washington University, Barnes Hospital, in St. Louis, Missouri.
Dr. Petros is most well known for pioneering the field of mitochondrial DNA (mtDNA) mutations in prostate cancer having been the first to show that inherited mutations of this genome result in increased likelihood of developing prostate cancer. Major contributions to this field have included showing that mtDNA mutations exert their cancer promoting influence by altering the production of cellular reactive oxygen and reactive nitrogen species, which in turn activate a cascade of tumor-promoting molecular events. The ultimate clinical translation of these findings may be the development of novel therapies targeting these molecules. This research also holds the promise of patient-individualized (personalized) medicine in that individuals could be identified that have inherited these gene mutations and selected for more intensive screening and early treatment. Dr. Petros found that mutations in the mtDNA are much more common in African Americans with prostate cancer than Caucasian Americans with prostate cancer. This may be responsible for some of the health disparities in this disease where African American men are at higher risk for developing and/or dying of prostate cancer. In addition, Dr. Petros is conducting research designed to develop a new diagnostic blood or urine test for kidney cancer.
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Title/Journal | Authors | Publication Date |
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Genetics |
JS Brockett, T Manalo, H Zein-Sabatto, J Lee, J Fang, P Chu, H Feng, D Patil, P Davidson, K Ogan, VA Master, JG Pattaras, DL Roberts, SH Bergquist, MA Reyna, JA Petros, DA Lerit, RS Arnold | 03/04/2024 |
bioRxiv : the preprint server for biology |
B Wu, S Tapadar, Z Ruan, CQ Sun, RS Arnold, JO Olugbami, A Johnston, U Arunsi, DA Gaul, JA Petros, T Kobayashi, DG Duda, AK Oyelere | 28/03/2024 |
ACS pharmacology & translational science |
M Dasari, SC Pelly, J Geng, HB Gold, N Pribut, SK Sharma, MP D'Erasmo, PW Bartsch, C Sun, K Toti, RS Arnold, JA Petros, L Xu, Y Jiang, EJ Miller, DC Liotta | 12/05/2023 |
Cancers |
OO Bifarin, DA Gaul, S Sah, RS Arnold, K Ogan, VA Master, DL Roberts, SH Bergquist, JA Petros, AS Edison, FM Fernández | 13/12/2021 |
Journal of proteome research |
OO Bifarin, DA Gaul, S Sah, RS Arnold, K Ogan, VA Master, DL Roberts, SH Bergquist, JA Petros, FM Fernández, AS Edison | 02/07/2021 |
Cancers |
S Tapadar, S Fathi, B Wu, CQ Sun, I Raji, SG Moore, RS Arnold, DA Gaul, JA Petros, AK Oyelere | 23/10/2020 |
International journal of urology : official journal of the Japanese Urological Association |
RC Obeng, RS Arnold, K Ogan, VA Master, JG Pattaras, JA Petros, AO Osunkoya | 01/09/2020 |
Translational oncology |
Z Li, C Sun, S Tao, AO Osunkoya, RS Arnold, JA Petros, X Zu, CS Moreno | 01/04/2020 |
Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy. Journal of proteome research |
CS Clendinen, DA Gaul, ME Monge, RS Arnold, AS Edison, JA Petros, FM Fernández | 01/03/2019 |
Cancer biology & therapy |
CQ Sun, RS Arnold, CL Hsieh, JR Dorin, F Lian, Z Li, JA Petros | 01/01/2019 |
Cancers |
NV Sharma, KL Pellegrini, V Ouellet, FO Giuste, S Ramalingam, K Watanabe, E Adam-Granger, L Fossouo, S You, MR Freeman, P Vertino, K Conneely, AO Osunkoya, D Trudel, AM Mes-Masson, JA Petros, F Saad, CS Moreno | 11/10/2018 |
Comparative Cost Analysis: Teleurology vs Conventional Face-to-Face Clinics. Urology |
V Zholudev, IJ Safir, MN Painter, JA Petros, CP Filson, MM Issa | 01/03/2018 |
Oncotarget |
B Grindel, Q Li, R Arnold, J Petros, M Zayzafoon, M Muldoon, J Stave, LW Chung, MC Farach-Carson | 13/09/2016 |
ACS medicinal chemistry letters |
EJ Miller, SG Mays, MT Baillie, RB Howard, DG Culver, M Saindane, ST Pruett, JJ Holt, DS Menaldino, TJ Evers, GP Reddy, RF Arrendale, MG Natchus, JA Petros, DC Liotta | 12/05/2016 |
Oncotarget |
B Grindel, Q Li, R Arnold, J Petros, M Zayzafoon, M Muldoon, J Stave, LW Chung, MC Farach-Carson | 01/03/2016 |
A mitochondrial DNA mutation influences the apoptotic effect of statins on prostate cancer. The Prostate |
Q Sun, RS Arnold, CQ Sun, JA Petros | 01/12/2015 |
Bone |
RS Arnold, SA Fedewa, M Goodman, AO Osunkoya, HT Kissick, C Morrissey, LD True, JA Petros | 01/09/2015 |
Mitochondrial DNA mutations in prostate cancer bone metastases. Journal of nature and science |
CG Keith, RS Arnold, JA Petros | 01/08/2015 |
von Hippel-Lindau exonic methylation analysis using MALDI-TOF mass spectrometry. The Journal of urology |
F Lian, S Sreedharan, RS Arnold, VA Master, K Ogan, JG Pattaras, DL Roberts, JA Petros | 01/11/2014 |
Oncotarget |
SY Sung, IH Wu, PH Chuang, JA Petros, HC Wu, HJ Zeng, WC Huang, LW Chung, CL Hsieh | 30/10/2014 |
Cancer research |
Q Long, J Xu, AO Osunkoya, S Sannigrahi, BA Johnson, W Zhou, T Gillespie, JY Park, RK Nam, L Sugar, A Stanimirovic, AK Seth, JA Petros, CS Moreno | 15/06/2014 |
Applied immunohistochemistry & molecular morphology : AIMM |
SH Mauzo, M Lee, J Petros, S Hunter, CM Chang, HK Shu, AC Bellail, C Hao, C Cohen | 01/04/2014 |
Disease markers |
S Sreedharan, JA Petros, VA Master, K Ogan, JG Pattaras, DL Roberts, F Lian, RS Arnold | 01/01/2014 |
International braz j urol : official journal of the Brazilian Society of Urology |
RW Dobbs, LA Hugar, LM Revenig, S Al-Qassab, JA Petros, CW Ritenour, MM Issa, DJ Canter | 01/01/2014 |
Formalin disinfection of biopsy needle minimizes the risk of sepsis following prostate biopsy. The Journal of urology |
MM Issa, UA Al-Qassab, J Hall, CW Ritenour, JA Petros, JW Sullivan | 01/11/2013 |
Journal of endourology |
AB Shrewsberry, U Al-Qassab, M Goodman, JA Petros, JW Sullivan, CW Ritenour, MM Issa | 01/08/2013 |
BioMed research international |
RS Arnold, Q Sun, CQ Sun, JC Richards, S O'Hearn, AO Osunkoya, DC Wallace, JA Petros | 01/01/2013 |
Pelvic nephroureterectomy for renal cell carcinoma in an ectopic kidney. Case reports in oncological medicine |
KG Baldie, UA Al-Qassab, CW Ritenour, MM Issa, AO Osunkoya, JA Petros | 01/01/2012 |
Mitochondrial Cytochrome c Oxidase subunit 1 Sequence Variation in Prostate Cancer. Scientifica |
TA Scott, R Arnold, JA Petros | 01/01/2012 |
The American journal of pathology |
Q Long, BA Johnson, AO Osunkoya, YH Lai, W Zhou, M Abramovitz, M Xia, MB Bouzyk, RK Nam, L Sugar, A Stanimirovic, DJ Williams, BR Leyland-Jones, AK Seth, JA Petros, CS Moreno | 01/07/2011 |
ACS medicinal chemistry letters |
EC Garnier-Amblard, SG Mays, RF Arrendale, MT Baillie, AS Bushnev, DG Culver, TJ Evers, JJ Holt, RB Howard, LS Liebeskind, DS Menaldino, MG Natchus, JA Petros, H Ramaraju, GP Reddy, DC Liotta | 09/06/2011 |
PloS one |
N Makarova, C Zhao, Y Zhang, S Bhosle, S Suppiah, JM Rhea, N Kozyr, RS Arnold, H Ly, RJ Molinaro, TG Parslow, E Hunter, D Liotta, J Petros, JL Blackwell | 06/04/2011 |
Urology |
TT Abd, M Goodman, J Hall, CW Ritenour, JA Petros, FF Marshall, MM Issa | 01/03/2011 |
Mitochondrial genotype and breast cancer predisposition. Oncology reports |
AM Czarnecka, T Krawczyk, K Plak, A Klemba, M Zdrozny, RS Arnold, B Kofler, P Golik, A Szybinska, J Lubinski, M Mossakowska, E Bartnik, JA Petros | 01/12/2010 |
Journal of virology |
S Bhosle, S Suppiah, R Molinaro, Y Liang, R Arnold, W Diehl, N Makarova, J Blackwell, J Petros, D Liotta, E Hunter, H Ly | 01/07/2010 |
Breast cancer research and treatment |
AM Czarnecka, T Krawczyk, M Zdrozny, J Lubiński, RS Arnold, W Kukwa, A Scińska, P Golik, E Bartnik, JA Petros | 01/06/2010 |
Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dots. ACS nano |
J Liu, SK Lau, VA Varma, RA Moffitt, M Caldwell, T Liu, AN Young, JA Petros, AO Osunkoya, T Krogstad, B Leyland-Jones, MD Wang, S Nie | 25/05/2010 |
Urology |
RS Arnold, NV Makarova, AO Osunkoya, S Suppiah, TA Scott, NA Johnson, SM Bhosle, D Liotta, E Hunter, FF Marshall, H Ly, RJ Molinaro, JL Blackwell, JA Petros | 01/04/2010 |
Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. Oncology reports |
AM Czarnecka, A Klemba, T Krawczyk, M Zdrozny, RS Arnold, E Bartnik, JA Petros | 01/02/2010 |
The Journal of urology |
KA Moses, TT Abd, M Goodman, W Hsiao, JA Hall, FF Marshall, JA Petros, MM Issa | 01/11/2009 |
The Prostate |
AM Ray, KA Zuhlke, AM Levin, JA Douglas, KA Cooney, JA Petros | 15/06/2009 |
Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment. The Prostate |
RS Arnold, CQ Sun, JC Richards, G Grigoriev, IM Coleman, PS Nelson, CL Hsieh, JK Lee, Z Xu, A Rogatko, AO Osunkoya, M Zayzafoon, L Chung, JA Petros | 01/01/2009 |
Human molecular genetics |
XY Dong, C Rodriguez, P Guo, X Sun, JT Talbot, W Zhou, J Petros, Q Li, RL Vessella, AS Kibel, VL Stevens, EE Calle, JT Dong | 01/04/2008 |
Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nature protocols |
Y Xing, Q Chaudry, C Shen, KY Kong, HE Zhau, LW Chung, JA Petros, RM O'Regan, MV Yezhelyev, JW Simons, MD Wang, S Nie | 01/01/2007 |
In vivo molecular and cellular imaging with quantum dots. Current opinion in biotechnology |
X Gao, L Yang, JA Petros, FF Marshall, JW Simons, S Nie | 01/02/2005 |
Nanomolecular histopathology for renal tumor classification. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference |
A Young, M Amin, J Petros, M Natan, S Nie, M Wang | 01/01/2005 |
Dr. Petros has received the following awards: