Eric Ortlund, PhD
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Research Program
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Phone Number
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Email Address
Eric Ortlund, PhD, is a professor in the Department of Biochemistry at Emory University School of Medicine. Dr. Ortlund is a member of the Discovery and Developmental Therapeutics Research Program at Winship.
Dr. Ortlund earned his PhD in Chemistry and Biochemistry from the University of South Carolina. After obtaining his PhD, Dr. Ortlund completed postdoctoral research at the University of North Carolina at Chapel Hill and a postdoctoral fellowship at Lineberger Cancer Center.
Dr. Ortlund's lab uses sophisticated structural, biochemical and cellular techniques to study how lipids and hormones regulate genes. They focus on transcription factors, enzymes and receptors that play central roles in development, cancer, stress and metabolism. The Ortlund lab also studies how tight molecular partnerships evolve.
Grant Number | Title |
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2R01DK103046-07 | Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD |
2R01DK115213-06A1 | Targeting the orphan nuclear receptor LRH-1 with small molecules |
3U54EB027690-05S1 | ACME POCT EMERGENCY COVID-19 VARIANT TESTING & INDEPENDENT TEST ASSESSMENT EVALUATION SUPPLEMENT |
5R01DK103046-08 | Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD |
5U24DK112341-06 | Georgia Comprehensive Metabolomics and Proteomics Unit for MoTrPAC |
7R01DK103046-10 | Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD |
Title/Journal | Authors | Publication Date |
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Nature metabolism |
GM Many, JA Sanford, TJ Sagendorf, Z Hou, P Nigro, KL Whytock, D Amar, T Caputo, NR Gay, DA Gaul, MF Hirshman, D Jimenez-Morales, ME Lindholm, MJ Muehlbauer, M Vamvini, BC Bergman, FM Fernández, LJ Goodyear, AL Hevener, EA Ortlund, LM Sparks, A Xia, JN Adkins, SC Bodine, CB Newgard, S Schenk | 01/05/2024 |
Research square |
E Ortlund, CY Chen, K Maner-Smith, M Khadka, J Ahn, X Gulbin, A Ivanova, E Dammer, N Seyfried, D Bennett, I Hajjar | 27/02/2024 |
Molecular and cellular endocrinology |
MR Proffitt, X Liu, EA Ortlund, GT Smith | 01/12/2023 |
iScience |
N Cheedarla, HP Verkerke, S Potlapalli, KB McLendon, A Patel, F Frank, WH O'Sick, S Cheedarla, TJ Baugh, GL Damhorst, H Wu, D Graciaa, F Hudaib, DN Alter, J Bryksin, EA Ortlund, J Guarner, S Auld, S Shah, W Lam, D Mattoon, JM Johnson, DH Wilson, MV Dhodapkar, SR Stowell, AS Neish, JD Roback | 17/11/2023 |
Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants. Journal of clinical microbiology |
A Rao, A Westbrook, L Bassit, R Parsons, E Fitts, M Greenleaf, K McLendon, JA Sullivan, W O'Sick, T Baugh, HB Bowers, F Frank, E Wang, M Le, J Frediani, P Roychoudhury, AL Greninger, R Jerris, NR Pollock, EA Ortlund, JD Roback, WA Lam, A Piantadosi | 24/10/2023 |
Protein science : a publication of the Protein Society |
SG Mays, D Hercules, EA Ortlund, CD Okafor | 01/10/2023 |
Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron. Cell reports |
A Patel, S Kumar, L Lai, M Keen, R Valanparambil, C Chakravarthy, Z Laughlin, F Frank, N Cheedarla, HP Verkerke, AS Neish, JD Roback, CW Davis, J Wrammert, A Sharma, R Ahmed, MS Suthar, K Murali-Krishna, A Chandele, E Ortlund | 26/09/2023 |
Nucleic acids research |
PE Head, P Kapoor-Vazirani, GP Nagaraju, H Zhang, SK Rath, NC Luong, R Haji-Seyed-Javadi, F Sesay, SY Wang, DM Duong, W Daddacha, EV Minten, B Song, D Danelia, X Liu, S Li, EA Ortlund, NT Seyfried, DM Smalley, Y Wang, X Deng, WS Dynan, B El-Rayes, AJ Davis, DS Yu | 25/08/2023 |
The Journal of biological chemistry |
ML Cato, EH D'Agostino, RM Spurlin, AR Flynn, JL Cornelison, AM Johnson, RA Fujita, SM Abraham, NT Jui, EA Ortlund | 01/08/2023 |
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response. Structure (London, England : 1993) |
A Patel, S Kumar, L Lai, C Chakravarthy, R Valanparambil, ES Reddy, K Gottimukkala, P Bajpai, DR Raju, VV Edara, ME Davis-Gardner, S Linderman, K Dixit, P Sharma, G Mantus, N Cheedarla, HP Verkerke, F Frank, AS Neish, JD Roback, CW Davis, J Wrammert, R Ahmed, MS Suthar, A Sharma, K Murali-Krishna, A Chandele, EA Ortlund | 06/07/2023 |
Cancer letters |
H He, A Sugiyama, NW Snyder, MG Teneche, X Liu, KM Maner-Smith, W Goessling, SJ Hagen, EA Ortlund, SH Najafi-Shoushtari, M Acuña, DE Cohen | 01/07/2023 |
APOE expression and secretion are modulated by mitochondrial dysfunction. eLife |
ME Wynne, O Ogunbona, AR Lane, A Gokhale, SA Zlatic, C Xu, Z Wen, DM Duong, S Rayaprolu, A Ivanova, EA Ortlund, EB Dammer, NT Seyfried, BR Roberts, A Crocker, V Shanbhag, M Petris, N Senoo, S Kandasamy, SM Claypool, A Barrientos, A Wingo, TS Wingo, S Rangaraju, AI Levey, E Werner, V Faundez | 12/05/2023 |
Nature communications |
SA Druzak, M Tardelli, SG Mays, M El Bejjani, X Mo, KM Maner-Smith, T Bowen, ML Cato, MC Tillman, A Sugiyama, Y Xie, H Fu, DE Cohen, EA Ortlund | 12/05/2023 |
Nature communications |
S Druzak, E Iffrig, BR Roberts, T Zhang, KS Fibben, Y Sakurai, HP Verkerke, CA Rostad, A Chahroudi, F Schneider, AKH Wong, AM Roberts, JD Chandler, SO Kim, M Mosunjac, M Mosunjac, R Geller, I Albizua, SR Stowell, CM Arthur, EJ Anderson, AA Ivanova, J Ahn, X Liu, K Maner-Smith, T Bowen, M Paiardini, SE Bosinger, JD Roback, DA Kulpa, G Silvestri, WA Lam, EA Ortlund, CL Maier | 04/04/2023 |
Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants. medRxiv : the preprint server for health sciences |
A Rao, A Westbrook, L Bassit, R Parsons, E Fitts, M Greenleaf, K McLendon, JA Sullivan, W O'Sick, T Baugh, HB Bowers, F Frank, E Wang, M Le, J Frediani, P Roychoudhury, AL Greninger, R Jerris, NR Pollock, EA Ortlund, JD Roback, WA Lam, A Piantadosi | 10/02/2023 |
bioRxiv : the preprint server for biology |
GM Many, JA Sanford, TJ Sagendorf, Z Hou, P Nigro, K Whytock, D Amar, T Caputo, NR Gay, DA Gaul, M Hirshman, D Jimenez-Morales, ME Lindholm, MJ Muehlbauer, M Vamvini, B Bergman, FM Fern Ndez, LJ Goodyear, EA Ortlund, LM Sparks, A Xia, JN Adkins, SC Bodine, CB Newgard, S Schenk | 04/02/2023 |
bioRxiv : the preprint server for biology |
SG Mays, D Hercules, EA Ortlund, CD Okafor | 28/01/2023 |
Nutrients |
KM Maner-Smith, E Ferranti, A Dunlop, E Corwin, EA Ortlund | 28/12/2022 |
Nature communications |
P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu | 07/11/2022 |
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature |
JW Blanchard, LA Akay, J Davila-Velderrain, D von Maydell, H Mathys, SM Davidson, A Effenberger, CY Chen, K Maner-Smith, I Hajjar, EA Ortlund, M Bula, E Agbas, A Ng, X Jiang, M Kahn, C Blanco-Duque, N Lavoie, L Liu, R Reyes, YT Lin, T Ko, L R'Bibo, WT Ralvenius, DA Bennett, HP Cam, M Kellis, LH Tsai | 01/11/2022 |
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response. bioRxiv : the preprint server for biology |
A Patel, S Kumar, L Lai, C Chakravarthy, R Valanparambil, ES Reddy, K Gottimukkala, P Bajpai, DR Raju, VV Edara, ME Davis-Gardner, S Linderman, K Dixit, P Sharma, G Mantus, N Cheedarla, HP Verkerke, F Frank, AS Neish, JD Roback, CW Davis, J Wrammert, R Ahmed, MS Suthar, A Sharma, K Murali-Krishna, A Chandele, EA Ortlund | 24/10/2022 |
Science advances |
S Kumar, A Patel, L Lai, C Chakravarthy, R Valanparambil, ES Reddy, K Gottimukkala, ME Davis-Gardner, VV Edara, S Linderman, K Nayak, K Dixit, P Sharma, P Bajpai, V Singh, F Frank, N Cheedarla, HP Verkerke, AS Neish, JD Roback, G Mantus, PK Goel, M Rahi, CW Davis, J Wrammert, S Godbole, AR Henry, DC Douek, MS Suthar, R Ahmed, E Ortlund, A Sharma, K Murali-Krishna, A Chandele | 07/10/2022 |
Cell |
F Frank, MM Keen, A Rao, L Bassit, X Liu, HB Bowers, AB Patel, ML Cato, JA Sullivan, M Greenleaf, A Piantadosi, WA Lam, WH Hudson, EA Ortlund | 15/09/2022 |
A phospholipid mimetic targeting LRH-1 ameliorates colitis. Cell chemical biology |
SG Mays, EH D'Agostino, AR Flynn, X Huang, G Wang, X Liu, EJ Millings, CD Okafor, A Patel, ML Cato, JL Cornelison, D Melchers, R Houtman, DD Moore, JW Calvert, NT Jui, EA Ortlund | 21/07/2022 |
Lysosome lipid signalling from the periphery to neurons regulates longevity. Nature cell biology |
M Savini, A Folick, YT Lee, F Jin, A Cuevas, MC Tillman, JD Duffy, Q Zhao, IA Neve, PW Hu, Y Yu, Q Zhang, Y Ye, WB Mair, J Wang, L Han, EA Ortlund, MC Wang | 01/06/2022 |
Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing. Cell reports methods |
S Farmer, V Razin, AF Peagler, S Strickler, WB Fain, GL Damhorst, RR Kempker, NR Pollock, O Brand, B Seitter, SS Heilman, EJ Nehl, JM Levy, DS Gottfried, GS Martin, M Greenleaf, DN Ku, JJ Waggoner, E Iffrig, RG Mannino, Y F Wang, E Ortlund, J Sullivan, PA Rebolledo, V Clavería, JD Roback, M Benoit, C Stone, A Esper, F Frank, WA Lam | 23/05/2022 |
Journal of medicinal chemistry |
ML Cato, JL Cornelison, RM Spurlin, VV Courouble, AB Patel, AR Flynn, AM Johnson, CD Okafor, F Frank, EH D'Agostino, PR Griffin, NT Jui, EA Ortlund | 12/05/2022 |
Research square |
N Cheedarla, HP Verkerke, S Potlapalli, KB McLendon, A Patel, F Frank, GL Damhorst, H Wu, WH O'Sick, D Graciaa, F Hudaib, DN Alter, J Bryksin, EA Ortlund, J Guarner, S Auld, S Shah, W Lam, D Mattoon, JM Johnson, DH Wilson, MV Dhodapkar, SR Stowell, AS Neish, JD Roback | 16/02/2022 |
medRxiv : the preprint server for health sciences |
N Cheedarla, HP Verkerke, S Potlapalli, KB McLendon, A Patel, F Frank, GL Damhorst, H Wu, WH Oâ Sick, D Graciaa, F Hudaib, DN Alter, J Bryksin, EA Ortlund, J Guarner, S Auld, S Shah, W Lam, D Mattoon, JM Johnson, DH Wilson, MV Dhodapkar, SR Stowell, AS Neish, JD Roback | 02/02/2022 |
Hepatology (Baltimore, Md.) |
N Imai, HT Nicholls, M Alves-Bezerra, Y Li, AA Ivanova, EA Ortlund, DE Cohen | 01/01/2022 |
Journal of lipids |
MM Heintz, R Kumar, KM Maner-Smith, EA Ortlund, WS Baldwin | 01/01/2022 |
Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity. PloS one |
MM Heintz, JA Eccles, EM Olack, KM Maner-Smith, EA Ortlund, WS Baldwin | 01/01/2022 |
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen. Nature metabolism |
KH Liu, JA Owens, B Saeedi, CE Cohen, MP Bellissimo, C Naudin, T Darby, S Druzak, K Maner-Smith, M Orr, X Hu, J Fernandes, MC Camacho, S Hunter-Chang, D VanInsberghe, C Ma, T Ganesh, SM Yeligar, K Uppal, YM Go, JA Alvarez, MB Vos, TR Ziegler, MH Woodworth, CS Kraft, RM Jones, E Ortlund, AS Neish, DP Jones | 01/12/2021 |
Structural insights into glucocorticoid receptor function. Biochemical Society transactions |
F Frank, EA Ortlund, X Liu | 01/11/2021 |
Nucleic acids research |
X Liu, ER Weikum, D Tilo, C Vinson, EA Ortlund | 07/09/2021 |
TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis. PLoS pathogens |
JM Collins, DP Jones, A Sharma, M Khadka, KH Liu, RR Kempker, B Prideaux, K Maner-Smith, N Tukvadze, NS Shah, JCM Brust, RP Sékaly, NR Gandhi, HM Blumberg, EA Ortlund, TR Ziegler | 01/09/2021 |
Proceedings of the National Academy of Sciences of the United States of America |
F Frank, X Liu, EA Ortlund | 27/07/2021 |
Nature communications |
Y Li, N Imai, HT Nicholls, BR Roberts, S Goyal, TI Krisko, LH Ang, MC Tillman, AM Roberts, M Baqai, EA Ortlund, DE Cohen, SJ Hagen | 09/06/2021 |
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nature chemical biology |
NE Bruno, JC Nwachukwu, S Srinivasan, CC Nettles, T Izard, Z Jin, J Nowak, MD Cameron, SV Boregowda, DG Phinney, O Elemento, X Liu, EA Ortlund, R Houtman, DA Stavreva, GL Hager, TM Kamenecka, DJ Kojetin, KW Nettles | 01/03/2021 |
IEEE open journal of engineering in medicine and biology |
R Creager, J Blackwood, T Pribyl, L Bassit, A Rao, M Greenleaf, F Frank, W Lam, E Ortlund, R Schinazi, A Greninger, M Cirrincione, D Gort, E Kennedy, A Samuta, M Shaw, B Walsh, E Lai | 01/01/2021 |
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of biological chemistry |
KE Squires, KJ Gerber, MC Tillman, DJ Lustberg, C Montañez-Miranda, M Zhao, S Ramineni, CD Scharer, RN Saha, FJ Shu, JP Schroeder, EA Ortlund, D Weinshenker, SM Dudek, JR Hepler | 01/01/2021 |
Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist. Scientific reports |
SG Mays, J Stec, X Liu, EH D'Agostino, RJ Whitby, EA Ortlund | 17/12/2020 |
Nature communications |
JC Moody, H Qadota, AR Reedy, CD Okafor, N Shanmugan, Y Matsunaga, CJ Christian, EA Ortlund, GM Benian | 06/10/2020 |
Proceedings of the National Academy of Sciences of the United States of America |
X Liu, Y Wang, JS Gutierrez, JM Damsker, K Nagaraju, EP Hoffman, EA Ortlund | 29/09/2020 |
Proceedings of the National Academy of Sciences of the United States of America |
MC Tillman, N Imai, Y Li, M Khadka, CD Okafor, P Juneja, A Adhiyaman, SJ Hagen, DE Cohen, EA Ortlund | 08/09/2020 |
Hepatology (Baltimore, Md.) |
S Steensels, J Qiao, Y Zhang, KM Maner-Smith, N Kika, CD Holman, KE Corey, WC Bracken, EA Ortlund, BA Ersoy | 01/09/2020 |
A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird. Proceedings of the National Academy of Sciences of the United States of America |
JR Merritt, KE Grogan, WM Zinzow-Kramer, D Sun, EA Ortlund, SV Yi, DL Maney | 01/09/2020 |
Bioorganic & medicinal chemistry letters |
JL Cornelison, ML Cato, AM Johnson, EH D'Agostino, D Melchers, AB Patel, SG Mays, R Houtman, EA Ortlund, NT Jui | 15/08/2020 |
Gastroenterology |
CR Naudin, K Maner-Smith, JA Owens, GM Wynn, BS Robinson, JD Matthews, AR Reedy, L Luo, AA Wolfarth, TM Darby, EA Ortlund, RM Jones | 01/08/2020 |
Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination. Vaccines |
KM Maner-Smith, JB Goll, M Khadka, TL Jensen, JK Colucci, CE Gelber, CJ Albert, SE Bosinger, JD Franke, M Natrajan, N Rouphael, RA Johnson, P Sanz, EJ Anderson, DF Hoft, MJ Mulligan, DA Ford, EA Ortlund | 24/07/2020 |
Cell reports |
F Frank, N Kavousi, A Bountali, EB Dammer, M Mourtada-Maarabouni, EA Ortlund | 21/07/2020 |
Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell reports. Medicine |
MS Suthar, MG Zimmerman, RC Kauffman, G Mantus, SL Linderman, WH Hudson, A Vanderheiden, L Nyhoff, CW Davis, O Adekunle, M Affer, M Sherman, S Reynolds, HP Verkerke, DN Alter, J Guarner, J Bryksin, MC Horwath, CM Arthur, N Saakadze, GH Smith, S Edupuganti, EM Scherer, K Hellmeister, A Cheng, JA Morales, AS Neish, SR Stowell, F Frank, E Ortlund, EJ Anderson, VD Menachery, N Rouphael, AK Mehta, DS Stephens, R Ahmed, JD Roback, J Wrammert | 23/06/2020 |
Rapid generation of neutralizing antibody responses in COVID-19 patients. medRxiv : the preprint server for health sciences |
MS Suthar, M Zimmerman, R Kauffman, G Mantus, S Linderman, A Vanderheiden, L Nyhoff, C Davis, S Adekunle, M Affer, M Sherman, S Reynolds, H Verkerke, DN Alter, J Guarner, J Bryksin, M Horwath, C Arthur, N Saakadze, GH Smith, S Edupuganti, EM Scherer, K Hellmeister, A Cheng, JA Morales, AS Neish, SR Stowell, F Frank, E Ortlund, E Anderson, V Menachery, N Rouphael, A Metha, DS Stephens, R Ahmed, J Roback, J Wrammert | 08/05/2020 |
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science (New York, N.Y.) |
NH Knudsen, KJ Stanya, AL Hyde, MM Chalom, RK Alexander, YH Liou, KA Starost, MR Gangl, D Jacobi, S Liu, DH Sopariwala, D Fonseca-Pereira, J Li, FB Hu, WS Garrett, VA Narkar, EA Ortlund, JH Kim, CM Paton, JA Cooper, CH Lee | 01/05/2020 |
ACS medicinal chemistry letters |
EH D'Agostino, AR Flynn, JL Cornelison, SG Mays, A Patel, NT Jui, EA Ortlund | 12/03/2020 |
Structure (London, England : 1993) |
CD Okafor, D Hercules, SA Kell, EA Ortlund | 04/02/2020 |
Cellular and molecular gastroenterology and hepatology |
AA Wolfarth, X Liu, TM Darby, DJ Boyer, JB Spizman, JA Owens, B Chandrasekharan, CR Naudin, KZ Hanley, BS Robinson, EA Ortlund, RM Jones, AS Neish | 01/01/2020 |
Journal of medicinal chemistry |
SG Mays, AR Flynn, JL Cornelison, CD Okafor, H Wang, G Wang, X Huang, HN Donaldson, EJ Millings, R Polavarapu, DD Moore, JW Calvert, NT Jui, EA Ortlund | 26/12/2019 |
Molecular pharmacology |
X Liu, Y Wang, EA Ortlund | 01/10/2019 |
Hepatology (Baltimore, Md.) |
M Alves-Bezerra, Y Li, M Acuña, AA Ivanova, KE Corey, EA Ortlund, DE Cohen | 01/08/2019 |
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. Scientific reports |
MC Tillman, M Khadka, J Duffy, MC Wang, EA Ortlund | 10/07/2019 |
Biomolecules |
M Khadka, A Todor, KM Maner-Smith, JK Colucci, V Tran, DA Gaul, EJ Anderson, MS Natrajan, N Rouphael, MJ Mulligan, CE McDonald, M Suthar, S Li, EA Ortlund | 23/05/2019 |
Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. JCI insight |
RJ Cordy, R Patrapuvich, LN Lili, M Cabrera-Mora, JT Chien, GK Tharp, M Khadka, EV Meyer, SA Lapp, CJ Joyner, A Garcia, S Banton, V Tran, V Luvira, S Rungin, T Saeseu, N Rachaphaew, SB Pakala, JD DeBarry, JC Kissinger, EA Ortlund, SE Bosinger, JW Barnwell, DP Jones, K Uppal, S Li, J Sattabongkot, A Moreno, MR Galinski | 02/05/2019 |
The nuclear receptor superfamily: A structural perspective. Protein science : a publication of the Protein Society |
ER Weikum, X Liu, EA Ortlund | 01/11/2018 |
Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1. ACS medicinal chemistry letters |
AR Flynn, SG Mays, EA Ortlund, NT Jui | 11/10/2018 |
Delimiting the autoinhibitory module of von Willebrand factor. Journal of thrombosis and haemostasis : JTH |
W Deng, KM Voos, JK Colucci, ER Legan, EA Ortlund, P Lollar, R Li | 01/10/2018 |
Scientific reports |
F Frank, CD Okafor, EA Ortlund | 10/09/2018 |
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity |
P Mandal, Y Feng, JD Lyons, SB Berger, S Otani, A DeLaney, GK Tharp, K Maner-Smith, EM Burd, M Schaeffer, S Hoffman, C Capriotti, L Roback, CB Young, Z Liang, EA Ortlund, NC DiPaolo, S Bosinger, J Bertin, PJ Gough, IE Brodsky, CM Coopersmith, DM Shayakhmetov, ES Mocarski | 17/07/2018 |
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nature communications |
WH Hudson, IMS Vera, JC Nwachukwu, ER Weikum, AG Herbst, Q Yang, DL Bain, KW Nettles, DJ Kojetin, EA Ortlund | 06/04/2018 |
Structure (London, England : 1993) |
CD Okafor, MC Pathak, CE Fagan, NC Bauer, MF Cole, EA Gaucher, EA Ortlund | 02/01/2018 |
PloS one |
JM Collins, DI Walker, DP Jones, N Tukvadze, KH Liu, VT Tran, K Uppal, JK Frediani, KA Easley, N Shenvi, M Khadka, EA Ortlund, RR Kempker, HM Blumberg, TR Ziegler | 01/01/2018 |
Journal of molecular biology |
JW Francis, D Goswami, SJ Novick, BD Pascal, ER Weikum, EA Ortlund, PR Griffin, RA Kahn | 24/11/2017 |
Nucleic acids research |
ER Weikum, IMS de Vera, JC Nwachukwu, WH Hudson, KW Nettles, DJ Kojetin, EA Ortlund | 21/08/2017 |
Molecular pharmacology |
ER Weikum, CD Okafor, EH D'Agostino, JK Colucci, EA Ortlund | 01/07/2017 |
Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex. Molecular pharmacology |
SG Mays, CD Okafor, ML Tuntland, RJ Whitby, V Dharmarajan, J Stec, PR Griffin, EA Ortlund | 01/07/2017 |
Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nature reviews. Molecular cell biology |
ER Weikum, MT Knuesel, EA Ortlund, KR Yamamoto | 01/03/2017 |
Journal of molecular biology |
ER Weikum, ML Tuntland, MN Murphy, EA Ortlund | 04/12/2016 |
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists. The Journal of biological chemistry |
SG Mays, CD Okafor, RJ Whitby, D Goswami, J Stec, AR Flynn, MC Dugan, NT Jui, PR Griffin, EA Ortlund | 02/12/2016 |
Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity. The Journal of biological chemistry |
PM Musille, BR Kossmann, JA Kohn, I Ivanov, EA Ortlund | 15/01/2016 |
Proceedings of the National Academy of Sciences of the United States of America |
WH Hudson, BR Kossmann, IM de Vera, SW Chuo, ER Weikum, GN Eick, JW Thornton, IN Ivanov, DJ Kojetin, EA Ortlund | 12/01/2016 |
Identification of a lipid scrambling domain in ANO6/TMEM16F. eLife |
K Yu, JM Whitlock, K Lee, EA Ortlund, YY Cui, HC Hartzell | 09/06/2015 |
Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). The Journal of biological chemistry |
NE Brown, D Goswami, MR Branch, S Ramineni, EA Ortlund, PR Griffin, JR Hepler | 03/04/2015 |
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science (New York, N.Y.) |
A Folick, HD Oakley, Y Yu, EH Armstrong, M Kumari, L Sanor, DD Moore, EA Ortlund, R Zechner, MC Wang | 02/01/2015 |
Nature communications |
WH Hudson, MR Pickard, IM de Vera, EG Kuiper, M Mourtada-Maarabouni, GL Conn, DJ Kojetin, GT Williams, EA Ortlund | 07/11/2014 |
The structure, function and evolution of proteins that bind DNA and RNA. Nature reviews. Molecular cell biology |
WH Hudson, EA Ortlund | 01/11/2014 |
Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell |
AN McKeown, JT Bridgham, DW Anderson, MN Murphy, EA Ortlund, JW Thornton | 25/09/2014 |
The Journal of biological chemistry |
EH Armstrong, D Goswami, PR Griffin, N Noy, EA Ortlund | 23/05/2014 |
Identification of a small molecular insulin receptor agonist with potent antidiabetes activity. Diabetes |
G Qiang, S Xue, JJ Yang, G Du, X Pang, X Li, D Goswami, PR Griffin, EA Ortlund, CB Chan, K Ye | 01/04/2014 |
Evolutionary history and metabolic insights of ancient mammalian uricases. Proceedings of the National Academy of Sciences of the United States of America |
JT Kratzer, MA Lanaspa, MN Murphy, C Cicerchi, CL Graves, PA Tipton, EA Ortlund, RJ Johnson, EA Gaucher | 11/03/2014 |
Molecular biology of the cell |
J Ren, C Pei-Chen Lin, MC Pathak, BR Temple, AH Nile, CJ Mousley, MC Duncan, DM Eckert, TJ Leiker, PT Ivanova, DS Myers, RC Murphy, HA Brown, J Verdaasdonk, KS Bloom, EA Ortlund, AM Neiman, VA Bankaitis | 01/03/2014 |
Structure of glycerol dehydrogenase from Serratia. Acta crystallographica. Section F, Structural biology communications |
P Musille, E Ortlund | 01/02/2014 |
Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes. Proceedings of the National Academy of Sciences of the United States of America |
BM Horton, WH Hudson, EA Ortlund, S Shirk, JW Thomas, ER Young, WM Zinzow-Kramer, DL Maney | 28/01/2014 |
PLoS genetics |
JT Bridgham, J Keay, EA Ortlund, JW Thornton | 01/01/2014 |
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PloS one |
WH Hudson, C Youn, EA Ortlund | 01/01/2014 |
Expression, purification and crystallization of the ancestral androgen receptor-DHT complex. Acta crystallographica. Section F, Structural biology and crystallization communications |
JK Colucci, EA Ortlund | 01/09/2013 |
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors. The Journal of biological chemistry |
PM Musille, M Pathak, JL Lauer, PR Griffin, EA Ortlund | 12/07/2013 |
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proceedings of the National Academy of Sciences of the United States of America |
MJ Harms, GN Eick, D Goswami, JK Colucci, PR Griffin, EA Ortlund, JW Thornton | 09/07/2013 |
Phospholipid--driven gene regulation. FEBS letters |
PM Musille, JA Kohn, EA Ortlund | 17/04/2013 |
Hydrophobic environment is a key factor for the stability of thermophilic proteins. Proteins |
MM Gromiha, MC Pathak, K Saraboji, EA Ortlund, EA Gaucher | 01/04/2013 |
The structural basis of direct glucocorticoid-mediated transrepression. Nature structural & molecular biology |
WH Hudson, C Youn, EA Ortlund | 01/01/2013 |
PloS one |
JK Colucci, EA Ortlund | 01/01/2013 |
ChemMedChem |
J Rey, H Hu, F Kyle, CF Lai, L Buluwela, RC Coombes, EA Ortlund, S Ali, JP Snyder, AG Barrett | 01/11/2012 |
Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors. The Journal of biological chemistry |
JA Kohn, K Deshpande, EA Ortlund | 11/05/2012 |
Nature structural & molecular biology |
PM Musille, M Pathak, JL Lauer, WH Hudson, PR Griffin, EA Ortlund | 15/04/2012 |
Evolution of minimal specificity and promiscuity in steroid hormone receptors. PLoS genetics |
GN Eick, JK Colucci, MJ Harms, EA Ortlund, JW Thornton | 01/01/2012 |
Acta crystallographica. Section F, Structural biology and crystallization communications |
J Ren, G Schaaf, VA Bankaitis, EA Ortlund, MC Pathak | 01/10/2011 |
The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells. Breast cancer research and treatment |
PT Thiruchelvam, CF Lai, H Hua, RS Thomas, A Hurtado, W Hudson, AR Bayly, FJ Kyle, M Periyasamy, A Photiou, AC Spivey, EA Ortlund, RJ Whitby, JS Carroll, RC Coombes, L Buluwela, S Ali | 01/06/2011 |
Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor. PLoS genetics |
SM Carroll, EA Ortlund, JW Thornton | 01/06/2011 |
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature |
JM Lee, YK Lee, JL Mamrosh, SA Busby, PR Griffin, MC Pathak, EA Ortlund, DD Moore | 25/05/2011 |
Molecular biology of the cell |
G Schaaf, M Dynowski, CJ Mousley, SD Shah, P Yuan, EM Winklbauer, MK de Campos, K Trettin, MC Quinones, TI Smirnova, LL Yanagisawa, EA Ortlund, VA Bankaitis | 15/03/2011 |
PLoS biology |
JT Bridgham, GN Eick, C Larroux, K Deshpande, MJ Harms, ME Gauthier, EA Ortlund, BM Degnan, JW Thornton | 05/10/2010 |
Proceedings of the National Academy of Sciences of the United States of America |
F Chen, EA Gaucher, NA Leal, D Hutter, SA Havemann, S Govindarajan, EA Ortlund, SA Benner | 02/02/2010 |
An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature |
JT Bridgham, EA Ortlund, JW Thornton | 24/09/2009 |
Molecular cell |
G Schaaf, EA Ortlund, KR Tyeryar, CJ Mousley, KE Ile, TA Garrett, J Ren, MJ Woolls, CR Raetz, MR Redinbo, VA Bankaitis | 01/02/2008 |
Dr. Ortlund's awards and honors include the following: