Shoichiro Ono, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-3916
Email Address

sono@emory.edu

Biography

Shoichiro Ono, PhD, holds joint appointments as associate professor in the Department of Pathology and Laboratory Medicine and Department of Cell Biology at Emory University School of Medicine. Dr. Ono serves on the Executive Committee of the Biochemistry, Cell and Developmental Biology Graduate Program at the Emory Laney Graduate School's Division of Biological and Biomedical Sciences.

Dr. Ono is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Ono obtained his PhD and his MSc from Chiba University in Chiba, Japan.

Titles & Roles

Associate Professor, Department of Pathology and Laboratory Medicine

Emory University School of Medicine
Associate Professor, Department of Cell Biology

Emory University School of Medicine

Research

Dr. Ono's research interests are in the following areas:

Cytoskeleton-Cell Biology - His lab is interested in the mechanisms of the regulation of actin cytoskeletal dynamics. Actin filaments are reorganized during development, cell migration, and cell division. Proper regulation of the actin reorganization is required for normal cellular activities, while its misregulation often causes diseases. They have been studying functions of actin-binding proteins using biochemical, cell biological, and genetic techniques.
Alternative pre-mRNA splicing - A number of genes produce multiple transcripts by alternative splicing. Misregulation of this mechanism is involved in the pathogenesis of myotonic dystrophy. Dr. Ono's lab has identified a muscle-specific regulator of pre-mRNA splicing in the nematode C. elegans and have been studying how this splicing factor functions. This splicing factor is conserved in humans, and they hope to gain insights into the mechanism of tissue-specific pre-mRNA splicing.

Grants

View Grants

Grant Number	Title
5R01AR048615-20	Regulation of actin dynamics during myofibril assembly

Publications

Dr. Ono has extensive publications in major peer-reviewed journals. He also serves on the editorial boards of Journal of Biological Chemistry, Cytoskeleton, Cell Health and Cytoskeleton, Advanced Studies in Biology, BioMed Research International: Cell Biology Section, and International Journal of Cell Biology.

Title/Journal	Authors	Publication Date
Segregated localization of two calponin-related proteins within sarcomeric thin filaments in Caenorhabditis elegans striated muscle. Cytoskeleton (Hoboken, N.J.)	S Ono	01/01/2024
The α-arrestin SUP-13/ARRD-15 promotes isoform turnover of actin-interacting protein 1 in Caenorhabditis elegans striated muscle. PNAS nexus	M Lewis, K Ono, Z Qin, RC Johnsen, DL Baillie, S Ono	01/10/2023
Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments. Frontiers in cell and developmental biology	S Ono, E Watabe, K Morisaki, K Ono, H Kuroyanagi	01/01/2023
Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle. European journal of cell biology	S Ono, M Lewis, K Ono	01/04/2022
Imaging of Actin Cytoskeleton in the Nematode Caenorhabditis elegans. Methods in molecular biology (Clifton, N.J.)	S Ono	01/01/2022
Diversification of the calponin family proteins by gene amplification and repeat expansion of calponin-like motifs. Cytoskeleton (Hoboken, N.J.)	S Ono	01/05/2021
Native cyclase-associated protein and actin from Xenopus laevis oocytes form a unique 4:4 complex with a tripartite structure. The Journal of biological chemistry	N Kodera, H Abe, PDN Nguyen, S Ono	01/01/2021
Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex. Biomechanics and modeling in mechanobiology	Z Li, H Lee, SG Eskin, S Ono, C Zhu, LV McIntire	01/10/2020
Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction. The Journal of biological chemistry	S Ono, K Ono	21/08/2020
Cofilin-induced structural changes in actin filaments stay local. Proceedings of the National Academy of Sciences of the United States of America	S Ono	18/02/2020
Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans. The FEBS journal	K Ono, Z Qin, RC Johnsen, DL Baillie, S Ono	01/02/2020
Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion. Molecular and cellular biology	H Zhang, A Ramsey, Y Xiao, U Karki, JY Xie, J Xu, T Kelly, S Ono, GL Zhou	30/01/2020
Publisher Correction: An actin-based viscoplastic lock ensures progressive body-axis elongation. Nature	A Lardennois, G Pásti, T Ferraro, F Llense, P Mahou, J Pontabry, D Rodriguez, S Kim, S Ono, E Beaurepaire, C Gally, M Labouesse	01/10/2019
An actin-based viscoplastic lock ensures progressive body-axis elongation. Nature	A Lardennois, G Pásti, T Ferraro, F Llense, P Mahou, J Pontabry, D Rodriguez, S Kim, S Ono, E Beaurepaire, C Gally, M Labouesse	01/09/2019
Publisher Correction: An actin-based viscoplastic lock ensures progressive body-axis elongation. Nature	A Lardennois, G Pásti, T Ferraro, F Llense, P Mahou, J Pontabry, D Rodriguez, S Kim, S Ono, E Beaurepaire, C Gally, M Labouesse	01/09/2019
Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level. Journal of cell science	H Lee, SG Eskin, S Ono, C Zhu, LV McIntire	04/02/2019
Real-Time Single-Molecule Kinetic Analyses of AIP1-Enhanced Actin Filament Severing in the Presence of Cofilin. Journal of molecular biology	K Hayakawa, C Sekiguchi, M Sokabe, S Ono, H Tatsumi	18/01/2019
Mutations in Caenorhabditis elegans actin, which are equivalent to human cardiomyopathy mutations, cause abnormal actin aggregation in nematode striated muscle. F1000Research	Y Hayashi, K Ono, S Ono	01/01/2019
Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation. Biochemical and biophysical research communications	S Ono	25/11/2018
Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner. Cytoskeleton (Hoboken, N.J.)	E Watabe, S Ono, H Kuroyanagi	01/10/2018
Tropomyosin isoforms differentially affect muscle contractility in the head and body regions of the nematode Caenorhabditis elegans. Molecular biology of the cell	DE Barnes, E Watabe, K Ono, E Kwak, H Kuroyanagi, S Ono	01/05/2018
Conserved hydrophobic residues in the CARP/β-sheet domain of cyclase-associated protein are involved in actin monomer regulation. Cytoskeleton (Hoboken, N.J.)	S Iwase, S Ono	01/09/2017
A plague of actin disassembly. The Journal of biological chemistry	S Ono	12/05/2017
The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation. The Biochemical journal	S Iwase, S Ono	01/12/2016
Regulation of actin catch-slip bonds with a RhoA-formin module. Scientific reports	CY Lee, J Lou, KK Wen, M McKane, SG Eskin, PA Rubenstein, S Chien, S Ono, C Zhu, LV McIntire	12/10/2016
Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad. Molecular biology of the cell	K Ono, S Ono	01/04/2016
Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion. Cytoskeleton (Hoboken, N.J.)	DE Barnes, H Hwang, K Ono, H Lu, S Ono	01/03/2016
Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans. Scientific reports	H Hwang, DE Barnes, Y Matsunaga, GM Benian, S Ono, H Lu	29/01/2016