Edward Mocarski, PhD
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Research Program
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Phone Number
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Email Address
Biography
Edward S. Mocarski, Jr., PhD, is professor emeritus in the Department of Microbiology and Immunology of Emory University School of Medicine. Prior to joining Emory, Dr. Mocarski was a Professor of Microbiology and Immunology and Associate Dean of Research at Stanford University. Dr. Mocarski is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.
Education
Dr. Mocarski obtained his PhD in Microbiology from the University of Iowa. He then completed a postdoctoral fellowship in Virology at The University of Chicago.
Titles & Roles
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Professor Emeritus, Department of Microbiology and ImmunologyEmory University School of Medicine
Research
Dr. Mocarski’s research over the past decade has focused on the infected cell response to infection, mainly the contribution of regulated cell death pathways to host defense.
Grants
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Grant Number Title 2T32GM095442-11 Critical Care Training Program Title/Journal Authors Publication Date PLoS pathogens
TL Cleverley, S Peddineni, J Guarner, F Cingolani, PK Garcia, H Koehler, ES Mocarski, D Kalman 01/05/2023 Science advances
R Sonowal, AI Swimm, F Cingolani, N Parulekar, TL Cleverley, A Sahoo, A Ranawade, D Chaudhuri, ES Mocarski, H Koehler, K Nitsche, S Mesiano, D Kalman 24/02/2023 p38MAPK guards the integrity of endosomal compartments through regulating necrotic death.
Scientific reports
J Yao, S Atasheva, R Toy, EL Blanchard, PJ Santangelo, K Roy, ES Mocarski, DM Shayakhmetov 29/09/2022 Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis.
Cell host & microbe
H Koehler, S Cotsmire, T Zhang, S Balachandran, JW Upton, J Langland, D Kalman, BL Jacobs, ES Mocarski 11/08/2021 Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.
Journal of immunology (Baltimore, Md. : 1950)
Y Feng, D Livingston-Rosanoff, L Roback, A Sundararajan, SH Speck, ES Mocarski, LP Daley-Bauer 15/10/2018 Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Immunity
P Mandal, Y Feng, JD Lyons, SB Berger, S Otani, A DeLaney, GK Tharp, K Maner-Smith, EM Burd, M Schaeffer, S Hoffman, C Capriotti, L Roback, CB Young, Z Liang, EA Ortlund, NC DiPaolo, S Bosinger, J Bertin, PJ Gough, IE Brodsky, CM Coopersmith, DM Shayakhmetov, ES Mocarski 17/07/2018 Cell host & microbe
S Nogusa, RJ Thapa, CP Dillon, S Liedmann, TH Oguin, JP Ingram, DA Rodriguez, R Kosoff, S Sharma, O Sturm, K Verbist, PJ Gough, J Bertin, BM Hartmann, SC Sealfon, WJ Kaiser, ES Mocarski, CB López, PG Thomas, A Oberst, DR Green, S Balachandran 13/07/2016 T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Nature immunology
BN Martin, C Wang, CJ Zhang, Z Kang, MF Gulen, JA Zepp, J Zhao, G Bian, JS Do, B Min, PG Pavicic, C El-Sanadi, PL Fox, A Akitsu, Y Iwakura, A Sarkar, MD Wewers, WJ Kaiser, ES Mocarski, ME Rothenberg, AG Hise, GR Dubyak, RM Ransohoff, X Li 01/05/2016 Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
The Journal of biological chemistry
C Antonopoulos, HM Russo, C El Sanadi, BN Martin, X Li, WJ Kaiser, ES Mocarski, GR Dubyak 14/08/2015 Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Nature communications
S Kang, T Fernandes-Alnemri, C Rogers, L Mayes, Y Wang, C Dillon, L Roback, W Kaiser, A Oberst, J Sagara, KA Fitzgerald, DR Green, J Zhang, ES Mocarski, ES Alnemri 24/06/2015 Manipulation of apoptosis and necroptosis signaling by herpesviruses.
Medical microbiology and immunology
H Guo, WJ Kaiser, ES Mocarski 01/06/2015 Stanley Plotkin: the bright spark of cytomegalovirus vaccines.
Medical microbiology and immunology
ES Mocarski 01/06/2015 Necroptosis: The Trojan horse in cell autonomous antiviral host defense.
Virology
ES Mocarski, H Guo, WJ Kaiser 01/05/2015 The immunological underpinnings of vaccinations to prevent cytomegalovirus disease.
Cellular & molecular immunology
AL McCormick, ES Mocarski 01/03/2015 The A, B, Cs of herpesvirus capsids.
Viruses
R Tandon, ES Mocarski, JF Conway 26/02/2015 Herpes simplex virus suppresses necroptosis in human cells.
Cell host & microbe
H Guo, S Omoto, PA Harris, JN Finger, J Bertin, PJ Gough, WJ Kaiser, ES Mocarski 11/02/2015 MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a.
Journal of virology
YR Fu, XJ Liu, XJ Li, ZZ Shen, B Yang, CC Wu, JF Li, LF Miao, HQ Ye, GH Qiao, S Rayner, S Chavanas, C Davrinche, WJ Britt, Q Tang, M McVoy, E Mocarski, MH Luo 15/01/2015 TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
eLife
JA Rickard, H Anderton, N Etemadi, U Nachbur, M Darding, N Peltzer, N Lalaoui, KE Lawlor, H Vanyai, C Hall, A Bankovacki, L Gangoda, WW Wong, J Corbin, C Huang, ES Mocarski, JM Murphy, WS Alexander, AK Voss, DL Vaux, WJ Kaiser, H Walczak, J Silke 02/12/2014 RIP3 induces apoptosis independent of pronecrotic kinase activity.
Molecular cell
P Mandal, SB Berger, S Pillay, K Moriwaki, C Huang, H Guo, JD Lich, J Finger, V Kasparcova, B Votta, M Ouellette, BW King, D Wisnoski, AS Lakdawala, MP DeMartino, LN Casillas, PA Haile, CA Sehon, RW Marquis, J Upton, LP Daley-Bauer, L Roback, N Ramia, CM Dovey, JE Carette, FK Chan, J Bertin, PJ Gough, ES Mocarski, WJ Kaiser 20/11/2014 Journal of immunology (Baltimore, Md. : 1950)
S Ganesan, VAK Rathinam, L Bossaller, K Army, WJ Kaiser, ES Mocarski, CP Dillon, DR Green, TN Mayadas, SM Levitz, AG Hise, N Silverman, KA Fitzgerald 01/09/2014 Journal of immunology (Baltimore, Md. : 1950)
SB Berger, V Kasparcova, S Hoffman, B Swift, L Dare, M Schaeffer, C Capriotti, M Cook, J Finger, A Hughes-Earle, PA Harris, WJ Kaiser, ES Mocarski, J Bertin, PJ Gough 15/06/2014 RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Proceedings of the National Academy of Sciences of the United States of America
WJ Kaiser, LP Daley-Bauer, RJ Thapa, P Mandal, SB Berger, C Huang, A Sundararajan, H Guo, L Roback, SH Speck, J Bertin, PJ Gough, S Balachandran, ES Mocarski 27/05/2014 Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Proceedings of the National Academy of Sciences of the United States of America
D Weng, R Marty-Roix, S Ganesan, MK Proulx, GI Vladimer, WJ Kaiser, ES Mocarski, K Pouliot, FK Chan, MA Kelliher, PA Harris, J Bertin, PJ Gough, DM Shayakhmetov, JD Goguen, KA Fitzgerald, N Silverman, E Lien 20/05/2014 Cell host & microbe
LP Daley-Bauer, LJ Roback, GM Wynn, ES Mocarski 12/03/2014 True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity.
Journal of immunology (Baltimore, Md. : 1950)
ES Mocarski, WJ Kaiser, D Livingston-Rosanoff, JW Upton, LP Daley-Bauer 01/03/2014 Journal of virology
S Omoto, ES Mocarski 01/01/2014 Priorities for CMV vaccine development.
Vaccine
PR Krause, SR Bialek, SB Boppana, PD Griffiths, CA Laughlin, P Ljungman, ES Mocarski, RF Pass, JS Read, MR Schleiss, SA Plotkin 17/12/2013 Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.
Cell death and differentiation
AB Long, WJ Kaiser, ES Mocarski, T Caspary 01/11/2013 Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
The Journal of biological chemistry
WJ Kaiser, H Sridharan, C Huang, P Mandal, JW Upton, PJ Gough, CA Sehon, RW Marquis, J Bertin, ES Mocarski 25/10/2013 Cytomegalovirus UL91 is essential for transcription of viral true late (γ2) genes.
Journal of virology
S Omoto, ES Mocarski 01/08/2013 Viral modulation of programmed necrosis.
Current opinion in virology
WJ Kaiser, JW Upton, ES Mocarski 01/06/2013 Virology
LN Crosby, AL McCormick, ES Mocarski 20/02/2013 Virology
AL McCormick, L Roback, G Wynn, ES Mocarski 20/01/2013 Antiviral T cell response triggers cytomegalovirus hepatitis in mice.
Journal of virology
D Livingston-Rosanoff, LP Daley-Bauer, A Garcia, AL McCormick, J Huang, ES Mocarski 01/12/2012 Viral and host control of cytomegalovirus maturation.
Trends in microbiology
R Tandon, ES Mocarski 01/08/2012 Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes.
Immunity
LP Daley-Bauer, GM Wynn, ES Mocarski 27/07/2012 Cell host & microbe
JW Upton, WJ Kaiser, ES Mocarski 15/03/2012 Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways.
Nature reviews. Immunology
ES Mocarski, JW Upton, WJ Kaiser 23/12/2011 Cytomegalovirus UL103 controls virion and dense body egress.
Journal of virology
J Ahlqvist, E Mocarski 01/05/2011 RIP3 mediates the embryonic lethality of caspase-8-deficient mice.
Nature
WJ Kaiser, JW Upton, AB Long, D Livingston-Rosanoff, LP Daley-Bauer, R Hakem, T Caspary, ES Mocarski 17/03/2011 Virus inhibition of RIP3-dependent necrosis.
Cell host & microbe
JW Upton, WJ Kaiser, ES Mocarski 22/04/2010 Human cytomegalovirus exploits ESCRT machinery in the process of virion maturation.
Journal of virology
R Tandon, DP AuCoin, ES Mocarski 01/10/2009 Transfusion
JE Hendrickson, N Saakadze, CM Cadwell, JW Upton, ES Mocarski, CD Hillyer, JC Zimring 01/08/2009 Journal of immunology (Baltimore, Md. : 1950)
WJ Kaiser, JW Upton, ES Mocarski 01/11/2008 Control of cytoplasmic maturation events by cytomegalovirus tegument protein pp150.
Journal of virology
R Tandon, ES Mocarski 01/10/2008 The Journal of biological chemistry
JW Upton, WJ Kaiser, ES Mocarski 20/06/2008 PLoS pathogens
AL McCormick, L Roback, ES Mocarski 09/05/2008