Gregory B. Lesinski, PhD, MPH
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Research Program
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Email Address
Biography
Gregory B. Lesinski, PhD, MPH, is professor and serves as vice chair for basic research in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Lesinski also serves as Winship Cancer Institute's associate director for basic research and shared resources where he provides oversight and direction for the development and growth of Winship's basic scientific activities across the cancer center’s four research programs. Prior to joining Emory, Dr. Lesinski was associate professor in the Department of Internal Medicine, Division of Medical Oncology at The Ohio State University.
Education
Dr. Lesinski received his PhD in Biomedical Sciences from The Medical College of Ohio in Toledo, Ohio. He obtained his MPH in Clinical Investigation from The Ohio State University in Columbus, Ohio. He completed his post-doctoral training at The Ohio State University.
Titles & Roles
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John Kauffman Family Professorship for Pancreatic Cancer ResearchEmory University School of Medicine
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Professor, Department of Hematology and Medical OncologyEmory University School of Medicine
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Associate Director for Basic Research and Shared ResourcesWinship Cancer Institute of Emory University
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Co-Director Translational GI Malignancy ProgramWinship Cancer Institute of Emory University
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Vice Chair for Basic Research, Department of Hematology and Medical OncologyEmory University School of Medicine
Professional Memberships
- American Association for Cancer Research
- Society for Melanoma Research
- Society for Immunotherapy of Cancer
- American Association of Immunologists
Research
Dr. Lesinski's research is focused on gaining a greater understanding of the interactions between the host immune system and tumor cells. The ultimate goal is to use this knowledge to develop novel therapeutic or chemo-preventative approaches to help patients with cancer, and improve upon existing therapies. Of particular interest are modulation of cytokines and downstream signaling pathways to maximize the effect of immune based therapy.
Grants
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Grant Number Title 1R01CA228406-01A1 Targeting immune stroma interactions in pancreatic cancer 5R01CA228406-02 Targeting immune stroma interactions in pancreatic cancer 5R01CA228406-03 Targeting immune stroma interactions in pancreatic cancer 5R01CA228406-04 Targeting immune stroma interactions in pancreatic cancer 5R01CA228406-05 Targeting immune stroma interactions in pancreatic cancer Publications
Dr. Lesinski has published numerous articles in peer-reviewed journals including Journal of Immunology, Journal of the National Cancer Institute, and Journal of Clinical Investigation.
Title/Journal Authors Publication Date Journal of experimental & clinical cancer research : CR
F Yang, C Yuan, F Chen, ZS Qin, NC Schmitt, GB Lesinski, NF Saba, Y Teng 12/03/2024 Research square
Y Shen, E Connolly, M Aiello, C Zhou, P Chappa, H Song, P Tippitak, T Clark, M Cardenas, N Prokhnevska, A Mariniello, MS Pagadala, VR Dhere, S Rafiq, AH Kesarwala, A Orthwein, SN Thomas, MK Khan, J Brandon Dixon, GB Lesinski, MC Lowe, H Kissick, DS Yu, CM Paulos, NC Schmitt, ZS Buchwald 06/03/2024 Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy.
Journal for immunotherapy of cancer
NK Horvat, I Karpovsky, M Phillips, MM Wyatt, MA Hall, CJ Herting, J Hammons, Z Mahdi, RA Moffitt, CM Paulos, GB Lesinski 08/01/2024 Cancer research
GO Rangel Rivera, CJ Dwyer, HM Knochelmann, AS Smith, BA Aksoy, AC Cole, MM Wyatt, S Kumaresan, JE Thaxton, GB Lesinski, CM Paulos 02/01/2024 bioRxiv : the preprint server for biology
MC Wittling, HM Knochelmann, MM Wyatt, GO Rangel Rivera, AC Cole, GB Lesinski, CM Paulos 18/12/2023 Top advances of the year: Pancreatic cancer.
Cancer
EAK Warren, GB Lesinski, SK Maithel 15/12/2023 Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.
Nature
H Fan, S Xia, J Xiang, Y Li, MO Ross, SA Lim, F Yang, J Tu, L Xie, U Dougherty, FQ Zhang, Z Zheng, R Zhang, R Wu, L Dong, R Su, X Chen, T Althaus, PA Riedell, PB Jonker, A Muir, GB Lesinski, S Rafiq, MV Dhodapkar, W Stock, O Odenike, AA Patel, J Opferman, T Tsuji, J Matsuzaki, H Shah, B Faubert, SE Elf, B Layden, BM Bissonnette, YY He, J Kline, H Mao, K Odunsi, X Gao, H Chi, C He, J Chen 01/11/2023 Journal for immunotherapy of cancer
M Akce, B Farran, JM Switchenko, M Rupji, S Kang, L Khalil, A Ruggieri-Joyce, B Olson, WL Shaib, C Wu, OB Alese, M Diab, GB Lesinski, BF El-Rayes 01/10/2023 Impact of nodal status in determining multimodal treatment strategies in non-cardia gastric cancer.
Journal of surgical oncology
PS Ajay, CP Sok, S Goyal, JM Switchenko, FB Maegawa, TW Gillespie, CM Paulos, GB Lesinski, DA Kooby, TJ Kennedy, MM Shah 01/08/2023 Journal of translational medicine
PA Ascierto, A Avallone, C Bifulco, S Bracarda, JD Brody, LA Emens, RL Ferris, SC Formenti, O Hamid, DB Johnson, T Kirchhoff, CA Klebanoff, GB Lesinski, A Monette, B Neyns, K Odunsi, CM Paulos, DJ Powell, K Rezvani, BH Segal, N Singh, RJ Sullivan, BA Fox, I Puzanov 20/07/2023 Molecular therapy : the journal of the American Society of Gene Therapy
MM Wyatt, LW Huff, MH Nelson, LR Neal, AR Medvec, GO Rangel Rivera, AS Smith, AM Rivera Reyes, HM Knochelmann, JL Riley, GB Lesinski, CM Paulos 05/07/2023 Foods (Basel, Switzerland)
JH Ahn-Jarvis, D Sosh, E Lombardo, GB Lesinski, DL Conwell, PA Hart, Y Vodovotz 24/04/2023 Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell- and CXCR3-dependent manner.
JCI insight
MB Ware, M Phillips, C McQuinn, MY Zaidi, HM Knochelmann, E Greene, B Robinson, CJ Herting, TA Mace, Z Chen, C Zhang, MR Farren, AN Ruggieri, JS Bowers, R Shakya, AB Farris, G Young, WE Carson, B El-Rayes, CM Paulos, GB Lesinski 24/04/2023 bioRxiv : the preprint server for biology
GO Rangel Rivera, CJ Dwyer, HM Knochelmann, AS Smith, A Aksoy, AC Cole, MM Wyatt, JE Thaxton, GB Lesinski, CM Paulos 10/03/2023 Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models.
Journal for immunotherapy of cancer
V Kansal, AJ Burnham, BLC Kinney, NF Saba, C Paulos, GB Lesinski, ZS Buchwald, NC Schmitt 01/01/2023 Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
S Han, DL Conwell, L Li, A Cervantes, PA Hart, Z Cruz-Monserrate, W Hao, GB Lesinski, T Mace, TM Palermo, JL Saloman, D Yadav, SS Vege, M Topazian 01/01/2023 The Journal of clinical investigation
NK Horvat, GB Lesinski 01/12/2022 STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.
Life science alliance
JE Lefler, CB MarElia-Bennett, KA Thies, BE Hildreth, SM Sharma, JR Pitarresi, L Han, C Everett, C Koivisto, MC Cuitino, CD Timmers, E O'Quinn, M Parrish, MJ Romeo, AJ Linke, GA Hobbs, G Leone, DC Guttridge, TA Zimmers, GB Lesinski, MC Ostrowski 01/11/2022 Nature communications
S Ravindranathan, T Passang, JM Li, S Wang, R Dhamsania, MB Ware, MY Zaidi, J Zhu, M Cardenas, Y Liu, S Gumber, B Robinson, A Sen-Majumdar, H Zhang, S Chandrakasan, H Kissick, AB Frey, SN Thomas, BF El-Rayes, GB Lesinski, EK Waller 27/10/2022 Clinical cancer research : an official journal of the American Association for Cancer Research
AN Ruggieri, M Yarchoan, S Goyal, Y Liu, E Sharon, HX Chen, BM Olson, CM Paulos, BF El-Rayes, SK Maithel, NS Azad, GB Lesinski 03/10/2022 Gut
LI Ruffolo, KM Jackson, PC Kuhlers, BS Dale, NM Figueroa Guilliani, NA Ullman, PR Burchard, SS Qin, PG Juviler, JM Keilson, AB Morrison, M Georger, R Jewell, LM Calvi, TM Nywening, MR O'Dell, AF Hezel, L De Las Casas, GB Lesinski, JJ Yeh, R Hernandez-Alejandro, BA Belt, DC Linehan 01/07/2022 JCO precision oncology
K Mody, P Jain, SM El-Refai, NS Azad, DJ Zabransky, M Baretti, RT Shroff, RK Kelley, AB El-Khouiery, AJ Hockenberry, D Lau, GB Lesinski, M Yarchoan 01/06/2022 Virology journal
S Tang, L Shi, BT Luker, C Mickler, B Suresh, GB Lesinski, D Fan, Y Liu, M Luo 23/02/2022 The Journal of clinical investigation
M Yarchoan, L Cope, AN Ruggieri, RA Anders, AM Noonan, LW Goff, L Goyal, J Lacy, D Li, AK Patel, AR He, GK Abou-Alfa, K Spencer, EJ Kim, SL Davis, AJ McRee, PR Kunk, S Goyal, Y Liu, L Dennison, S Xavier, AA Mohan, Q Zhu, A Wang-Gillam, A Poklepovic, HX Chen, E Sharon, GB Lesinski, NS Azad 15/12/2021 Cancer immunology, immunotherapy : CII
CJ Herting, MR Farren, Y Tong, Z Liu, B O'Neil, T Bekaii-Saab, A Noonan, C McQuinn, TA Mace, W Shaib, C Wu, BF El-Rayes, S Shahda, GB Lesinski 01/11/2021 Cancer immunology research
L Dennison, A Ruggieri, A Mohan, J Leatherman, K Cruz, S Woolman, N Azad, GB Lesinski, EM Jaffee, M Yarchoan 01/10/2021 Cancer metastasis reviews
CJ Herting, I Karpovsky, GB Lesinski 01/09/2021 Annals of surgical oncology
AJ Rossi, TM Khan, H Hong, GB Lesinski, C Wu, JM Hernandez 01/08/2021 The oncologist
IH Sahin, S Goyal, Y Pumpalova, MB Sonbol, S Das, S Haraldsdottir, D Ahn, KK Ciombor, Z Chen, A Draper, J Berlin, T Bekaii-Saab, GB Lesinski, BF El-Rayes, C Wu 01/08/2021 Braking the cell's cycle and invigorating T-cell immunity against pancreatic cancer.
Gut
GB Lesinski 01/01/2021 Molecular cancer therapeutics
Y Zhang, MB Ware, MY Zaidi, AN Ruggieri, BM Olson, H Komar, MR Farren, GP Nagaraju, C Zhang, Z Chen, JM Sarmiento, R Ahmed, SK Maithel, BF El-Rayes, GB Lesinski 01/01/2021 Pancreas
Z Cruz-Monserrate, K Gumpper, S Kaul, N Badi, S Terhorst, K Dubay, GB Lesinski, W Fisher, A McElhany, LF Lara, S Krishna, T Mace, N Higuita-Castro, L Ortega-Pineda, MA Freitas, A Hinton, D Yadav, PA Hart, SJ Pandol, S Ahmed, B Fatou, H Steen, DL Conwell 01/01/2021 iScience
KG Birmingham, MJ O'Melia, S Bordy, D Reyes Aguilar, B El-Reyas, G Lesinski, SN Thomas 20/11/2020 British journal of cancer
MB Ware, MY Zaidi, J Yang, MK Turgeon, A Krasinskas, TA Mace, K Keenan, MR Farren, AN Ruggieri, Y Li, C Zhang, Z Chen, GS Young, O Elnaggar, Z Che, SK Maithel, T Bekaii-Saab, B El-Rayes, GB Lesinski 01/10/2020 IL6 Fuels Durable Memory for Th17 Cell-Mediated Responses to Tumors.
Cancer research
HM Knochelmann, CJ Dwyer, AS Smith, JS Bowers, MM Wyatt, MH Nelson, GO Rangel Rivera, JD Horton, C Krieg, K Armeson, GB Lesinski, MP Rubinstein, Z Li, CM Paulos 15/09/2020 Mirage or long-awaited oasis: reinvigorating T-cell responses in pancreatic cancer.
Journal for immunotherapy of cancer
MB Ware, BF El-Rayes, GB Lesinski 01/08/2020 Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer.
Cancer
GP Nagaraju, B Farran, M Farren, G Chalikonda, C Wu, GB Lesinski, BF El-Rayes 15/07/2020 Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency.
Biomacromolecules
LA Perdue, P Do, C David, A Chyong, AV Kellner, A Ruggieri, HR Kim, K Salaita, GB Lesinski, CC Porter, EC Dreaden 13/07/2020 Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
J Ahn-Jarvis, E Lombardo, Z Cruz-Monserrate, N Badi, O Crowe, S Kaul, H Komar, SG Krishna, GB Lesinski, TA Mace, ML Ramsey, K Roberts, K Stinehart, M Traczek, DL Conwell, Y Vodovotz, PA Hart 01/07/2020 JCO oncology practice
IH Sahin, SR Kane, E Brutcher, J Guadagno, KE Smith, C Wu, GB Lesinski, CJ Gunthel, BF El-Rayes 01/06/2020 JCI insight
MR Farren, L Sayegh, MB Ware, HR Chen, J Gong, Y Liang, A Krasinskas, SK Maithel, M Zaidi, JM Sarmiento, D Kooby, P Patel, B El-Rayes, W Shaib, GB Lesinski 16/01/2020 Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression.
Molecular cancer research : MCR
S Chandrasekaran, M Sasaki, CD Scharer, HT Kissick, DG Patterson, KR Magliocca, JT Seykora, B Sapkota, DA Gutman, LA Cooper, GB Lesinski, EK Waller, SN Thomas, SV Kotenko, JM Boss, CS Moreno, RA Swerlick, BP Pollack 01/12/2019 British journal of cancer
IH Sahin, M Akce, O Alese, W Shaib, GB Lesinski, B El-Rayes, C Wu 01/11/2019 Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer.
International journal of cancer
GP Nagaraju, KM Zakka, JC Landry, WL Shaib, GB Lesinski, BF El-Rayes 15/09/2019 Head and neck pathology
GB Lesinski, S Nannapaneni, CC Griffith, M Patel, W Chen, Z Chen, R Ahmed, A Wieland, DM Shin, ZG Chen, NF Saba 01/09/2019 Oncogene
L Deng, G Qian, S Zhang, H Zheng, S Fan, GB Lesinski, TK Owonikoko, SS Ramalingam, SY Sun 01/08/2019 Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function.
Scientific reports
TA Mace, MB Ware, SA King, S Loftus, MR Farren, E McMichael, S Scoville, C Geraghty, G Young, WE Carson, SK Clinton, GB Lesinski 25/03/2019 Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ML Ramsey, E Talbert, D Ahn, T Bekaii-Saab, N Badi, PM Bloomston, DL Conwell, Z Cruz-Monserrate, M Dillhoff, MR Farren, A Hinton, SG Krishna, GB Lesinski, T Mace, A Manilchuk, A Noonan, TM Pawlik, PV Rajasekera, C Schmidt, D Guttridge, PA Hart 01/01/2019 MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity.
PloS one
M Yarchoan, AA Mohan, L Dennison, T Vithayathil, A Ruggieri, GB Lesinski, TD Armstrong, NS Azad, EM Jaffee 01/01/2019 Stressing for sugar: a new role of serotonin for glycolysis in pancreatic cancer cells.
Annals of pancreatic cancer
GB Lesinski 01/10/2018 Life science alliance
JR Pitarresi, X Liu, A Avendano, KA Thies, GM Sizemore, AM Hammer, BE Hildreth, DJ Wang, SA Steck, S Donohue, MC Cuitiño, RD Kladney, TA Mace, JJ Chang, CS Ennis, H Li, RH Reeves, S Blackshaw, J Zhang, L Yu, SA Fernandez, WL Frankel, M Bloomston, TJ Rosol, GB Lesinski, SF Konieczny, DC Guttridge, AK Rustgi, G Leone, JW Song, J Wu, MC Ostrowski 01/10/2018 Journal of cachexia, sarcopenia and muscle
EE Talbert, HL Lewis, MR Farren, ML Ramsey, JM Chakedis, P Rajasekera, E Haverick, A Sarna, M Bloomston, TM Pawlik, TA Zimmers, GB Lesinski, PA Hart, ME Dillhoff, CR Schmidt, DC Guttridge 01/04/2018 Gut
TA Mace, R Shakya, JR Pitarresi, B Swanson, CW McQuinn, S Loftus, E Nordquist, Z Cruz-Monserrate, L Yu, G Young, X Zhong, TA Zimmers, MC Ostrowski, T Ludwig, M Bloomston, T Bekaii-Saab, GB Lesinski 01/02/2018 The Potential of CAR T Cell Therapy in Pancreatic Cancer.
Frontiers in immunology
M Akce, MY Zaidi, EK Waller, BF El-Rayes, GB Lesinski 01/01/2018 Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.
Journal of clinical pharmacology
AE Kersh, S Ng, YM Chang, M Sasaki, SN Thomas, HT Kissick, GB Lesinski, RR Kudchadkar, EK Waller, BP Pollack 01/01/2018 Pancreas
WE Fisher, Z Cruz-Monserrate, AL McElhany, GB Lesinski, PA Hart, R Ghosh, G Van Buren, DS Fishman, JAS Rinaudo, J Serrano, S Srivastava, T Mace, M Topazian, Z Feng, D Yadav, SJ Pandol, SJ Hughes, RY Liu, E Lu, R Orr, DC Whitcomb, AS Abouhamze, H Steen, ZM Sellers, DM Troendle, A Uc, ME Lowe, DL Conwell 01/01/2018 Cancer
A Belalcazar, WL Shaib, MR Farren, C Zhang, Z Chen, L Yang, GB Lesinski, BF El-Rayes, GP Nagaraju 15/12/2017 Local and Systemic Expression of Immunomodulatory Factors in Chronic Pancreatitis.
Pancreas
HM Komar, PA Hart, Z Cruz-Monserrate, DL Conwell, GB Lesinski 01/09/2017 Cancer letters
GP Nagaraju, C Wu, N Merchant, Z Chen, GB Lesinski, BF El-Rayes 28/08/2017 Cancer research
SB Gomez-Chou, AK Swidnicka-Siergiejko, N Badi, M Chavez-Tomar, GB Lesinski, T Bekaii-Saab, MR Farren, TA Mace, C Schmidt, Y Liu, D Deng, RF Hwang, L Zhou, T Moore, D Chatterjee, H Wang, X Leng, RB Arlinghaus, CD Logsdon, Z Cruz-Monserrate 15/05/2017 Scientific reports
HM Komar, G Serpa, C Kerscher, E Schwoegl, TA Mace, M Jin, MC Yang, CS Chen, M Bloomston, MC Ostrowski, PA Hart, DL Conwell, GB Lesinski 11/05/2017 Mathematical model of chronic pancreatitis.
Proceedings of the National Academy of Sciences of the United States of America
W Hao, HM Komar, PA Hart, DL Conwell, GB Lesinski, A Friedman 09/05/2017 Signaling pathways as therapeutic targets in biliary tract cancer.
Expert opinion on therapeutic targets
J Yang, MR Farren, D Ahn, T Bekaii-Saab, GB Lesinski 01/05/2017 Clinical and translational gastroenterology
JP Shapiro, HM Komar, B Hancioglu, L Yu, M Jin, Y Ogata, PA Hart, Z Cruz-Monserrate, GB Lesinski, DL Conwell 13/04/2017 Molecular cancer therapeutics
MR Farren, RC Hennessey, R Shakya, O Elnaggar, G Young, K Kendra, Y Landesman, S Elloul, M Crochiere, B Klebanov, T Kashyap, CE Burd, GB Lesinski 01/03/2017 Molecular cancer therapeutics
EE Talbert, J Yang, TA Mace, MR Farren, AB Farris, GS Young, O Elnaggar, Z Che, CD Timmers, P Rajasekera, JM Maskarinec, M Bloomston, T Bekaii-Saab, DC Guttridge, GB Lesinski 01/02/2017 Cancer immunology, immunotherapy : CII
MC Duggan, C Jochems, RN Donahue, J Richards, V Karpa, E Foust, B Paul, T Brooks, S Tridandapani, T Olencki, X Pan, GB Lesinski, J Schlom, WE Carson Iii 01/11/2016