Sandeep Kumar, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-712-8951
Email Address

sandeepkumar@emory.edu

Biography

Sandeep Kumar, PhD, is an assistant professor in the Walter H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

Dr. Kumar is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute.

Education

Dr. Kumar received his MS in biotechnology at Kurukshetra University in India. He earned his PhD in the same subject at University of Pune. Dr. Kumar performed two post doctorates, first at Texas A&M in molecular cardiology, then later at Emory University in biomedical engineering and cardiology.

Titles & Roles

Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering

Georgia Institute of Technology and Emory University

Research

Dr. Kumar's research is focused on studying the role of microRNAs and long non-coding RNAs in endothelial biology and atherosclerosis.

Title/Journal	Authors	Publication Date
HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells. Circulation	IA Tamargo, KI Baek, C Xu, DW Kang, Y Kim, A Andueza, D Williams, C Demos, N Villa-Roel, S Kumar, C Park, R Choi, J Johnson, S Chang, P Kim, S Tan, K Jeong, S Tsuji, H Jo	09/04/2024
EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening. Journal of experimental & clinical cancer research : CR	A Cappelletto, E Alfì, N Volf, TVA Vu, F Bortolotti, G Ciucci, S Vodret, M Fantuz, M Perin, A Colliva, G Rozzi, M Rossi, G Ruozi, L Zentilin, R Vuerich, D Borin, R Lapasin, S Piazza, M Chiesa, D Lorizio, L Triboli, S Kumar, G Morello, C Tripodo, M Pinamonti, GM Piperno, F Benvenuti, A Rustighi, H Jo, S Piccolo, G Del Sal, A Carrer, M Giacca, S Zacchigna	10/01/2024
Cardiac Radiomics Are Associated With Dyspnea. JACC. Advances	S Kumar, S Al-Kindi, MHE Makhlouf, S Sivakumar, A Midya, G Modanwal, V Rajagopalan, A Tandon, S Rajagopalan, A Madabhushi	01/01/2024
Myeloid CCN3 protects against aortic valve calcification. Cell communication and signaling : CCS	P Tu, Q Xu, X Zhou, N Villa-Roel, S Kumar, N Dong, H Jo, C Ou, Z Lin	20/01/2023
Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation. Cardiovascular research	EV Dolmatova, SJ Forrester, K Wang, Z Ou, HC Williams, G Joseph, S Kumar, A Valdivia, AP Kowalczyk, H Qu, H Jo, B Lassègue, MS Hernandes, KK Griendling	24/08/2022
Perspectives on the Risk-Stratified Treatment of Multiple Myeloma. Blood cancer discovery	FE Davies, C Pawlyn, SZ Usmani, JF San-Miguel, H Einsele, EM Boyle, J Corre, D Auclair, HJ Cho, S Lonial, P Sonneveld, AK Stewart, PL Bergsagel, MF Kaiser, K Weisel, JJ Keats, JR Mikhael, KE Morgan, IM Ghobrial, RZ Orlowski, CO Landgren, F Gay, J Caers, WJ Chng, A Chari, BA Walker, SK Kumar, LJ Costa, KC Anderson, GJ Morgan	06/07/2022
Ventricular reshaping with a beating heart implant improves pump function in experimental heart failure. The Journal of thoracic and cardiovascular surgery	D Onohara, DM Corporan, T Kono, S Kumar, RA Guyton, M Padala	01/05/2022
Hypoxia inducible factor 1α inhibitor PX-478 reduces atherosclerosis in mice. Atherosclerosis	N Villa-Roel, K Ryu, L Gu, J Fernandez Esmerats, DW Kang, S Kumar, H Jo	01/03/2022
Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo. Science advances	CF Yeh, SH Cheng, YS Lin, TP Shentu, RT Huang, J Zhu, YT Chen, S Kumar, MS Lin, HL Kao, PH Huang, E Roselló-Sastre, F Garcia, H Jo, Y Fang, KC Yang	21/01/2022
Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis. eLife	D Williams, M Mahmoud, R Liu, A Andueza, S Kumar, DW Kang, J Zhang, I Tamargo, N Villa-Roel, KI Baek, H Lee, Y An, L Zhang, EW Tate, P Bagchi, J Pohl, LO Mosnier, EP Diamandis, K Mihara, MD Hollenberg, Z Dai, H Jo	11/01/2022
Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells. Frontiers in cardiovascular medicine	C Demos, J Johnson, A Andueza, C Park, Y Kim, N Villa-Roel, DW Kang, S Kumar, H Jo	01/01/2022
Aging-regulated TUG1 is dispensable for endothelial cell function. PloS one	AT Gimbel, S Koziarek, K Theodorou, JF Schulz, L Stanicek, V Kremer, T Ali, S Günther, S Kumar, H Jo, N Hübner, L Maegdefessel, S Dimmeler, S van Heesch, RA Boon	01/01/2022
Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-cell Multi-omics Experiments. Journal of visualized experiments : JoVE	S Kumar, A Andueza, J Kim, DW Kang, H Jo	04/10/2021
Very late vasomotor responses and gene expression with bioresorbable scaffolds and metallic drug-eluting stents. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions	JS Koh, BD Gogas, S Kumar, JJ Benham, S Sur, N Spilias, A Kumar, DP Giddens, R Rapoza, DJ Kereiakes, G Stone, H Jo, H Samady	01/10/2021
Delivery of Anti-microRNA-712 to Inflamed Endothelial Cells Using Poly(β-amino ester) Nanoparticles Conjugated with VCAM-1 Targeting Peptide. Advanced healthcare materials	P Dosta, I Tamargo, V Ramos, S Kumar, DW Kang, S Borrós, H Jo	01/08/2021
Is Endothelial Dysfunction a Therapeutic Target for Peripheral Artery Disease?: PRDM16 is going out on a limb. Circulation research	S Kumar, A Andueza, H Jo	25/06/2021
Hemodynamic and transcriptomic studies suggest early left ventricular dysfunction in a preclinical model of severe mitral regurgitation. The Journal of thoracic and cardiovascular surgery	D Corporan, D Onohara, A Amedi, M Saadeh, RA Guyton, S Kumar, M Padala	01/03/2021
Delivery of siRNA to Endothelial Cells In Vivo Using Lysine/Histidine Oligopeptide-Modified Poly(β-amino ester) Nanoparticles. Cardiovascular engineering and technology	P Dosta, C Demos, V Ramos, DW Kang, S Kumar, H Jo, S Borrós	01/02/2021
Atorvastatin and blood flow regulate expression of distinctive sets of genes in mouse carotid artery endothelium. Current topics in membranes	S Kumar, S Sur, J Perez, C Demos, DW Kang, CW Kim, S Hu, K Xu, J Yang, H Jo	01/01/2021
SWI/SNF (BAF) complexes: From framework to a functional role in endothelial mechanotransduction. Current topics in membranes	S Kumar	01/01/2021
Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting. PloS one	B Lassègue, S Kumar, R Mandavilli, K Wang, M Tsai, DW Kang, C Demos, MS Hernandes, A San Martín, WR Taylor, H Jo, KK Griendling	01/01/2021
Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study. Cell reports	A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, H Jo	15/12/2020
The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America	SF Glaser, AW Heumüller, L Tombor, P Hofmann, M Muhly-Reinholz, A Fischer, S Günther, KE Kokot, D Hassel, S Kumar, H Jo, RA Boon, W Abplanalp, D John, JN Boeckel, S Dimmeler	25/02/2020
The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. European heart journal	S Xu, Y Xu, P Liu, S Zhang, H Liu, S Slavin, S Kumar, M Koroleva, J Luo, X Wu, A Rahman, J Pelisek, H Jo, S Si, CL Miller, ZG Jin	01/08/2019
Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells. Arteriosclerosis, thrombosis, and vascular biology	J Fernandez Esmerats, N Villa-Roel, S Kumar, L Gu, MT Salim, M Ohh, WR Taylor, RM Nerem, AP Yoganathan, H Jo	01/03/2019
ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. Laboratory investigation; a journal of technical methods and pathology	Y Wang, HY Sun, S Kumar, MDM Puerta, H Jo, A Rezvan	01/03/2019
Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis. Vascular pharmacology	S Kumar, D Williams, S Sur, JY Wang, H Jo	01/03/2019
Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm. Circulation research	S Kumar, RA Boon, L Maegdefessel, S Dimmeler, H Jo	15/02/2019
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nature communications	J Hitzel, E Lee, Y Zhang, SI Bibli, X Li, S Zukunft, B Pflüger, J Hu, C Schürmann, AE Vasconez, JA Oo, A Kratzer, S Kumar, F Rezende, I Josipovic, D Thomas, H Giral, Y Schreiber, G Geisslinger, C Fork, X Yang, F Sigala, CE Romanoski, J Kroll, H Jo, U Landmesser, AJ Lusis, D Namgaladze, I Fleming, MS Leisegang, J Zhu, RP Brandes	12/06/2018
Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3. Cardiovascular engineering and technology	JM Heath, J Fernandez Esmerats, L Khambouneheuang, S Kumar, R Simmons, H Jo	01/06/2018
3D Imaging and Quantitative Analysis of Vascular Networks: A Comparison of Ultramicroscopy and Micro-Computed Tomography. Theranostics	J Epah, K Pálfi, FL Dienst, PF Malacarne, R Bremer, M Salamon, S Kumar, H Jo, C Schürmann, RP Brandes	01/01/2018
Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1. Circulation	CW Kim, A Pokutta-Paskaleva, S Kumar, LH Timmins, AD Morris, DW Kang, S Dalal, T Chadid, KM Kuo, J Raykin, H Li, H Yanagisawa, RL Gleason, H Jo, LP Brewster	26/09/2017
Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation. Laboratory investigation; a journal of technical methods and pathology	S Kumar, DW Kang, A Rezvan, H Jo	01/08/2017