Baek Kim, PhD, MS
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Research Program
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Phone Number
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Email Address
Biography
Baek Kim, PhD, MS, is a professor in the Department of Pediatrics at Emory University School of Medicine. Dr. Kim serves as director of the Children's Center for Drug Discovery.
Dr. Kim is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. He is also a member of the Microbiology and Molecular Genetics Graduate Program and Molecular and Systems Pharmacology Graduate Program in the Graduate Division of Biological and Biomedical Sciences at Laney Graduate School of Emory University.
Education
Dr. Kim earned his PhD in biochemistry from University of Arizona in Tucson, Arizona. He obtained a Master of Science in biochemistry from Yon-Sei University in Seoul, South Korea. He completed his postdoctoral training at University of Washington in Seattle, Washington.
Titles & Roles
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Professor, Department of PediatricsEmory University School of Medicine
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Director, Center for Drug DiscoveryChildren's Healthcare of Atlanta and Emory University
Research
Dr. Kim's current research focuses are: 1) HIV-1 replication, mutagenesis, and evolution, 2) establishment of longliving HIV-1 myeloid reservoirs, 3) role of SAMHD1 in HIV biology. He is trained in the research field of DNA-protein interactions, particularly with transcriptional repressors and DNA polymerases involved in DNA repair and DNA replication.
Grants
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Grant Number Title 1R01AI162633-01 SAMHD1 mediated dNTP regulation and HIV in myeloid cells 1R01CA254403-01 Elucidating SAMHD1 in DNA Double-Strand Break Repair 2R01AI136581-06A1 Lentivirus Replication Strategy and Pathogenesis 2R01AI141327-06A1 Structural and Chemical Analysis of Highly Potent ALLINI Platform 3R01CA254403-04S1 Elucidating SAMHD1 in DNA Double-Strand Break Repair (Supplement) 3R01CA254403-04S2 Elucidating SAMHD1 in DNA Double-Strand Break Repair (Supplement) 5R01AI136581-07 Lentivirus Replication Strategy and Pathogenesis 5R01AI162633-02 SAMHD1 mediated dNTP regulation and HIV in myeloid cells 5R01AI162633-03 SAMHD1 mediated dNTP regulation and HIV in myeloid cells 5R01AI162633-04 SAMHD1 mediated dNTP regulation and HIV in myeloid cells 5R01CA254403-02 Elucidating SAMHD1 in DNA Double-Strand Break Repair 5R01CA254403-03 Elucidating SAMHD1 in DNA Double-Strand Break Repair 5R01CA254403-04 Elucidating SAMHD1 in DNA Double-Strand Break Repair Title/Journal Authors Publication Date Blood
MH Abdelrazak Morsy, I Lilienthal, M Lord, M Merrien, AM Wasik, M Sureda-Gómez, V Amador, HJ Johansson, J Lehtiö, B Garcia-Torre, JI Martin-Subero, N Tsesmetzis, S Tao, RF Schinazi, B Kim, AL Sorteberg, M Wickström, D Sheppard, GZ Rassidakis, IA Taylor, B Christensson, E Campo, N Herold, B Sander 09/05/2024 Blood
A Sobh, E Encinas, AM Patel, G Surapaneni, E Bonilla, CL Kaestner, J Poullard, M Clerio, K Vasan, T Freeman, D Lv, D Dupéré-Richer, A Riva, BG Barwick, D Zhou, LH Boise, CS Mitsiades, B Kim, RL Bennett, NS Chandel, JD Licht 10/04/2024 NAR cancer
W Daddacha, D Monroe, AJ Schlafstein, AE Withers, EB Thompson, D Danelia, NC Luong, F Sesay, SK Rath, ER Usoro, ME Essien, AT Jung, JG Jiang, J Hu, B Mahboubi, A Williams, JE Steinbeck, X Yang, ZS Buchwald, WS Dynan, JM Switchenko, B Kim, MK Khan, DL Jaye, DS Yu 01/03/2024 Nucleic acids research
P Xu, T Yang, DL Kundnani, M Sun, S Marsili, AL Gombolay, Y Jeon, G Newnam, S Balachander, V Bazzani, U Baccarani, VS Park, S Tao, A Lori, RF Schinazi, B Kim, ZF Pursell, G Tell, C Vascotto, F Storici 09/02/2024 bioRxiv : the preprint server for biology
T Dinh, Z Tber, JS Rey, S Mengshetti, AS Annamalai, R Haney, L Briganti, F Amblard, JR Fuchs, P Cherepanov, K Kim, RF Schinazi, JR Perilla, B Kim, M Kvaratskhelia 26/01/2024 Molecular therapy : the journal of the American Society of Gene Therapy
E Valeri, G Unali, F Piras, M Abou-Alezz, G Pais, F Benedicenti, MR Lidonnici, I Cuccovillo, I Castiglioni, S Arévalo, G Spinozzi, I Merelli, R Behrendt, A Oo, B Kim, NR Landau, G Ferrari, E Montini, A Kajaste-Rudnitski 03/01/2024 mBio
M Schüssler, K Schott, NV Fuchs, A Oo, M Zahadi, P Rauch, B Kim, R König 31/10/2023 The Journal of biological chemistry
T Maehigashi, C Lim, LR Wade, NE Bowen, KM Knecht, NN Alvarez, WG Kelly, RF Schinazi, DH Kim, Y Xiong, B Kim 01/09/2023 bioRxiv : the preprint server for biology
M Schüssler, K Schott, NV Fuchs, A Oo, M Zahadi, P Rauch, B Kim, R König 25/08/2023 The Journal of biological chemistry
NE Bowen, S Tao, YJ Cho, RF Schinazi, B Kim 01/08/2023 Nature communications
D Menolfi, BJ Lee, H Zhang, W Jiang, NE Bowen, Y Wang, J Zhao, A Holmes, S Gershik, R Rabadan, B Kim, S Zha 19/06/2023 Research square
CB Prasad, A Oo, Z Qiu, N Li, D Singh, X Xin, YJ Cho, Z Li, X Zhang, C Yan, Q Zheng, J Shao, QE Wang, B Kim, J Zhang 02/05/2023 The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
mBio
MR Singer, T Dinh, L Levintov, AS Annamalai, JS Rey, L Briganti, NJ Cook, VE Pye, IA Taylor, K Kim, AN Engelman, B Kim, JR Perilla, M Kvaratskhelia, P Cherepanov 28/02/2023 Journal of internal medicine
M Jädersten, I Lilienthal, N Tsesmetzis, M Lourda, S Bengtzén, A Bohlin, C Arnroth, T Erkers, B Seashore-Ludlow, G Giraud, GS Barkhordar, S Tao, L Fogelstrand, L Saft, P Östling, RF Schinazi, B Kim, T Schaller, G Juliusson, S Deneberg, S Lehmann, GZ Rassidakis, M Höglund, JI Henter, N Herold 01/12/2022 Nature communications
P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu 07/11/2022 Viruses
NE Bowen, A Oo, B Kim 26/07/2022 MESH1 knockdown triggers proliferation arrest through TAZ repression.
Cell death & disease
T Sun, CC Ding, Y Zhang, Y Zhang, CC Lin, J Wu, Y Setayeshpour, S Coggins, C Shepard, E Macias, B Kim, P Zhou, R Gordân, JT Chi 10/03/2022 The Journal of biological chemistry
A Oo, K Zandi, C Shepard, LC Bassit, K Musall, SL Goh, YJ Cho, DH Kim, RF Schinazi, B Kim 01/03/2022 Molecules (Basel, Switzerland)
A Manchoju, R Zelli, G Wang, C Eymard, A Oo, M Nemer, M Prévost, B Kim, Y Guindon 17/01/2022 SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950)
B Barrett, DH Nguyen, J Xu, K Guo, S Shetty, ST Jones, KL Mickens, C Shepard, A Roers, R Behrendt, L Wu, B Kim, ML Santiago 15/01/2022 The Journal of biological chemistry
NE Bowen, J Temple, C Shepard, A Oo, F Arizaga, P Kapoor-Vazirani, M Persaud, CH Yu, DH Kim, RF Schinazi, DN Ivanov, F Diaz-Griffero, DS Yu, Y Xiong, B Kim 01/10/2021 Distinct Antiretroviral Mechanisms Elicited by a Viral Mutagen.
Journal of molecular biology
M Roth, YZ McDaniel, MB Daly, N Talledge, WM Greggs, SE Patterson, B Kim, LM Mansky 03/09/2021 Cancers
C Bothou, A Sharma, A Oo, B Kim, P Perge, P Igaz, CL Ronchi, I Shapiro, C Hantel 20/08/2021 SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.
Nature communications
C Martinat, A Cormier, J Tobaly-Tapiero, N Palmic, N Casartelli, B Mahboubi, SA Coggins, J Buchrieser, M Persaud, F Diaz-Griffero, L Espert, G Bossis, P Lesage, O Schwartz, B Kim, F Margottin-Goguet, A Saïb, A Zamborlini 28/07/2021 PLoS pathogens
T Maehigashi, S Ahn, UI Kim, J Lindenberger, A Oo, PC Koneru, B Mahboubi, AN Engelman, M Kvaratskhelia, K Kim, B Kim 01/07/2021 Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
Microorganisms
K Zandi, K Musall, A Oo, D Cao, B Liang, P Hassandarvish, S Lan, RL Slack, KA Kirby, L Bassit, F Amblard, B Kim, S AbuBakar, SG Sarafianos, RF Schinazi 22/04/2021 Scientific reports
ZP Lin, NN Al Zouabi, ML Xu, NE Bowen, TL Wu, ES Lavi, PH Huang, YL Zhu, B Kim, ES Ratner 13/04/2021 Nature communications
CH Yu, A Bhattacharya, M Persaud, AB Taylor, Z Wang, A Bulnes-Ramos, J Xu, A Selyutina, A Martinez-Lopez, K Cano, B Demeler, B Kim, SC Hardies, F Diaz-Griffero, DN Ivanov 02/02/2021 iScience
WMM El-Sayed, AL Gombolay, P Xu, T Yang, Y Jeon, S Balachander, G Newnam, S Tao, NE Bowen, T Brůna, M Borodovsky, RF Schinazi, B Kim, Y Chen, F Storici 22/01/2021 Current research in pharmacology and drug discovery
S Tao, K Zandi, L Bassit, YT Ong, K Verma, P Liu, JA Downs-Bowen, T McBrayer, JC LeCher, JJ Kohler, PR Tedbury, B Kim, F Amblard, SG Sarafianos, RF Schinazi 01/01/2021 Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma.
Frontiers in oncology
D Ravi, A Beheshti, N Abermil, F Lansigan, W Kinlaw, NR Matthan, M Mokhtar, FC Passero, P Puliti, KA David, GG Dolnikowski, X Su, Y Chen, M Bijan, RR Varshney, B Kim, SS Dave, MC Rudolph, AM Evens 01/01/2021 Repurposing Nucleoside Analogs for Human Coronaviruses.
Antimicrobial agents and chemotherapy
K Zandi, F Amblard, K Musall, J Downs-Bowen, R Kleinbard, A Oo, D Cao, B Liang, OO Russell, T McBrayer, L Bassit, B Kim, RF Schinazi 16/12/2020 The Journal of biological chemistry
SA Coggins, DH Kim, RF Schinazi, RC Desrosier, B Kim 11/12/2020 Viruses
A Cox, J Schmierer, J D'Angelo, A Smith, D Levenson, J Treanor, B Kim, S Dewhurst 31/10/2020 The Journal of biological chemistry
SA Coggins, B Mahboubi, RF Schinazi, B Kim 25/09/2020 Tetraspanin CD81 regulates HSV-1 infection.
Medical microbiology and immunology
B Benayas, I Sastre, S López-Martín, A Oo, B Kim, MJ Bullido, J Aldudo, M Yáñez-Mó 01/08/2020