Sumin Kang, PhD
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Research Program
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Phone Number
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Email Address
Biography
Education
Dr. Kang obtained her PhD from Yonsei University in Seoul, Korea. She completed her postdoctoral training at Emory University School of Medicine before joining the faculty in 2009.
Titles & Roles
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Professor, Department of Hematology and Medical OncologyEmory University School of Medicine
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Division Director of Basic and Translational Science, Department of Hematology and Medical OncologyEmory University School of Medicine
Research
Dr. Kang's laboratory focuses on phosphor-proteomics based studies to elucidate signaling mechanisms underlying protein kinase or metabolic enzyme-dependent oncogenesis and tumor metastasis; translational and preclinical studies using in vitro cell assays and in vivo mouse models of tumors and metastases to evaluate small molecule inhibitors to treat human cancers; and studies to elucidate the role of post-translational modifications of protein kinases and metabolic enzymes in pathogenesis and disease progression of human cancers including leukemia and solid tumors.
Grants
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Grant Number Title 5R01CA175316-10 Transcription-dependent and -independent signaling of RSK2 in cancer metastasis Publications
Dr. Kang has extensive publications in major peer-reviewed journals such as Cancer Cell, Molecular Cell, Journal of Clinical Investigation, Molecular and Cellular Biology, Journal of Biological Chemistry and Blood.
Title/Journal Authors Publication Date Proceedings of the National Academy of Sciences of the United States of America
AC Boese, J Kang, JS Hwang, J Kim, K Eun, CM Malin, KR Magliocca, C Pan, L Jin, S Kang 06/06/2023 Cell reports
J Kang, J Chun, JS Hwang, C Pan, J Li, AC Boese, I Young, CM Malin, Y Kang, DL Gibbons, G Sica, H Fu, SS Ramalingam, L Jin, S Kang 13/12/2022 Immunomedicine
AC Boese, JS Hwang, I Young, CM Malin, V Avalos, J Kang, S Kang 01/12/2022 Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.
Nature communications
C Pan, J Kang, JS Hwang, J Li, AC Boese, X Wang, L Yang, TJ Boggon, GZ Chen, NF Saba, DM Shin, KR Magliocca, L Jin, S Kang 16/08/2021 Mitochondrial metabolism-mediated redox regulation in cancer progression.
Redox biology
AC Boese, S Kang 01/06/2021 DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research
J Li, C Pan, AC Boese, J Kang, AD Umano, KR Magliocca, W Yang, Y Zhang, S Lonial, L Jin, S Kang 15/07/2020 New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
JT Poirier, J George, TK Owonikoko, A Berns, E Brambilla, LA Byers, D Carbone, HJ Chen, CL Christensen, C Dive, AF Farago, R Govindan, C Hann, MD Hellmann, L Horn, JE Johnson, YS Ju, S Kang, M Krasnow, J Lee, SH Lee, J Lehman, B Lok, C Lovly, D MacPherson, D McFadden, J Minna, M Oser, K Park, KS Park, Y Pommier, V Quaranta, N Ready, J Sage, G Scagliotti, ML Sos, KD Sutherland, WD Travis, CR Vakoc, SJ Wait, I Wistuba, KK Wong, H Zhang, J Daigneault, J Wiens, CM Rudin, TG Oliver 01/04/2020 Tumor Progression of Breast Cancer during Hyperinsulinemic Obesity.
Trends in molecular medicine
AC Boese, S Kang 01/04/2020 The Journal of clinical investigation
C Pan, J Chun, D Li, AC Boese, J Li, J Kang, A Umano, Y Jiang, L Song, KR Magliocca, ZG Chen, NF Saba, DM Shin, TK Owonikoko, S Lonial, L Jin, S Kang 01/10/2019 The Journal of clinical investigation
C Pan, L Jin, X Wang, Y Li, J Chun, AC Boese, D Li, HB Kang, G Zhang, L Zhou, GZ Chen, NF Saba, DM Shin, KR Magliocca, TK Owonikoko, H Mao, S Lonial, S Kang 13/05/2019 Nature metabolism
F Ni, WM Yu, Z Li, DK Graham, L Jin, S Kang, MR Rossi, S Li, HE Broxmeyer, CK Qu 01/03/2019 Science advances
H Zheng, WM Yu, J Shen, S Kang, D Hambardzumyan, JY Li, Y Shen, AM Kenney, J Chen, CK Qu 01/10/2018 MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
Cancer cell
L Jin, J Chun, C Pan, D Li, R Lin, GN Alesi, X Wang, HB Kang, L Song, D Wang, G Zhang, J Fan, TJ Boggon, L Zhou, J Kowalski, CK Qu, CE Steuer, GZ Chen, NF Saba, LH Boise, TK Owonikoko, FR Khuri, KR Magliocca, DM Shin, S Lonial, S Kang 13/08/2018 A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
L Wang, C Iorio, K Yan, H Yang, S Takeshita, S Kang, BG Neel, W Yang 01/02/2018 Molecular cell
L Jin, J Chun, C Pan, A Kumar, G Zhang, Y Ha, D Li, GN Alesi, Y Kang, L Zhou, WM Yu, KR Magliocca, FR Khuri, CK Qu, C Metallo, TK Owonikoko, S Kang 04/01/2018 Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
Oncogene
L Jin, J Chun, C Pan, GN Alesi, D Li, KR Magliocca, Y Kang, ZG Chen, DM Shin, FR Khuri, J Fan, S Kang 06/07/2017 Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nature communications
Z Zhang, O Obianyo, E Dall, Y Du, H Fu, X Liu, SS Kang, M Song, SP Yu, C Cabrele, M Schubert, X Li, JZ Wang, H Brandstetter, K Ye 27/03/2017 Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Molecular cell
J Fan, R Lin, S Xia, D Chen, SE Elf, S Liu, Y Pan, H Xu, Z Qian, M Wang, C Shan, L Zhou, QY Lei, Y Li, H Mao, BH Lee, J Sudderth, RJ DeBerardinis, G Zhang, T Owonikoko, M Gaddh, ML Arellano, HJ Khoury, FR Khuri, S Kang, PW Doetsch, S Lonial, TJ Boggon, WJ Curran, J Chen 01/12/2016 RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
Oncogene
GN Alesi, L Jin, D Li, KR Magliocca, Y Kang, ZG Chen, DM Shin, FR Khuri, S Kang 13/10/2016 Nature cell biology
R Lin, S Elf, C Shan, HB Kang, Q Ji, L Zhou, T Hitosugi, L Zhang, S Zhang, JH Seo, J Xie, M Tucker, TL Gu, J Sudderth, L Jiang, M Mitsche, RJ DeBerardinis, S Wu, Y Li, H Mao, PR Chen, D Wang, GZ Chen, SJ Hurwitz, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, Q Lei, DJ Brat, K Ye, TJ Boggon, C He, S Kang, J Fan, J Chen 01/11/2015 Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
Molecular cell
HB Kang, J Fan, R Lin, S Elf, Q Ji, L Zhao, L Jin, JH Seo, C Shan, JL Arbiser, C Cohen, D Brat, HM Miziorko, E Kim, O Abdel-Wahab, T Merghoub, S Fröhling, C Scholl, P Tamayo, DA Barbie, L Zhou, BP Pollack, K Fisher, RR Kudchadkar, DH Lawson, G Sica, M Rossi, S Lonial, HJ Khoury, FR Khuri, BH Lee, TJ Boggon, C He, S Kang, J Chen 06/08/2015 Cancer cell
L Jin, D Li, GN Alesi, J Fan, HB Kang, Z Lu, TJ Boggon, P Jin, H Yi, ER Wright, D Duong, NT Seyfried, R Egnatchik, RJ DeBerardinis, KR Magliocca, C He, ML Arellano, HJ Khoury, DM Shin, FR Khuri, S Kang 09/02/2015 The Journal of biological chemistry
J Fan, HB Kang, C Shan, S Elf, R Lin, J Xie, TL Gu, M Aguiar, S Lonning, TW Chung, M Arellano, HJ Khoury, DM Shin, FR Khuri, TJ Boggon, S Kang, J Chen 19/09/2014 Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Molecular cell
C Shan, S Elf, Q Ji, HB Kang, L Zhou, T Hitosugi, L Jin, R Lin, L Zhang, JH Seo, J Xie, M Tucker, TL Gu, J Sudderth, L Jiang, RJ DeBerardinis, S Wu, Y Li, H Mao, PR Chen, D Wang, GZ Chen, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, DJ Brat, K Ye, TJ Boggon, C He, S Kang, J Fan, J Chen 21/08/2014 Molecular cell
J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, S Lonning, H Chen, M Mohammadi, LM Britton, BA Garcia, M Alečković, Y Kang, S Kaluz, N Devi, EG Van Meir, T Hitosugi, JH Seo, S Lonial, M Gaddh, M Arellano, HJ Khoury, FR Khuri, TJ Boggon, S Kang, J Chen 20/02/2014 The Journal of biological chemistry
D Li, L Jin, GN Alesi, YM Kim, J Fan, JH Seo, D Wang, M Tucker, TL Gu, BH Lee, J Taunton, KR Magliocca, ZG Chen, DM Shin, FR Khuri, S Kang 08/11/2013 p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
Molecular and cellular biology
L Jin, D Li, JS Lee, S Elf, GN Alesi, J Fan, HB Kang, D Wang, H Fu, J Taunton, TJ Boggon, M Tucker, TL Gu, ZG Chen, DM Shin, FR Khuri, S Kang 01/07/2013 Nature communications
T Hitosugi, L Zhou, J Fan, S Elf, L Zhang, J Xie, Y Wang, TL Gu, M Alečković, G LeRoy, Y Kang, HB Kang, JH Seo, C Shan, P Jin, W Gong, S Lonial, ML Arellano, HJ Khoury, GZ Chen, DM Shin, FR Khuri, TJ Boggon, S Kang, C He, J Chen 01/01/2013 Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer cell
T Hitosugi, L Zhou, S Elf, J Fan, HB Kang, JH Seo, C Shan, Q Dai, L Zhang, J Xie, TL Gu, P Jin, M Alečković, G LeRoy, Y Kang, JA Sudderth, RJ DeBerardinis, CH Luan, GZ Chen, S Muller, DM Shin, TK Owonikoko, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, K Ye, TJ Boggon, S Kang, C He, J Chen 13/11/2012 Molecular cell
T Hitosugi, J Fan, TW Chung, K Lythgoe, X Wang, J Xie, Q Ge, TL Gu, RD Polakiewicz, JL Roesel, GZ Chen, TJ Boggon, S Lonial, H Fu, FR Khuri, S Kang, J Chen 23/12/2011 Molecular and cellular biology
J Fan, T Hitosugi, TW Chung, J Xie, Q Ge, TL Gu, RD Polakiewicz, GZ Chen, TJ Boggon, S Lonial, FR Khuri, S Kang, J Chen 01/12/2011 Targeting RSK2 in myeloid leukemia: right for FLT3 but wrong for BCR-ABL.
Cell cycle (Georgetown, Tex.)
BH Lee, S Kang 01/11/2011 p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
Blood
S Elf, D Blevins, L Jin, TW Chung, IR Williams, BH Lee, JX Lin, WJ Leonard, J Taunton, HJ Khoury, S Kang 23/06/2011 Anticancer research
M Otsuka, M Mizuki, J Fujita, S Kang, Y Kanakura 01/01/2011 Targeting RSK2 in human malignancies.
Expert opinion on therapeutic targets
S Kang, J Chen 01/01/2011 The Journal of biological chemistry
YT Oh, X Liu, P Yue, S Kang, J Chen, J Taunton, FR Khuri, SY Sun 31/12/2010 The Journal of clinical investigation
S Kang, S Elf, K Lythgoe, T Hitosugi, J Taunton, W Zhou, L Xiong, D Wang, S Muller, S Fan, SY Sun, AI Marcus, TL Gu, RD Polakiewicz, ZG Chen, FR Khuri, DM Shin, J Chen 01/04/2010 Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Science signaling
T Hitosugi, S Kang, MG Vander Heiden, TW Chung, S Elf, K Lythgoe, S Dong, S Lonial, X Wang, GZ Chen, J Xie, TL Gu, RD Polakiewicz, JL Roesel, TJ Boggon, FR Khuri, DG Gilliland, LC Cantley, J Kaufman, J Chen 17/11/2009 Oncogene
CB Chan, X Liu, SW Jang, SI Hsu, I Williams, S Kang, J Chen, K Ye 29/10/2009 Leukemia
S Dong, S Kang, S Lonial, HJ Khoury, J Viallet, J Chen 01/03/2008 The Journal of biological chemistry
S Kang, S Dong, A Guo, H Ruan, S Lonial, HJ Khoury, TL Gu, J Chen 22/02/2008 Cornea
TI Kim, MI Roh, HE Grossniklaus, SJ Kang, SM Hamilton, DF Schorderet, WB Lee, EK Kim 01/01/2008 Cancer cell
S Kang, S Dong, TL Gu, A Guo, MS Cohen, S Lonial, HJ Khoury, D Fabbro, DG Gilliland, PL Bergsagel, J Taunton, RD Polakiewicz, J Chen 01/09/2007 Blood
S Dong, S Kang, TL Gu, S Kardar, H Fu, S Lonial, HJ Khoury, F Khuri, J Chen 01/07/2007 Awards
Dr. Kang is supported with competitive peer-reviewed federal grants including NIH R01 for transcription-dependent and independent signaling of RSK2 in cancer. She has received various prestigious awards including American Cancer Society Basic Research Scholar Award, The Leukemia & Lymphoma Society Special Fellow Award, Georgia Cancer Coalition Cancer Research Award and Robbins Scholar Award.