Richard Kahn, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-3561
Email Address

rkahn@emory.edu

Biography

Richard A. Kahn, PhD, is a professor in the Department of Biochemistry at Emory University School of Medicine. Since arriving to Emory in 1996, Dr. Kahn has been active in contributing to the development of basic science research within the Winship Cancer Institute, serving for four years as director of the Cancer Biology Program.

Prior to Emory, he ran a laboratory in the intramural program of the National Cancer Institute as Section Chief of the Regulatory Mechanisms Section within the Laboratory of Biological Chemistry in the Developmental Therapeutics Program.

Education

Dr. Kahn earned his PhD and MS degrees in Pharmacology from Yale University.

Titles & Roles

Professor, Department of Biochemistry

Emory University School of Medicine

Research

Throughout Dr. Kahn's career, his laboratory has focused on aspects of cell regulation by GTPases, particularly those in the Arf family, within the larger Ras superfamily. His lab continues to study cell signaling today.

Grants

View Grants

Grant Number	Title
2R35GM122568-06	Molecular mechanisms of ARF family GTPases
5R35GM122568-07	Molecular mechanisms of ARF family GTPases

Publications

Dr. Kahn is published in numerous peer-reviewed publications and he is associate editor of Cellular Logistics and Small GTPases.

Title/Journal	Authors	Publication Date
Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge. mAbs	M Biddle, P Stylianou, M Rekas, A Wright, J Sousa, D Ruddy, MI Stefana, K Kmiecik, A Bandrowski, RA Kahn, C Laflamme, EM Krockow, HS Virk	01/01/2024
The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi. Frontiers in cell and developmental biology	JM Meissner, K Akhmetova, T Szul, EG Viktorova, B Sha, JM Bhatt, EJ Lee, RA Kahn, GA Belov, I Chesnokov, E Sztul	01/01/2023
Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E. Molecular biology of the cell	SI Dewees, R Vargová, KR Hardin, RE Turn, S Devi, J Linnert, U Wolfrum, T Caspary, M Eliáš, RA Kahn	01/04/2022
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic. Molecular biology of the cell	RE Turn, Y Hu, SI Dewees, N Devi, MP East, KR Hardin, T Khatib, J Linnert, U Wolfrum, MJ Lim, JE Casanova, T Caspary, RA Kahn	01/02/2022
A Eukaryote-Wide Perspective on the Diversity and Evolution of the ARF GTPase Protein Family. Genome biology and evolution	R Vargová, JG Wideman, R Derelle, V Klimeš, RA Kahn, JB Dacks, M Eliáš	03/08/2021
Roles for ELMOD2 and Rootletin in ciliogenesis. Molecular biology of the cell	RE Turn, J Linnert, ED Gigante, U Wolfrum, T Caspary, RA Kahn	15/04/2021
The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis. Molecular biology of the cell	RE Turn, MP East, R Prekeris, RA Kahn	15/08/2020
ARF family GTPases with links to cilia. American journal of physiology. Cell physiology	S Fisher, D Kuna, T Caspary, RA Kahn, E Sztul	01/08/2020
ARL13B regulates Sonic hedgehog signaling from outside primary cilia. eLife	ED Gigante, MR Taylor, AA Ivanova, RA Kahn, T Caspary	04/03/2020
Homozygous Variant in ARL3 Causes Autosomal Recessive Cone Rod Dystrophy. Investigative ophthalmology & visual science	SA Sheikh, RA Sisk, CR Schiavon, YM Waryah, MA Usmani, DH Steel, JA Sayer, AK Narsani, RB Hufnagel, S Riazuddin, RA Kahn, AM Waryah, ZM Ahmed	01/11/2019
Ancient complement and lineage-specific evolution of the Sec7 ARF GEF proteins in eukaryotes. Molecular biology of the cell	SV Pipaliya, A Schlacht, CM Klinger, RA Kahn, J Dacks	15/07/2019
ARF GTPases and their GEFs and GAPs: concepts and challenges. Molecular biology of the cell	E Sztul, PW Chen, JE Casanova, J Cherfils, JB Dacks, DG Lambright, FS Lee, PA Randazzo, LC Santy, A Schürmann, I Wilhelmi, ME Yohe, RA Kahn	15/05/2019
ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2. Molecular biology of the cell	CR Schiavon, RE Turn, LE Newman, RA Kahn	01/05/2019
Compositional complexity of rods and rings. Molecular biology of the cell	CR Schiavon, ME Griffin, M Pirozzi, R Parashuraman, W Zhou, HA Jinnah, D Reines, RA Kahn	15/09/2018
The ARF guanine nucleotide exchange factor GBF1 is targeted to Golgi membranes through a PIP-binding domain. Journal of cell science	JM Meissner, JM Bhatt, E Lee, ML Styers, AA Ivanova, RA Kahn, E Sztul	05/02/2018
A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. European journal of human genetics : EJHG	R Rafiullah, AB Long, AA Ivanova, H Ali, S Berkel, G Mustafa, N Paramasivam, M Schlesner, S Wiemann, RC Wade, E Bolthauser, M Blum, RA Kahn, T Caspary, GA Rappold	01/12/2017
Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin. Journal of molecular biology	JW Francis, D Goswami, SJ Novick, BD Pascal, ER Weikum, EA Ortlund, PR Griffin, RA Kahn	24/11/2017
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF). The Journal of biological chemistry	AA Ivanova, T Caspary, NT Seyfried, DM Duong, AB West, Z Liu, RA Kahn	30/06/2017
A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network. The Journal of biological chemistry	JW Francis, LE Newman, LA Cunningham, RA Kahn	10/03/2017
The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space. Cellular logistics	LE Newman, CR Schiavon, RE Turn, RA Kahn	01/01/2017
Mistakes in translation: Reflections on mechanism. PloS one	Y Liu, JS Sharp, DH Do, RA Kahn, H Schwalbe, F Buhr, JH Prestegard	01/01/2017
The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors. PloS one	LE Newman, CR Schiavon, C Zhou, RA Kahn	01/01/2017
Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy. American journal of human genetics	E Flex, M Niceta, S Cecchetti, I Thiffault, MG Au, A Capuano, E Piermarini, AA Ivanova, JW Francis, G Chillemi, B Chandramouli, G Carpentieri, CA Haaxma, A Ciolfi, S Pizzi, GV Douglas, K Levine, A Sferra, ML Dentici, RR Pfundt, JB Le Pichon, E Farrow, F Baas, F Piemonte, B Dallapiccola, JM Graham, CJ Saunders, E Bertini, RA Kahn, DA Koolen, M Tartaglia	06/10/2016
Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions. Small GTPases	JW Francis, RE Turn, LE Newman, C Schiavon, RA Kahn	01/10/2016
Special Issue: GTPases in trafficking, autophagy, and disease (FASEB SRC). Small GTPases	RA Kahn, D Lambright, A De Matteis	01/10/2016
Arl13b regulates Shh signaling from both inside and outside the cilium. Molecular biology of the cell	LE Mariani, MF Bijlsma, AA Ivanova, SK Suciu, RA Kahn, T Caspary	28/09/2016
Use of a Grant Writing Class in Training PhD Students. Traffic (Copenhagen, Denmark)	RA Kahn, GL Conn, GK Pavlath, AH Corbett	01/07/2016
Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation. American journal of physiology. Cell physiology	JM Bhatt, EG Viktorova, T Busby, P Wyrozumska, LE Newman, H Lin, E Lee, J Wright, GA Belov, RA Kahn, E Sztul	15/03/2016
Arl13b and the exocyst interact synergistically in ciliogenesis. Molecular biology of the cell	C Seixas, SY Choi, N Polgar, NL Umberger, MP East, X Zuo, H Moreiras, R Ghossoub, A Benmerah, RA Kahn, B Fogelgren, T Caspary, JH Lipschutz, DC Barral	15/01/2016
Plasmids for variable expression of proteins targeted to the mitochondrial matrix or intermembrane space. Cellular logistics	LE Newman, C Schiavon, RA Kahn	01/01/2016
LRRK2 autophosphorylation enhances its GTPase activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	Z Liu, JA Mobley, LJ DeLucas, RA Kahn, AB West	01/01/2016
A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1. Structure (London, England : 1993)	RA Kahn, DG Lambright	03/11/2015
Tool box: Plasmids for the expression or knockdown of human ARF Family GTPases (ARF/ARL/SAR) and their co-expression in bacteria with N-myristoyltransferases. Cellular logistics	SC Kerr, RA Kahn	01/01/2015
Reverse two-hybrid techniques in the yeast Saccharomyces cerevisiae. Methods in molecular biology (Clifton, N.J.)	MA Bennett, JF Shern, RA Kahn	01/01/2015
Is the model of signal amplification by GPCRs/GEFs activating multiple GTPases relevant to a broad spectrum of heterotrimeric and RAS superfamily GTPases? Cellular logistics	RA Kahn	01/06/2014
Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases. The Journal of biological chemistry	AA Ivanova, MP East, SL Yi, RA Kahn	18/04/2014
Interaction of Fapp1 with Arf1 and PI4P at a membrane surface: an example of coincidence detection. Structure (London, England : 1993)	Y Liu, RA Kahn, JH Prestegard	04/03/2014
The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels. PloS one	LE Newman, CJ Zhou, S Mudigonda, AL Mattheyses, E Paradies, CM Marobbio, RA Kahn	01/01/2014
Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex. The Journal of biological chemistry	AH Caster, RA Kahn	04/10/2013
Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa. American journal of human genetics	AE Davidson, N Schwarz, L Zelinger, G Stern-Schneider, A Shoemark, B Spitzbarth, M Gross, U Laxer, J Sosna, PI Sergouniotis, NH Waseem, R Wilson, RA Kahn, V Plagnol, U Wolfrum, E Banin, AJ Hardcastle, ME Cheetham, D Sharon, AR Webster	08/08/2013
Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Traffic (Copenhagen, Denmark)	A Schlacht, K Mowbrey, M Elias, RA Kahn, JB Dacks	01/06/2013
A role for cargo in Arf-dependent adaptor recruitment. The Journal of biological chemistry	AH Caster, E Sztul, RA Kahn	24/05/2013
An alteration in ELMOD3, an Arl2 GTPase-activating protein, is associated with hearing impairment in humans. PLoS genetics	TJ Jaworek, EM Richard, AA Ivanova, AP Giese, DI Choo, SN Khan, S Riazuddin, RA Kahn, S Riazuddin	01/01/2013
ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases. The Journal of biological chemistry	MP East, JB Bowzard, JB Dacks, RA Kahn	16/11/2012
Computational method for calculating fluorescence intensities within three-dimensional structures in cells. Cellular logistics	AH Caster, RA Kahn	01/10/2012
GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production. Molecular biology of the cell	JH Herskowitz, K Offe, A Deshpande, RA Kahn, AI Levey, JJ Lah	01/07/2012
Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins. Molecular biology of the cell	CE Larkins, GD Aviles, MP East, RA Kahn, T Caspary	01/12/2011
Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation. The Journal of biological chemistry	V Popoff, JD Langer, I Reckmann, A Hellwig, RA Kahn, B Brügger, FT Wieland	14/10/2011
GAPs: Terminator versus effector functions and the role(s) of ArfGAP1 in vesicle biogenesis. Cellular logistics	RA Kahn	01/03/2011
Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. The Journal of biological chemistry	JH Herskowitz, NT Seyfried, M Gearing, RA Kahn, J Peng, AI Levey, JJ Lah	25/02/2011
Models for the functions of Arf GAPs. Seminars in cell & developmental biology	MP East, RA Kahn	01/02/2011
The Cellular Logistics Blog (CellLogBlog): A place for reviews and reasoned debate. Cellular logistics	RA Kahn, A Luini, N Segev	01/01/2011
ADP ribosylation factors 1 and 4 and group VIA phospholipase A₂ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment. Molecular biology of the cell	H Ben-Tekaya, RA Kahn, HP Hauri	01/12/2010
Dynamic structure of membrane-anchored Arf*GTP. Nature structural & molecular biology	Y Liu, RA Kahn, JH Prestegard	01/07/2010
Modifications to the C-terminus of Arf1 alter cell functions and protein interactions. Traffic (Copenhagen, Denmark)	X Jian, M Cavenagh, JM Gruschus, PA Randazzo, RA Kahn	01/06/2010
Toward a model for Arf GTPases as regulators of traffic at the Golgi. FEBS letters	RA Kahn	03/12/2009
Consensus nomenclature for the human ArfGAP domain-containing proteins. The Journal of cell biology	RA Kahn, E Bruford, H Inoue, JM Logsdon, Z Nie, RT Premont, PA Randazzo, M Satake, AB Theibert, ML Zapp, D Cassel	22/09/2008
Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle. The Journal of biological chemistry	LA Cunningham, RA Kahn	14/03/2008
Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network. Molecular biology of the cell	P Shrivastava-Ranjan, V Faundez, G Fang, H Rees, JJ Lah, AI Levey, RA Kahn	01/01/2008