Selwyn Hurwitz, PhD, MSc

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-727-1462
Email Address

shurwit@emory.edu

Biography

Selwyn J. Hurwitz, PhD, MSc, is an assistant professor in Department of Pediatrics, Laboratory of Biochemical Pharmacology at Emory University School of Medicine. Dr. Horowitz is an investigator in the Center for AIDS Research at Emory University and a member of the Discovery and Developmental Therapeutics Research Program at Winship.

Education

Dr. Hurwitz earned his PhD in Biopharmaceutics from Massachusetts College of Pharmacy and Health Sciences. He then completed a postdoctoral fellowship in the Division of Cancer Pharmacology at Dana-Farber Cancer Institute. Dr. Hurwitz also holds an MSc in Biochemistry.

Titles & Roles

Assistant Professor, Department of Pediatrics

Emory University School of Medicine
Investigator, Center for AIDS Research

Emory University

Title/Journal	Authors	Publication Date
Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections. Viruses	SJ Hurwitz, R De, JC LeCher, JA Downs-Bowen, SL Goh, K Zandi, T McBrayer, F Amblard, D Patel, JJ Kohler, M Bhasin, BS Dobosh, V Sukhatme, RM Tirouvanziam, RF Schinazi	22/04/2024
Randomized Trial of Ruxolitinib in Antiretroviral-Treated Adults With Human Immunodeficiency Virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	VC Marconi, C Moser, C Gavegnano, SG Deeks, MM Lederman, ET Overton, A Tsibris, PW Hunt, A Kantor, RP Sekaly, R Tressler, C Flexner, SJ Hurwitz, D Moisi, B Clagett, WR Hardin, C Del Rio, RF Schinazi, JJ Lennox	07/01/2022
Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agent Therapy from the ACTG A5336 Study. Journal of clinical pharmacology	SJ Hurwitz, S Tao, C Gavegnano, Y Jiang, RL Tressler, A Tsibris, C Del Rio, ET Overton, MM Lederman, A Kantor, C Moser, JJ Kohler, J Lennox, VC Marconi, CW Flexner, RF Schinazi	01/12/2021
Non-alcoholic fatty liver disease is a risk factor for occurrence of hepatocellular carcinoma after sustained virologic response in chronic hepatitis C patients: A prospective four-years follow-up study. Metabolism open	D Ji, GF Chen, XX Niu, M Zhang, C Wang, Q Shao, V Wu, Y Wang, G Cheng, SJ Hurwitz, RF Schinazi, G Lau	01/06/2021
Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator. Viruses	SJ Hurwitz, N McBrearty, A Arzumanyan, E Bichenkov, S Tao, L Bassit, Z Chen, JJ Kohler, F Amblard, MA Feitelson, RF Schinazi	15/01/2021
Novel method to quantify phenotypic markers of HIV-associated neurocognitive disorder in a murine SCID model. Journal of neurovirology	C Gavegnano, W Haile, R Koneru, SJ Hurwitz, JJ Kohler, WR Tyor, RF Schinazi	01/12/2020
Corrigendum: Systemic Delivery of Bc12-Targeting siRNA by DNA Nanoparticles Suppresses Cancer Cell Growth. Angewandte Chemie (International ed. in English)	MA Rahman, P Wang, Z Zhao, D Wang, S Nannapaneni, C Zhang, Z Chen, CC Griffith, SJ Hurwitz, ZG Chen, Y Ke, DM Shin	27/07/2020
Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro. Journal of neuroinflammation	C Gavegnano, WB Haile, S Hurwitz, S Tao, Y Jiang, RF Schinazi, WR Tyor	27/09/2019
Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers. Antimicrobial agents and chemotherapy	NG Rouphael, SJ Hurwitz, M Hart, A Beck, EJ Anderson, G Deye, B Osborn, SY Cai, C Focht, C Amegashie, TL Bowlin, J Brooks, MJ Mulligan	01/09/2019
Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells. Journal of the American Chemical Society	P Wang, MA Rahman, Z Zhao, K Weiss, C Zhang, Z Chen, SJ Hurwitz, ZG Chen, DM Shin, Y Ke	21/02/2018
Systemic Delivery of Bc12-Targeting siRNA by DNA Nanoparticles Suppresses Cancer Cell Growth. Angewandte Chemie (International ed. in English)	MA Rahman, P Wang, Z Zhao, D Wang, S Nannapaneni, C Zhang, Z Chen, CC Griffith, SJ Hurwitz, ZG Chen, Y Ke, DM Shin	11/12/2017
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors. PLoS pathogens	C Gavegnano, JH Brehm, FP Dupuy, A Talla, SP Ribeiro, DA Kulpa, C Cameron, S Santos, SJ Hurwitz, VC Marconi, JP Routy, L Sabbagh, RF Schinazi, RP Sékaly	01/12/2017
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nature cell biology	R Lin, S Elf, C Shan, HB Kang, Q Ji, L Zhou, T Hitosugi, L Zhang, S Zhang, JH Seo, J Xie, M Tucker, TL Gu, J Sudderth, L Jiang, M Mitsche, RJ DeBerardinis, S Wu, Y Li, H Mao, PR Chen, D Wang, GZ Chen, SJ Hurwitz, S Lonial, ML Arellano, HJ Khoury, FR Khuri, BH Lee, Q Lei, DJ Brat, K Ye, TJ Boggon, C He, S Kang, J Fan, J Chen	01/11/2015
Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck. Cancer	NF Saba, SJ Hurwitz, K Magliocca, S Kim, TK Owonikoko, D Harvey, SS Ramalingam, Z Chen, J Rogerio, J Mendel, SA Kono, C Lewis, AY Chen, K Higgins, M El-Deiry, T Wadsworth, JJ Beitler, DM Shin, SY Sun, FR Khuri	15/12/2014
Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics. Antimicrobial agents and chemotherapy	TW North, A Villalobos, SJ Hurwitz, JD Deere, J Higgins, P Chatterjee, S Tao, RC Kauffman, PA Luciw, JJ Kohler, RF Schinazi	01/07/2014
Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women. Antimicrobial agents and chemotherapy	WM Geisler, ML Pascual, J Mathew, WD Koltun, F Morgan, BE Batteiger, A Mayes, S Tao, SJ Hurwitz, C Sayada, RF Schinazi	01/07/2014
Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer prevention research (Philadelphia, Pa.)	NF Saba, SJ Hurwitz, SA Kono, CS Yang, Y Zhao, Z Chen, G Sica, S Müller, R Moreno-Williams, M Lewis, W Grist, AY Chen, CE Moore, TK Owonikoko, S Ramalingam, JJ Beitler, S Nannapaneni, HJ Shin, JR Grandis, FR Khuri, ZG Chen, DM Shin	01/03/2014
Approaches to hepatitis C treatment and cure using NS5A inhibitors. Infection and drug resistance	JJ Kohler, JH Nettles, F Amblard, SJ Hurwitz, L Bassit, RA Stanton, M Ehteshami, RF Schinazi	01/01/2014
Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors. Current opinion in HIV and AIDS	SJ Hurwitz, RF Schinazi	01/11/2013
Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages. Antimicrobial agents and chemotherapy	C Gavegnano, MA Detorio, L Bassit, SJ Hurwitz, TW North, RF Schinazi	01/03/2013
Pharmacodynamics of DT-IgG, a dual-targeting antibody against VEGF-EGFR, in tumor xenografted mice. Cancer chemotherapy and pharmacology	SJ Hurwitz, H Zhang, S Yun, TD Batuwangala, M Steward, SD Holmes, D Rycroft, L Pan, M Tighiouart, HJ Shin, L Koenig, Y Wang, ZG Chen, DM Shin	01/03/2012
Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors. Drug discovery today. Technologies	SJ Hurwitz, RF Schinazi	01/01/2012
In silico study supports the efficacy of a reduced dose regimen for stavudine. Antiviral research	SJ Hurwitz, RF Schinazi	01/11/2011
Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals. Antimicrobial agents and chemotherapy	SJ Hurwitz, G Asif, E Fromentin, PM Tharnish, RF Schinazi	01/03/2010
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences	E Fromentin, G Asif, A Obikhod, SJ Hurwitz, RF Schinazi	01/11/2009
Sequence dependence of cell growth inhibition by EGFR-tyrosine kinase inhibitor ZD1839, docetaxel, and cisplatin in head and neck cancer. Head & neck	CM Klass, MS Choe, SJ Hurwitz, M Tighiouart, X Zhang, ZG Chen, DM Shin	01/10/2009
Approaches for the development of antiviral compounds: the case of hepatitis C virus. Handbook of experimental pharmacology	RF Schinazi, SJ Coats, LC Bassit, J Lennerstrand, JH Nettles, SJ Hurwitz	01/01/2009