Jason Fangusaro, MD
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Research Program
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Email Address
Biography
Jason Fangusaro, MD, is director of Developmental Therapeutics at the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta. Dr. Fangusaro is also Professor of Pediatrics at the Emory University School of Medicine and the Carter S. Martin Endowed Chair. As a clinical member of the pediatric neuro-oncology team, he specializes in treating children with central nervous system malignancies, including brain and spinal cord tumors. He is a is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.
Education
Dr. Fangusaro received his MD from Loyola University Stritch School of Medicine in Chicago, Illinois. He did his residency at Lutheran General Children's Hospital in Chicago, Illinois. He completed a Pediatric Hematology/Oncology Fellowship at Nationwide Children's Hospital in Columbus, Ohio, and a Pediatric Neuro-Oncology Fellowship at Children's Hospital of Los Angeles in California.
Titles & Roles
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Professor, Department of PediatricsEmory University School of Medicine
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Director of Developmental TherapeuticsAflac Cancer and Blood Disorders Center
Professional Memberships
Dr. Fangusaro is a member of the Children's Oncology Group Brain Tumor Steering Committee, serves as the vice chair of the Pediatric Brain Tumor Consortium and partners with the pharmaceutical industry on investigator-initiated trials. He holds professional memberships with American Society of Clinical Oncology, Society for Neuro-Oncology and Children's Oncology Group.
Research
Dr. Fangusaro's primary area of research is the development of early phase clinical trials, novel therapeutics and relevant biologic correlates in an effort to improve survival outcomes and minimize toxicities. Within pediatric brain tumors, his research has focused on two main areas: low grade gliomas (LGG) and central nervous system (CNS) germ cell tumors (GCTs).
He is a member of both the LGG and CNS GCT international consensus panels, and also serves as the principal investigator and co-investigator on numerous national trials.
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Grants
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Title/Journal Authors Publication Date Neuro-oncology
S Mueller, J Fangusaro, AO Thomas, TS Jacques, P Bandopadhayay, P de Blank, RJ Packer, M Fouladi, AS van Meeteren, D Jones, A Perry, Y Nakano, D Hargrave, D Riedl, NJ Robison, M Partanen, MJ Fisher, O Witt 04/03/2024 Clinical cancer research : an official journal of the American Association for Cancer Research
J Fangusaro, RA Avery, MJ Fisher, RJ Packer, KS Walsh, A Schouten-van Meeteren, D Karres, D Bradford, V Bhatnagar, H Singh, PG Kluetz, M Donoghue, ES Duke 15/02/2024 Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial.
Neuro-oncology
TS Johnson, TJ MacDonald, R Pacholczyk, D Aguilera, A Al-Basheer, M Bajaj, P Bandopadhayay, Z Berrong, E Bouffet, RC Castellino, K Dorris, BR Eaton, N Esiashvili, JR Fangusaro, N Foreman, D Fridlyand, C Giller, IM Heger, C Huang, N Kadom, EP Kennedy, N Manoharan, W Martin, C McDonough, RS Parker, V Ramaswamy, E Ring, A Rojiani, RF Sadek, S Satpathy, M Schniederjan, A Smith, C Smith, BE Thomas, R Vaizer, KK Yeo, MK Bhasin, DH Munn 02/02/2024 Primary Diffuse Leptomeningeal Melanomatosis in a Child with Extracranial Metastasis: Case Report.
Current oncology (Toronto, Ont.)
SW Shahab, P Patil, JR Fangusaro, B Patteson, A Goldman-Yassen, BR Eaton, W Boydston, M Schniederjan, D Aguilera 20/01/2024 Pediatric low-grade glioma: State-of-the-art and ongoing challenges.
Neuro-oncology
J Fangusaro, DT Jones, RJ Packer, DH Gutmann, T Milde, O Witt, S Mueller, MJ Fisher, JR Hansford, U Tabori, D Hargrave, P Bandopadhayay 05/01/2024 Neuro-oncology
M Monje, T Cooney, J Glod, J Huang, CJ Peer, D Faury, P Baxter, K Kramer, A Lenzen, NJ Robison, L Kilburn, A Vinitsky, WD Figg, N Jabado, M Fouladi, J Fangusaro, A Onar-Thomas, IJ Dunkel, KE Warren 08/12/2023 Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation.
Neuro-oncology
T Milde, J Fangusaro, MJ Fisher, C Hawkins, FJ Rodriguez, U Tabori, O Witt, Y Zhu, DH Gutmann 02/11/2023 Children's Oncology Group's 2023 blueprint for research: Central nervous system tumors.
Pediatric blood & cancer
SES Leary, A Onar-Thomas, J Fangusaro, NG Gottardo, K Cohen, A Smith, A Huang, D Haas-Kogan, M Fouladi 01/09/2023 Cancers
N Pillay-Smiley, J Leach, A Lane, T Hummel, J Fangusaro, P de Blank 31/03/2023 Neoplasia (New York, N.Y.)
JV Lilly, JL Rokita, JL Mason, T Patton, S Stefankiewiz, D Higgins, G Trooskin, CA Larouci, K Arya, E Appert, AP Heath, Y Zhu, MA Brown, B Zhang, BK Farrow, S Robins, AM Morgan, TQ Nguyen, E Frenkel, K Lehmann, E Drake, C Sullivan, A Plisiewicz, N Coleman, L Patterson, M Koptyra, Z Helili, N Van Kuren, N Young, MC Kim, C Friedman, A Lubneuski, C Blackden, M Williams, V Baubet, L Tauhid, J Galanaugh, K Boucher, H Ijaz, KA Cole, N Choudhari, M Santi, RW Moulder, J Waller, W Rife, SJ Diskin, M Mateos, DW Parsons, IF Pollack, S Goldman, S Leary, C Caporalini, AM Buccoliero, M Scagnet, D Haussler, D Hanson, R Firestein, J Cain, JJ Phillips, N Gupta, S Mueller, G Grant, M Monje-Deisseroth, S Partap, JP Greenfield, R Hashizume, A Smith, S Zhu, JM Johnston, JR Fangusaro, M Miller, MD Wood, S Gardner, CL Carter, LM Prolo, J Pisapia, K Pehlivan, A Franson, T Niazi, J Rubin, M Abdelbaki, DS Ziegler, HB Lindsay, AG Stucklin, N Gerber, OM Vaske, C Quinsey, BR Rood, J Nazarian, E Raabe, EM Jackson, S Stapleton, RM Lober, DE Kram, C Koschmann, PB Storm, RR Lulla, M Prados, AC Resnick, AJ Waanders 01/01/2023 European journal of cancer (Oxford, England : 1990)
AD Pearson, C Allen, J Fangusaro, C Hutter, O Witt, S Weiner, G Reaman, M Russo, P Bandopadhayay, S Ahsan, A Barone, E Barry, T de Rojas, M Fisher, E Fox, JG Bender, L Gore, D Hargrave, D Hawkins, B Kreider, AJ Langseth, G Lesa, F Ligas, M Marotti, LV Marshall, K Nasri, K Norga, K Nysom, A Pappo, G Rossato, N Scobie, M Smith, E Stieglitz, B Weigel, A Weinstein, R Viana, D Karres, G Vassal 01/12/2022 MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus.
Neuro-oncology
PMK de Blank, AM Gross, S Akshintala, JO Blakeley, G Bollag, A Cannon, E Dombi, J Fangusaro, BD Gelb, D Hargrave, A Kim, LJ Klesse, M Loh, S Martin, C Moertel, R Packer, JM Payne, KA Rauen, JJ Rios, N Robison, EK Schorry, K Shannon, DA Stevenson, E Stieglitz, NJ Ullrich, KS Walsh, BD Weiss, PL Wolters, K Yohay, ME Yohe, BC Widemann, MJ Fisher 02/11/2022 Neuro-oncology
A Fonseca, C Faure-Conter, MJ Murray, J Fangusaro, S Bailey, S Goldman, S Khatua, D Frappaz, G Calaminus, G Dhall, JC Nicholson, E Bouffet, U Bartels 02/11/2022 Nervous system (NS) Tumors in Cancer Predisposition Syndromes.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
P Patil, BB Pencheva, VM Patil, J Fangusaro 01/10/2022 JCO precision oncology
M Dankner, Y Wang, R Fazelzad, B Johnson, CA Nebhan, I Dagogo-Jack, NJ Myall, G Richtig, JWP Bracht, M Gerlinger, E Shinozaki, T Yoshino, D Kotani, JR Fangusaro, O Gautschi, J Mazieres, JA Sosman, S Kopetz, V Subbiah, MA Davies, AL Groover, RJ Sullivan, KT Flaherty, DB Johnson, A Benedetti, DW Cescon, A Spreafico, G Zogopoulos, AAN Rose 01/08/2022 Neuro-oncology
JR Fangusaro, A Onar-Thomas, TY Poussaint, S Wu, AH Ligon, NI Lindeman, A Banerjee, R Packer, LB Kilburn, IF Pollack, IA Qaddoumi, PG Fisher, G Dhall, PA Baxter, SG Kreissman, LA Doyle, MA Smith, M Fouladi, IJ Dunkel 01/08/2022 Neuro-oncology
U Bartels, A Onar-Thomas, SK Patel, D Shaw, J Fangusaro, G Dhall, M Souweidane, A Bhatia, L Embry, CL Trask, ES Murphy, S MacDonald, S Wu, JM Boyett, S Leary, M Fouladi, A Gajjar, S Khatua 01/06/2022 International journal of radiation oncology, biology, physics
ES Murphy, G Dhall, J Fangusaro, U Bartels, M Fouladi, D Shaw, S Khatua, CW Hughes, A Panigraphy, M Ioakeim-Ioannidou, M Souweidane, D Morris, A Gajjar, S Wu, A Onar-Thomas, DA Haas-Kogan, SM MacDonald 01/05/2022 The Lancet. Oncology
G Morana, D Shaw, SM MacDonald, C Alapetite, T Ajithkumar, A Bhatia, H Brisse, C Jaimes, T Czech, G Dhall, J Fangusaro, C Faure-Conter, M Fouladi, D Hargrave, JH Harreld, D Mitra, JC Nicholson, M Souweidane, B Timmermann, G Calaminus, U Bartels, B Bison, MJ Murray 01/05/2022 JCO precision oncology
RJ Summers, SM Castellino, CC Porter, TJ MacDonald, GD Basu, S Szelinger, MK Bhasin, T Cash, AB Carter, RC Castellino, JR Fangusaro, SG Mitchell, MG Pauly, B Pencheva, DS Wechsler, DK Graham, KC Goldsmith 01/04/2022 Multicenter Analysis of Genomically Targeted Single Patient Use Requests for Pediatric Neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
HS Sabnis, DS Shulman, B Mizukawa, N Bouvier, A Zehir, J Fangusaro, VA Fabrizio, C Whitlow, M Winchester, L Agresta, B Turpin, DS Wechsler, SG DuBois, J Glade-Bender, SM Castellino, N Shukla 01/12/2021 Neuro-oncology
J Fangusaro, A Onar-Thomas, TY Poussaint, S Wu, AH Ligon, N Lindeman, O Campagne, A Banerjee, S Gururangan, LB Kilburn, S Goldman, I Qaddoumi, P Baxter, G Vezina, C Bregman, Z Patay, JY Jones, CF Stewart, MJ Fisher, LA Doyle, M Smith, IJ Dunkel, M Fouladi 01/10/2021 Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib.
Clinical pharmacokinetics
O Campagne, KK Yeo, J Fangusaro, CF Stewart 01/03/2021 Neonatal Central Nervous System Tumors.
Clinics in perinatology
S Shahab, J Fangusaro 01/03/2021 Advances in the classification and treatment of pediatric brain tumors.
Current opinion in pediatrics
J Fangusaro, P Bandopadhayay 01/02/2021 Pediatric blood & cancer
J Fangusaro, DA Mitchell, M Kocak, GW Robinson, PA Baxter, EI Hwang, J Huang, A Onar-Thomas, IJ Dunkel, M Fouladi, KE Warren 01/02/2021 Frontiers in oncology
J Fangusaro, MG Cefalo, ML Garré, LV Marshall, M Massimino, B Benettaib, N Biserna, J Poon, J Quan, E Conlin, J Lewandowski, M Simcock, N Jeste, DR Hargrave, F Doz, KE Warren 01/01/2021 Neuro-oncology
RJ Packer, A Iavarone, DTW Jones, JO Blakeley, E Bouffet, MJ Fisher, E Hwang, C Hawkins, L Kilburn, T MacDonald, SM Pfister, B Rood, FJ Rodriguez, U Tabori, V Ramaswamy, Y Zhu, J Fangusaro, SA Johnston, DH Gutmann 09/06/2020 Pineoblastoma in children less than six years of age: The Head Start I, II, and III experience.
Pediatric blood & cancer
MS Abdelbaki, MH Abu-Arja, TB Davidson, JR Fangusaro, JR Stanek, IJ Dunkel, G Dhall, SL Gardner, JL Finlay 01/06/2020 The Lancet. Oncology
J Fangusaro, O Witt, P Hernáiz Driever, AK Bag, P de Blank, N Kadom, L Kilburn, RM Lober, NJ Robison, MJ Fisher, RJ Packer, T Young Poussaint, L Papusha, S Avula, AA Brandes, E Bouffet, D Bowers, A Artemov, M Chintagumpala, D Zurakowski, M van den Bent, B Bison, KW Yeom, W Taal, KE Warren 01/06/2020 The "Risk" in Pediatric Low-Grade Glioma.
Cancer cell
J Fangusaro, P Bandopadhayay 13/04/2020 Acta neuropathologica
BK Li, A Vasiljevic, C Dufour, F Yao, BLB Ho, M Lu, EI Hwang, S Gururangan, JR Hansford, M Fouladi, S Nobusawa, A Laquerriere, MB Delisle, J Fangusaro, F Forest, H Toledano, P Solano-Paez, S Leary, D Birks, LM Hoffman, A Szathmari, C Faure-Conter, X Fan, D Catchpoole, L Zhou, KAP Schultz, K Ichimura, G Gauchotte, N Jabado, C Jones, D Loussouarn, K Mokhtari, A Rousseau, DS Ziegler, S Tanaka, SL Pomeroy, A Gajjar, V Ramaswamy, C Hawkins, RG Grundy, DA Hill, E Bouffet, A Huang, A Jouvet 01/02/2020 Journal of clinical oncology : official journal of the American Society of Clinical Oncology
J Fangusaro, S Wu, S MacDonald, E Murphy, D Shaw, U Bartels, S Khatua, M Souweidane, HM Lu, D Morris, A Panigrahy, A Onar-Thomas, M Fouladi, A Gajjar, G Dhall 01/12/2019 Neuro-oncology
JP Gross, S Powell, F Zelko, W Hartsell, S Goldman, J Fangusaro, RR Lulla, NP Smiley, JH Chang, V Gondi 11/07/2019 Cancer cell
P Sin-Chan, I Mumal, T Suwal, B Ho, X Fan, I Singh, Y Du, M Lu, N Patel, J Torchia, D Popovski, M Fouladi, P Guilhamon, JR Hansford, S Leary, LM Hoffman, JM Mulcahy Levy, A Lassaletta, P Solano-Paez, E Rivas, A Reddy, GY Gillespie, N Gupta, TE Van Meter, H Nakamura, TT Wong, YS Ra, SK Kim, L Massimi, RG Grundy, J Fangusaro, D Johnston, J Chan, L Lafay-Cousin, EI Hwang, Y Wang, D Catchpoole, J Michaud, B Ellezam, R Ramanujachar, H Lindsay, MD Taylor, CE Hawkins, E Bouffet, N Jabado, SK Singh, CL Kleinman, D Barsyte-Lovejoy, XN Li, PB Dirks, CY Lin, SC Mack, JN Rich, A Huang 08/07/2019 The Lancet. Oncology
J Fangusaro, A Onar-Thomas, T Young Poussaint, S Wu, AH Ligon, N Lindeman, A Banerjee, RJ Packer, LB Kilburn, S Goldman, IF Pollack, I Qaddoumi, RI Jakacki, PG Fisher, G Dhall, P Baxter, SG Kreissman, CF Stewart, DTW Jones, SM Pfister, G Vezina, JS Stern, A Panigrahy, Z Patay, B Tamrazi, JY Jones, SS Haque, DS Enterline, S Cha, MJ Fisher, LA Doyle, M Smith, IJ Dunkel, M Fouladi 01/07/2019 Science signaling
THW Dobson, RH Tao, J Swaminathan, S Maegawa, S Shaik, J Bravo-Alegria, A Sharma, B Kennis, Y Yang, K Callegari, AR Haltom, P Taylor, M Kogiso, L Qi, S Khatua, S Goldman, RR Lulla, J Fangusaro, TJ MacDonald, XN Li, C Hawkins, V Rajaram, V Gopalakrishnan 22/01/2019