William Dynan, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-4104
Email Address

wdynan@emory.edu

Biography

William S. Dynan, PhD is a professor in the Department of Radiation Oncology at Emory University School of Medicine and a Georgia Research Alliance Eminent Scholar. Dr. Dynan is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.

Education

Dr. Dynan received his PhD in Oncology from the University of Wisconsin-Madison. He completed postdoctoral training in Biochemistry at the University of California-Berkeley, where he was a Damon Runyon Cancer Research Foundation fellow and a Senior Fellow of the American Cancer Society (California Division).

Titles & Roles

Professor, Department of Radiation Oncology

Emory University School of Medicine

Research

Dr. Dynan's laboratory studies biological responses to radiation-induced DNA damage. Current work focuses on cosmic ray exposure, cancer risk and the development of medical countermeasures. The laboratory also studies exosomes, which are vesicles that are secreted by cells and tissues in response to radiation and other stressors. The work has translational applications in the fields of radiotherapy and cancer immunotherapy.

Publications

Dr. Dynan has authored over 100 scientific publications and is the editor-in-chief of NAR Cancer. He is on the editorial boards of Nucleic Acids Research and Scientific Reports.

Title/Journal	Authors	Publication Date
SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients. NAR cancer	W Daddacha, D Monroe, AJ Schlafstein, AE Withers, EB Thompson, D Danelia, NC Luong, F Sesay, SK Rath, ER Usoro, ME Essien, AT Jung, JG Jiang, J Hu, B Mahboubi, A Williams, JE Steinbeck, X Yang, ZS Buchwald, WS Dynan, JM Switchenko, B Kim, MK Khan, DL Jaye, DS Yu	01/03/2024
A Novel Inverse Algorithm To Solve the Integrated Optimization of Dose, Dose Rate, and Linear Energy Transfer of Proton FLASH Therapy With Sparse Filters. International journal of radiation oncology, biology, physics	N Harrison, M Kang, R Liu, S Charyyev, N Wahl, W Liu, J Zhou, KA Higgins, CB Simone, JD Bradley, WS Dynan, L Lin	16/12/2023
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining. Nucleic acids research	PE Head, P Kapoor-Vazirani, GP Nagaraju, H Zhang, SK Rath, NC Luong, R Haji-Seyed-Javadi, F Sesay, SY Wang, DM Duong, W Daddacha, EV Minten, B Song, D Danelia, X Liu, S Li, EA Ortlund, NT Seyfried, DM Smalley, Y Wang, X Deng, WS Dynan, B El-Rayes, AJ Davis, DS Yu	25/08/2023
An Integrated Physical Optimization Framework for Proton Stereotactic Body Radiation Therapy FLASH Treatment Planning Allows Dose, Dose Rate, and Linear Energy Transfer Optimization Using Patient-Specific Ridge Filters. International journal of radiation oncology, biology, physics	R Liu, S Charyyev, N Wahl, W Liu, M Kang, J Zhou, X Yang, F Baltazar, M Palkowitsch, K Higgins, W Dynan, J Bradley, L Lin	15/07/2023
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates. Physics in medicine and biology	S Charyyev, R Liu, X Yang, J Zhou, A Dhabaan, WS Dynan, C Oancea, L Lin	12/07/2023
Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight. Life sciences in space research	WS Dynan, PY Chang, BJ Sishc, SR Elgart	01/11/2022
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery. Life sciences in space research	NE Hertel, SR Biegalski, VI Nelson, WA Nelson, S Mukhopadhyay, Z Su, AM Chan, AH Kesarwala, WS Dynan	01/11/2022
Editorial: NAR Cancer and epigenetics and cancer. NAR cancer	D Yang, J Dickerhoff, WS Dynan	01/03/2022
Characterization of exosome release and extracellular vesicle-associated miRNAs for human bronchial epithelial cells irradiated with high charge and energy ions. Life sciences in space research	Z Li, KK Jella, L Jaafar, CS Moreno, WS Dynan	01/02/2021
Exosome-Containing Preparations From Postirradiated Mouse Melanoma Cells Delay Melanoma Growth In Vivo by a Natural Killer Cell-Dependent Mechanism. International journal of radiation oncology, biology, physics	KK Jella, TH Nasti, Z Li, DH Lawson, JM Switchenko, R Ahmed, WS Dynan, MK Khan	01/09/2020
Withdrawal: Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. The Journal of biological chemistry	H Wang, X Wang, G Chen, X Zhang, X Tang, D Park, FA Cucinotta, DS Yu, X Deng, WS Dynan, PW Doetsch, Y Wang	01/05/2020
Editorial: Ribosome survey and summary collection 2020. Nucleic acids research	CM Dunham, WS Dynan, A Mankin	20/02/2020
Platforms for delivery of macromolecules to sites of DNA double-strand break repair. Artificial cells, nanomedicine, and biotechnology	Z Cao, D Goyal, SE Meiler, Y Zhou, WS Dynan	01/12/2019
Editorial: Introducing NAR Cancer. NAR cancer	WS Dynan	01/12/2019
Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells. Scientific reports	Z Li, KK Jella, L Jaafar, S Li, S Park, MD Story, H Wang, Y Wang, WS Dynan	23/07/2018
Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic acids research	KL Limpose, KS Trego, Z Li, SW Leung, AH Sarker, JA Shah, SS Ramalingam, EM Werner, WS Dynan, PK Cooper, AH Corbett, PW Doetsch	18/05/2018
Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer. Scientific reports	EM Kennedy, DR Powell, Z Li, JSK Bell, BG Barwick, H Feng, MR McCrary, B Dwivedi, J Kowalski, WS Dynan, KN Conneely, PM Vertino	30/04/2018
Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics. Nucleic acids research	BL Stoddard, A Khvorova, DR Corey, WS Dynan, KR Fox	28/02/2018
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell reports	W Daddacha, AE Koyen, AJ Bastien, PE Head, VR Dhere, GN Nabeta, EC Connolly, E Werner, MZ Madden, MB Daly, EV Minten, DR Whelan, AJ Schlafstein, H Zhang, R Anand, C Doronio, AE Withers, C Shepard, RK Sundaram, X Deng, WS Dynan, Y Wang, RS Bindra, P Cejka, E Rothenberg, PW Doetsch, B Kim, DS Yu	22/08/2017
Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes. DNA repair	S Li, FJ Shu, Z Li, L Jaafar, S Zhao, WS Dynan	01/03/2017
SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Nucleic acids research	L Jaafar, Z Li, S Li, WS Dynan	28/02/2017
Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life sciences in space research	DM Sridharan, A Asaithamby, SR Blattnig, SV Costes, PW Doetsch, WS Dynan, P Hahnfeldt, L Hlatky, Y Kidane, A Kronenberg, MD Naidu, LE Peterson, I Plante, AL Ponomarev, J Saha, AM Snijders, K Srinivasan, J Tang, E Werner, JM Pluth	01/06/2016
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell reports	H Zhang, PE Head, W Daddacha, SH Park, X Li, Y Pan, MZ Madden, DM Duong, M Xie, B Yu, MD Warren, EA Liu, VR Dhere, C Li, I Pradilla, MA Torres, Y Wang, WS Dynan, PW Doetsch, X Deng, NT Seyfried, D Gius, DS Yu	16/02/2016
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC cancer	HM Zhou, YY Fang, PM Weinberger, LL Ding, JK Cowell, FZ Hudson, M Ren, JR Lee, QK Chen, H Su, WS Dynan, Y Lin	04/02/2016
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory. Life sciences in space research	JW Norbury, W Schimmerling, TC Slaba, EI Azzam, FF Badavi, G Baiocco, E Benton, V Bindi, EA Blakely, SR Blattnig, DA Boothman, TB Borak, RA Britten, S Curtis, M Dingfelder, M Durante, WS Dynan, AJ Eisch, S Robin Elgart, DT Goodhead, PM Guida, LH Heilbronn, CE Hellweg, JL Huff, A Kronenberg, C La Tessa, DI Lowenstein, J Miller, T Morita, L Narici, GA Nelson, RB Norman, A Ottolenghi, ZS Patel, G Reitz, A Rusek, AS Schreurs, LA Scott-Carnell, E Semones, JW Shay, VA Shurshakov, L Sihver, LC Simonsen, MD Story, MS Turker, Y Uchihori, J Williams, CJ Zeitlin	01/02/2016
Co-culturing with High-Charge and Energy Particle Irradiated Cells Increases Mutagenic Joining of Enzymatically Induced DNA Double-Strand Breaks in Nonirradiated Cells. Radiation research	Z Li, G Doho, X Zheng, KK Jella, S Li, Y Wang, WS Dynan	01/09/2015
Characterization of DNA binding and pairing activities associated with the native SFPQ·NONO DNA repair protein complex. Biochemical and biophysical research communications	D Udayakumar, WS Dynan	07/08/2015
Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation. Radiation research	DM Sridharan, A Asaithamby, SM Bailey, SV Costes, PW Doetsch, WS Dynan, A Kronenberg, KN Rithidech, J Saha, AM Snijders, E Werner, C Wiese, FA Cucinotta, JM Pluth	01/01/2015
Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiation research	Z Li, H Wang, Y Wang, JP Murnane, WS Dynan	01/11/2014
Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog. Nucleic acids research	S Li, Z Li, FJ Shu, H Xiong, AC Phillips, WS Dynan	01/09/2014
Editorial: NAR surveys the past, present and future of restriction endonucleases. Nucleic acids research	W Dynan, K Fox, B Stoddard	01/01/2014
Synergistic effect of high charge and energy particle radiation and chronological age on biomarkers of oxidative stress and tissue degeneration: a ground-based study using the vertebrate laboratory model organism Oryzias latipes. PloS one	X Zheng, X Zhang, L Ding, JR Lee, PM Weinberger, WS Dynan	01/01/2014
Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic acids research	Z Chen, L Jaafar, DG Agyekum, H Xiao, MF Wade, RI Kumaran, DL Spector, G Bao, MH Porteus, WS Dynan, SE Meiler	01/10/2013
Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiation research	Z Li, FZ Hudson, H Wang, Y Wang, Z Bian, JP Murnane, WS Dynan	01/07/2013
Long-term effects of ionizing radiation on gene expression in a zebrafish model. PloS one	L Jaafar, RH Podolsky, WS Dynan	01/01/2013
Effects of low-dose ionizing radiation and menadione, an inducer of oxidative stress, alone and in combination in a vertebrate embryo model. Radiation research	CL Bladen, DJ Kozlowski, WS Dynan	01/11/2012
Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit. International journal of radiation oncology, biology, physics	H Xiong, RJ Lee, EB Haura, JG Edwards, WS Dynan, S Li	01/07/2012
Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells. DNA repair	K Ha, Y Takeda, WS Dynan	07/03/2011
Quantifiable biomarkers of normal aging in the Japanese medaka fish (Oryzias latipes). PloS one	L Ding, WW Kuhne, DE Hinton, J Song, WS Dynan	11/10/2010
Use of a microscope stage-mounted Nickel-63 microirradiator for real-time observation of the DNA double-strand break response. Nucleic acids research	Z Cao, WW Kuhne, J Steeb, MA Merkley, Y Zhou, J Janata, WS Dynan	01/08/2010
Human papillomavirus-active head and neck cancer and ethnic health disparities. The Laryngoscope	PM Weinberger, MA Merkley, SS Khichi, JR Lee, A Psyrri, LL Jackson, WS Dynan	01/08/2010
Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications. Nanomedicine : nanotechnology, biology, and medicine	S Li, L Nguyen, H Xiong, M Wang, TC Hu, JX She, SM Serkiz, GG Wicks, WS Dynan	01/02/2010
Multi-spectral imaging analysis of HSPB1 expression in head and neck squamous cell carcinoma. The Laryngoscope	JA Norton, PM Weinberger, MA Merkley, SS Khichi, LL Jackson, WS Dynan	01/01/2010
Significance of HSPB1 expression in head and neck squamous cell carcinoma: a meta-analysis of published literatures. The Laryngoscope	JA Norton, PM Weinberger, JL Waller, MA Merkley, LL Jackson, WS Dynan	01/01/2010
Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance. Nucleic acids research	S Li, WW Kuhne, A Kulharya, FZ Hudson, K Ha, Z Cao, WS Dynan	01/11/2009
2D-DIGE proteomic characterization of head and neck squamous cell carcinoma. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery	MA Merkley, PM Weinberger, LL Jackson, RH Podolsky, JR Lee, WS Dynan	01/11/2009
Biological effects of high-energy neutrons measured in vivo using a vertebrate model. Radiation research	WW Kuhne, BB Gersey, R Wilkins, H Wu, SA Wender, V George, WS Dynan	01/10/2009
Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer. Neoplasia (New York, N.Y.)	Y Lin, PJ Buckhaults, JR Lee, H Xiong, C Farrell, RH Podolsky, RR Schade, WS Dynan	01/09/2009
Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes. Proteome science	MA Merkley, E Hildebrandt, RH Podolsky, H Arnouk, DG Ferris, WS Dynan, H Stöppler	23/08/2009
E. coli expression of a soluble, active single-chain antibody variable fragment containing a nuclear localization signal. Protein expression and purification	H Xiong, S Li, Z Yang, RR Burgess, WS Dynan	01/08/2009
Use of combination proteomic analysis to demonstrate molecular similarity of head and neck squamous cell carcinoma arising from different subsites. Archives of otolaryngology--head & neck surgery	PM Weinberger, M Merkley, JR Lee, BL Adam, CG Gourin, RH Podolsky, BG Haffty, E Papadavid, C Sasaki, A Psyrri, WS Dynan	01/07/2009
Characterization of Molecular Markers Indicative of Cervical Cancer Progression. Proteomics. Clinical applications	H Arnouk, MA Merkley, RH Podolsky, H Stöppler, C Santos, M Alvarez, J Mariategui, D Ferris, JR Lee, WS Dynan	05/05/2009
The current state of proteomics in GI oncology. Digestive diseases and sciences	Y Lin, WS Dynan, JR Lee, ZH Zhu, RR Schade	01/03/2009
Understanding and re-engineering nucleoprotein machines to cure human disease. Nanomedicine (London, England)	W Dynan, Y Takeda, D Roth, G Bao	01/02/2008