Deborah DeRyckere, PhD
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Research Program
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Email Address
Deborah DeRyckere, is an assistant professor in the Department of Pediatrics at Emory University School of Medicine. Dr. DeRyckere is a pedriatic cancer researcher at Children's Healthcare of Atlanta. Prior to joining the faculty at Emory, she was on the faculty of the Department of Pediatrics at the University of Colorado School of Medicine.
Dr. DeRyckere is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.
Dr. DeRyckere earned her PhD in Molecular and Cell Biology from University of California-Berkeley.
Dr. DeRyckere's research focuses on the TAM-family of tyrosine kinases and their roles in tumorigenesis. More specifically, she has been working to validate MerTK as a therapeutic target in a variety of cancers and to develop novel biologic and small molecule MerTK and/or Axl inhibitors with the end goal of clinical application in patients with leukemia, non-small cell lung cancer, melanoma, or glioblastoma. More recently, she has focused on the role of MerTK in the immune system where it functions to suppress anti-tumor immunity.
Title/Journal | Authors | Publication Date |
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Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. Journal of medicinal chemistry |
D Kong, Q Tian, Z Chen, H Zheng, MA Stashko, D Yan, HS Earp, SV Frye, D DeRyckere, D Kireev, DK Graham, X Wang | 11/04/2024 |
TAM family kinases as therapeutic targets at the interface of cancer and immunity. Nature reviews. Clinical oncology |
D DeRyckere, JM Huelse, HS Earp, DK Graham | 01/11/2023 |
Genome medicine |
HL Mumme, SS Raikar, SS Bhasin, BE Thomas, T Lawrence, EP Weinzierl, Y Pang, D DeRyckere, C Gawad, DS Wechsler, CC Porter, SM Castellino, DK Graham, M Bhasin | 16/10/2023 |
Nature communications |
H Mumme, BE Thomas, SS Bhasin, U Krishnan, B Dwivedi, P Perumalla, D Sarkar, GB Ulukaya, HS Sabnis, SI Park, D DeRyckere, SS Raikar, M Pauly, RJ Summers, SM Castellino, DS Wechsler, CC Porter, DK Graham, M Bhasin | 05/10/2023 |
Journal of controlled release : official journal of the Controlled Release Society |
JM Kelvin, ML Chimenti, DY Zhang, EK Williams, SG Moore, GM Humber, TA Baxter, LA Birnbaum, M Qui, H Zecca, A Thapa, J Jain, NT Jui, X Wang, H Fu, Y Du, ML Kemp, WA Lam, DK Graham, D DeRyckere, EC Dreaden | 01/09/2023 |
Pharmaceutical research |
JM Kelvin, J Jain, A Thapa, M Qui, LA Birnbaum, SG Moore, H Zecca, RJ Summers, JM Switchenko, E Costanza, B Uricoli, X Wang, NT Jui, H Fu, Y Du, D DeRyckere, DK Graham, EC Dreaden | 01/09/2023 |
Scientific reports |
SS Bhasin, BE Thomas, RJ Summers, D Sarkar, H Mumme, W Pilcher, M Emam, SS Raikar, SI Park, SM Castellino, DK Graham, MK Bhasin, D DeRyckere | 02/08/2023 |
Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia. Cancer research communications |
CE Pillsbury, J Dougan, JL Rabe, JA Fonseca, C Zhou, AN Evans, H Abukharma, O Ichoku, G Gonzalez-Flamenco, SI Park, A Aljudi, D DeRyckere, SM Castellino, S Rafiq, S Langermann, LN Liu, CJ Henry, CC Porter | 01/07/2023 |
bioRxiv : the preprint server for biology |
JM Kelvin, J Jain, A Thapa, M Qui, LA Birnbaum, SG Moore, H Zecca, RJ Summers, E Costanza, B Uricoli, X Wang, NT Jui, H Fu, Y Du, D DeRyckere, DK Graham, EC Dreaden | 15/03/2023 |
Bioinformatics advances |
MH Ferrato, AG Marsh, KR Franke, BJ Huang, EA Kolb, D DeRyckere, DK Grahm, S Chandrasekaran, EL Crowgey | 01/01/2023 |
Cancers |
RJ Summers, J Jain, E Vasileiadi, B Smith, ML Chimenti, TY Yeung, J Kelvin, X Wang, SV Frye, HS Earp, JW Tyner, EC Dreaden, D DeRyckere, DK Graham | 13/12/2022 |
MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer. The Journal of clinical investigation |
D Yan, JM Huelse, D Kireev, Z Tan, L Chen, S Goyal, X Wang, SV Frye, M Behera, F Schneider, SS Ramalingam, T Owonikoko, HS Earp, D DeRyckere, DK Graham | 01/08/2022 |
Journal for immunotherapy of cancer |
JR Gilbert, HS Sabnis, R Radzievski, DB Doxie, D DeRyckere, SM Castellino, K Dhodapkar | 01/06/2022 |
Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nature communications |
M Lee, JAG Hamilton, GR Talekar, AJ Ross, L Michael, M Rupji, B Dwivedi, SS Raikar, J Boss, CD Scharer, DK Graham, D DeRyckere, CC Porter, CJ Henry | 03/03/2022 |
Advanced materials (Deerfield Beach, Fla.) |
MJ O'Melia, A Mulero-Russe, J Kim, A Pybus, D DeRyckere, L Wood, DK Graham, E Botchwey, AJ García, SN Thomas | 01/03/2022 |
Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer. Cancers |
D Yan, HS Earp, D DeRyckere, DK Graham | 11/11/2021 |
Pharmacology & therapeutics |
JM Huelse, DM Fridlyand, S Earp, D DeRyckere, DK Graham | 01/09/2021 |
UNC5293, a potent, orally available and highly MERTK-selective inhibitor. European journal of medicinal chemistry |
H Zheng, J Zhao, B Li, W Zhang, MA Stashko, KA Minson, MG Huey, Y Zhou, HS Earp, D Kireev, DK Graham, D DeRyckere, SV Frye, X Wang | 05/08/2021 |
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity. JCI insight |
AB Lee-Sherick, KM Jacobsen, CJ Henry, MG Huey, RE Parker, LS Page, AA Hill, X Wang, SV Frye, HS Earp, CT Jordan, D DeRyckere, DK Graham | 03/12/2020 |
Pharmacology & therapeutics |
JM Huelse, DM Fridlyand, S Earp, D DeRyckere, DK Graham | 01/09/2020 |
Risk-associated alterations in marrow T cells in pediatric leukemia. JCI insight |
JK Bailur, SS McCachren, K Pendleton, JC Vasquez, HS Lim, A Duffy, DB Doxie, A Kaushal, C Foster, D DeRyckere, S Castellino, ML Kemp, P Qiu, MV Dhodapkar, KM Dhodapkar | 20/08/2020 |
BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene |
AL Green, J DeSisto, P Flannery, R Lemma, A Knox, M Lemieux, B Sanford, R O'Rourke, S Ramkissoon, K Jones, J Perry, X Hui, E Moroze, I Balakrishnan, AF O'Neill, K Dunn, D DeRyckere, E Danis, A Safadi, A Gilani, B Hubbell-Engler, Z Nuss, JMM Levy, N Serkova, S Venkataraman, DK Graham, N Foreman, K Ligon, K Jones, AL Kung, R Vibhakar | 01/03/2020 |
Correction: BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene |
AL Green, J DeSisto, P Flannery, R Lemma, A Knox, M Lemieux, B Sanford, R O'Rourke, S Ramkissoon, K Jones, J Perry, X Hui, E Moroze, I Balakrishnan, AF O'Neill, K Dunn, D DeRyckere, E Danis, A Safadi, A Gilani, B Hubbell-Engler, Z Nuss, JMM Levy, N Serkova, S Venkataraman, DK Graham, N Foreman, K Ligon, K Jones, AL Kung, R Vibhakar | 01/03/2020 |
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. Journal of the American Chemical Society |
C Da, D Zhang, M Stashko, E Vasileiadi, RE Parker, KA Minson, MG Huey, JM Huelse, D Hunter, TSK Gilbert, J Norris-Drouin, M Miley, LE Herring, LM Graves, D DeRyckere, HS Earp, DK Graham, SV Frye, X Wang, D Kireev | 02/10/2019 |
Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma. Molecular cancer therapeutics |
L Sinik, KA Minson, JJ Tentler, J Carrico, SM Bagby, WA Robinson, R Kami, T Burstyn-Cohen, SG Eckhardt, X Wang, SV Frye, HS Earp, D DeRyckere, DK Graham | 01/02/2019 |
Clinical cancer research : an official journal of the American Association for Cancer Research |
D Yan, RE Parker, X Wang, SV Frye, HS Earp, D DeRyckere, DK Graham | 15/12/2018 |
The Emerging Role of TYRO3 as a Therapeutic Target in Cancer. Cancers |
SK Smart, E Vasileiadi, X Wang, D DeRyckere, DK Graham | 29/11/2018 |
Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. Journal of medicinal chemistry |
J Zhao, D Zhang, W Zhang, MA Stashko, D DeRyckere, E Vasileiadi, RE Parker, D Hunter, Q Liu, Y Zhang, J Norris-Drouin, B Li, DH Drewry, D Kireev, DK Graham, HS Earp, SV Frye, X Wang | 21/11/2018 |
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity. JCI insight |
AB Lee-Sherick, KM Jacobsen, CJ Henry, MG Huey, RE Parker, LS Page, AA Hill, X Wang, SV Frye, HS Earp, CT Jordan, D DeRyckere, DK Graham | 02/11/2018 |
MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents. Molecular cancer therapeutics |
NK McDaniel, CT Cummings, M Iida, J Hülse, HE Pearson, E Vasileiadi, RE Parker, RA Orbuch, OJ Ondracek, NB Welke, GH Kang, KD Davies, X Wang, SV Frye, HS Earp, PM Harari, RJ Kimple, D DeRyckere, DK Graham, DL Wheeler | 01/11/2018 |
The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. Journal of thrombosis and haemostasis : JTH |
BR Branchford, TJ Stalker, L Law, G Acevedo, S Sather, C Brzezinski, KM Wilson, K Minson, AB Lee-Sherick, P Davizon-Castillo, C Ng, W Zhang, KB Neeves, SR Lentz, X Wang, SV Frye, H Shelton Earp, D DeRyckere, LF Brass, DK Graham, JA Di Paola | 01/02/2018 |
Clinical cancer research : an official journal of the American Association for Cancer Research |
D DeRyckere, AB Lee-Sherick, MG Huey, AA Hill, JW Tyner, KM Jacobsen, LS Page, GG Kirkpatrick, F Eryildiz, SA Montgomery, W Zhang, X Wang, SV Frye, HS Earp, DK Graham | 15/03/2017 |
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem |
AL McIver, W Zhang, Q Liu, X Jiang, MA Stashko, J Nichols, MJ Miley, J Norris-Drouin, M Machius, D DeRyckere, E Wood, DK Graham, HS Earp, D Kireev, SV Frye, X Wang | 03/02/2017 |
The Current State of FLT3 Inhibition in Acute Myeloid Leukemia - Pitfalls and Promises. Journal of cell signaling |
KA Minson, D DeRyckere, DK Graham | 01/01/2017 |
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS medicinal chemistry letters |
X Wang, J Liu, W Zhang, MA Stashko, J Nichols, MJ Miley, J Norris-Drouin, Z Chen, M Machius, D DeRyckere, E Wood, DK Graham, HS Earp, D Kireev, SV Frye | 08/12/2016 |
Targeting the TAM Receptors in Leukemia. Cancers |
MG Huey, KA Minson, HS Earp, D DeRyckere, DK Graham | 08/11/2016 |
JCI insight |
KA Minson, CC Smith, D DeRyckere, C Libbrecht, AB Lee-Sherick, MG Huey, EA Lasater, GD Kirkpatrick, MA Stashko, W Zhang, CT Jordan, D Kireev, X Wang, SV Frye, HS Earp, NP Shah, DK Graham | 01/03/2016 |
PloS one |
A Sufit, AB Lee-Sherick, D DeRyckere, M Rupji, B Dwivedi, M Varella-Garcia, AM Pierce, J Kowalski, X Wang, SV Frye, HS Earp, AK Keating, DK Graham | 01/01/2016 |
Molecular cancer therapeutics |
CT Cummings, W Zhang, KD Davies, GD Kirkpatrick, D Zhang, D DeRyckere, X Wang, SV Frye, HS Earp, DK Graham | 01/09/2015 |
Oncotarget |
AB Lee-Sherick, W Zhang, KK Menachof, AA Hill, S Rinella, G Kirkpatrick, LS Page, MA Stashko, CT Jordan, Q Wei, J Liu, D Zhang, D DeRyckere, X Wang, S Frye, HS Earp, DK Graham | 30/03/2015 |
Clinical cancer research : an official journal of the American Association for Cancer Research |
F Alvarez-Calderon, MA Gregory, C Pham-Danis, D DeRyckere, BM Stevens, V Zaberezhnyy, AA Hill, L Gemta, A Kumar, V Kumar, MF Wempe, DA Pollyea, CT Jordan, NJ Serkova, DK Graham, J DeGregori | 15/03/2015 |
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer. Nature reviews. Cancer |
DK Graham, D DeRyckere, KD Davies, HS Earp | 01/12/2014 |
Oncotarget |
CT Cummings, RM Linger, RA Cohen, S Sather, GD Kirkpatrick, KD Davies, D DeRyckere, HS Earp, DK Graham | 15/11/2014 |
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. Journal of medicinal chemistry |
W Zhang, D DeRyckere, D Hunter, J Liu, MA Stashko, KA Minson, CT Cummings, M Lee, TG Glaros, DL Newton, S Sather, D Zhang, D Kireev, WP Janzen, HS Earp, DK Graham, SV Frye, X Wang | 28/08/2014 |
Molecular cancer therapeutics |
S Christoph, D Deryckere, J Schlegel, JK Frazer, LA Batchelor, AY Trakhimets, S Sather, DM Hunter, CT Cummings, J Liu, C Yang, D Kireev, C Simpson, J Norris-Drouin, EA Hull-Ryde, WP Janzen, GL Johnson, X Wang, SV Frye, HS Earp, DK Graham | 01/11/2013 |
Pre-clinical evaluation of tyrosine kinase inhibitors for treatment of acute leukemia. Journal of visualized experiments : JoVE |
S Christoph, AB Lee-Sherick, S Sather, D DeRyckere, DK Graham | 18/09/2013 |
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. The Journal of clinical investigation |
J Schlegel, MJ Sambade, S Sather, SJ Moschos, AC Tan, A Winges, D DeRyckere, CC Carson, DG Trembath, JJ Tentler, SG Eckhardt, PF Kuan, RL Hamilton, LM Duncan, CR Miller, N Nikolaishvili-Feinberg, BR Midkiff, J Liu, W Zhang, C Yang, X Wang, SV Frye, HS Earp, JM Shields, DK Graham | 01/05/2013 |
ACS medicinal chemistry letters |
J Liu, C Yang, C Simpson, D Deryckere, A Van Deusen, MJ Miley, D Kireev, J Norris-Drouin, S Sather, D Hunter, VK Korboukh, HS Patel, WP Janzen, M Machius, GL Johnson, HS Earp, DK Graham, SV Frye, X Wang | 09/02/2012 |
PloS one |
J Migdall-Wilson, C Bates, J Schlegel, L Brandão, RM Linger, D DeRyckere, DK Graham | 01/01/2012 |