Xingming Deng, PhD
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Xingming Deng, MD, PhD, is a professor and the inaugural Chair in Cancer Biology in the Department of Radiation Oncology of Emory University School of Medicine. Dr. Deng is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia. Prior to joining Emory in 2009, he was an assistant professor in the Division of Hematology/Oncology of the Department of Medicine at the University of Florida.
Dr. Deng is an active member of the American Association for Cancer Research. He has been the recipient of 18 research grants, including Clinical Innovator Awards from Flight Attendant Medical Research Institute, NASA research grant and several R01 grants from NIH/NCI. He has served on several national and international grant review panels.
Dr. Deng teaches the advanced course for cancer biology to graduate students and medical residents. He has mentored a number of undergraduates, graduates, postdoctoral fellows, medical residents and junior faculty members at the University of Florida and Emory University. He currently serves as a course director in Advanced Graduate Cancer Biology Program at Emory's Laney Graduate School.
Dr. Deng received his MD/PhD at Hunan Medical University and Beijing Medical University in China. He completed his postdoctoral training in Molecular Biology at the University of Texas Medical Branch.
Dr. Deng's major research interests are to uncover cell death mechanisms, especially Bcl2 family, to investigate molecular and signaling mechanisms of DNA repair, DNA replication stress, genomic instability and carcinogenesis, to study signaling mechanisms of tumor invasion/metastasis, to develop novel small molecule anti-cancer agents and new therapeutic strategies for cancer therapy by targeting apoptosis and DNA repair signaling pathways, and to target novel signal mechanisms of PD-1 and PD-L1 for immunotherapy. Additionally, he is also studying environmental carcinogenesis, specifically mechanisms of tobacco smoke- or space radiation-induced DNA damage, genomic instability and carcinogenesis at the cellular, molecular and animal levels.
Grant Number | Title |
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1K12CA237806-01 | Emory Clinical Oncology Career Development Award K12 Program |
1P50CA217691-01A1 | Project 3: Targeting Bax signaling to overcome treatment resistance in NSCLC |
1R01CA255257-01A1 | Modulation of Mcl-1 for Treatment of Lung Cancer |
5K12CA237806-02 | Emory Clinical Oncology Career Development Award K12 Program |
5K12CA237806-03 | Emory Clinical Oncology Career Development Award K12 Program |
5P50CA217691-02 | Project 3: Targeting Bax signaling to overcome treatment resistance in NSCLC |
5P50CA217691-03 | Project 3: Targeting Bax signaling to overcome treatment resistance in NSCLC |
5P50CA217691-04 | Project 3: Targeting Bax signaling to overcome treatment resistance in NSCLC |
5R01CA255257-02 | Modulation of Mcl-1 for Treatment of Lung Cancer |
5R01CA255257-03 | Modulation of Mcl-1 for Treatment of Lung Cancer |
Deng has published many excellent research articles in high impact journals such as Molecular Cell, Cancer Cell, Nature Communications, The Journal of Clinical Investigation, PNAS, Cancer Research, Cell Death Differentiation, Nucleic Acid Research, MCB, Blood, and The Journal of Biological Chemistry among others. He serves on the editorial board for several journals and is frequently invited to serve as reviewer for numerous biomedical journals. He has also obtained three patents for new anticancer drug discovery.
Title/Journal | Authors | Publication Date |
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Nucleic acids research |
PE Head, P Kapoor-Vazirani, GP Nagaraju, H Zhang, SK Rath, NC Luong, R Haji-Seyed-Javadi, F Sesay, SY Wang, DM Duong, W Daddacha, EV Minten, B Song, D Danelia, X Liu, S Li, EA Ortlund, NT Seyfried, DM Smalley, Y Wang, X Deng, WS Dynan, B El-Rayes, AJ Davis, DS Yu | 25/08/2023 |
Nature communications |
P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu | 07/11/2022 |
Oncogene |
G Ma, Y Deng, L Qian, KA Vallega, G Zhang, X Deng, TK Owonikoko, SS Ramalingam, DD Fang, Y Zhai, SY Sun | 01/03/2022 |
Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy. Cancer biology & therapy |
MJ Kim, G Chen, GL Sica, X Deng | 02/01/2021 |
Discovery of Small Molecule Bak Activator for Lung Cancer Therapy. Theranostics |
D Park, ASM Anisuzzaman, AT Magis, G Chen, M Xie, G Zhang, M Behera, GL Sica, SS Ramalingam, TK Owonikoko, X Deng | 01/01/2021 |
Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation. Carcinogenesis |
M Xie, D Park, GL Sica, X Deng | 13/11/2020 |
Oncogene |
AE Koyen, MZ Madden, D Park, EV Minten, P Kapoor-Vazirani, E Werner, NT Pfister, R Haji-Seyed-Javadi, H Zhang, J Xu, N Deng, DM Duong, TJ Pecen, Z Frazier, ZD Nagel, JB Lazaro, KW Mouw, NT Seyfried, CS Moreno, TK Owonikoko, X Deng, DS Yu | 01/06/2020 |
Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. Molecular cancer |
K Xu, D Park, AT Magis, J Zhang, W Zhou, GL Sica, SS Ramalingam, WJ Curran, X Deng | 20/05/2020 |
The Journal of biological chemistry |
H Wang, X Wang, G Chen, X Zhang, X Tang, D Park, FA Cucinotta, DS Yu, X Deng, WS Dynan, PW Doetsch, Y Wang | 01/05/2020 |
Theranostics |
Y Li, B Zhang, L Xiang, S Xia, O Kucuk, X Deng, LH Boise, JT Dong | 01/01/2020 |
Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer research |
G Chen, D Park, AT Magis, M Behera, SS Ramalingam, TK Owonikoko, GL Sica, K Ye, C Zhang, Z Chen, WJ Curran, X Deng | 15/12/2019 |
Acetylation regulates ribonucleotide reductase activity and cancer cell growth. Nature communications |
G Chen, Y Luo, K Warncke, Y Sun, DS Yu, H Fu, M Behera, SS Ramalingam, PW Doetsch, DM Duong, M Lammers, WJ Curran, X Deng | 19/07/2019 |
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. Molecular cancer |
K Xu, D Park, AT Magis, J Zhang, W Zhou, GL Sica, SS Ramalingam, WJ Curran, X Deng | 10/04/2019 |
Cell Synchronization by Double Thymidine Block. Bio-protocol |
G Chen, X Deng | 05/09/2018 |
Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin. Clinical cancer research : an official journal of the American Association for Cancer Research |
X Wang, JJ Beitler, W Huang, G Chen, G Qian, K Magliocca, MR Patel, AY Chen, J Zhang, S Nannapaneni, S Kim, Z Chen, X Deng, NF Saba, ZG Chen, JL Arbiser, DM Shin | 15/02/2018 |
Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. The Journal of clinical investigation |
G Chen, AT Magis, K Xu, D Park, DS Yu, TK Owonikoko, GL Sica, SW Satola, SS Ramalingam, WJ Curran, PW Doetsch, X Deng | 02/01/2018 |
The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis. Molecular cancer research : MCR |
JJ Barrott, JF Zhu, K Smith-Fry, AM Susko, D Nollner, LD Burrell, A Pozner, MR Capecchi, JT Yap, LA Cannon-Albright, X Deng, KB Jones | 01/12/2017 |
Molecular therapy : the journal of the American Society of Gene Therapy |
W Liu, B Zhang, G Chen, W Wu, L Zhou, Y Shi, Q Zeng, Y Li, Y Sun, X Deng, F Wang | 06/09/2017 |
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell reports |
W Daddacha, AE Koyen, AJ Bastien, PE Head, VR Dhere, GN Nabeta, EC Connolly, E Werner, MZ Madden, MB Daly, EV Minten, DR Whelan, AJ Schlafstein, H Zhang, R Anand, C Doronio, AE Withers, C Shepard, RK Sundaram, X Deng, WS Dynan, Y Wang, RS Bindra, P Cejka, E Rothenberg, PW Doetsch, B Kim, DS Yu | 22/08/2017 |
Modulation of Bax and mTOR for Cancer Therapeutics. Cancer research |
R Li, C Ding, J Zhang, M Xie, D Park, Y Ding, G Chen, G Zhang, M Gilbert-Ross, W Zhou, AI Marcus, SY Sun, ZG Chen, GL Sica, SS Ramalingam, AT Magis, H Fu, FR Khuri, WJ Curran, TK Owonikoko, DM Shin, J Zhou, X Deng | 01/06/2017 |
Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion. Oncotarget |
LL Yang, BC Liu, XY Lu, Y Yan, YJ Zhai, Q Bao, PW Doetsch, X Deng, TL Thai, AA Alli, DC Eaton, BZ Shen, HP Ma | 17/01/2017 |
Establishment of Patient-derived Xenografts in Mice. Bio-protocol |
D Park, D Wang, G Chen, X Deng | 20/11/2016 |
Targeting DNA Replication Stress for Cancer Therapy. Genes |
J Zhang, Q Dai, D Park, X Deng | 19/08/2016 |
BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget |
J Deng, D Park, M Wang, A Nooka, Q Deng, S Matulis, J Kaufman, S Lonial, LH Boise, J Galipeau, X Deng | 10/05/2016 |
Journal of translational medicine |
TK Owonikoko, G Zhang, HS Kim, RM Stinson, R Bechara, C Zhang, Z Chen, NF Saba, S Pakkala, R Pillai, X Deng, SY Sun, MR Rossi, GL Sica, SS Ramalingam, FR Khuri | 03/05/2016 |
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell reports |
H Zhang, PE Head, W Daddacha, SH Park, X Li, Y Pan, MZ Madden, DM Duong, M Xie, B Yu, MD Warren, EA Liu, VR Dhere, C Li, I Pradilla, MA Torres, Y Wang, WS Dynan, PW Doetsch, X Deng, NT Seyfried, D Gius, DS Yu | 16/02/2016 |
Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities. Acta biochimica et biophysica Sinica |
J Zhang, D Park, DM Shin, X Deng | 01/01/2016 |
Bcl2 inhibition of mitochondrial DNA repair. BMC cancer |
M Xie, PW Doetsch, X Deng | 13/08/2015 |
Molecular and cellular biology |
J Koo, P Yue, X Deng, FR Khuri, SY Sun | 01/07/2015 |
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer cell |
B Han, D Park, R Li, M Xie, TK Owonikoko, G Zhang, GL Sica, C Ding, J Zhou, AT Magis, ZG Chen, DM Shin, SS Ramalingam, FR Khuri, WJ Curran, X Deng | 08/06/2015 |
Clinical cancer research : an official journal of the American Association for Cancer Research |
TK Owonikoko, SS Ramalingam, DL Miller, SD Force, GL Sica, J Mendel, Z Chen, A Rogatko, M Tighiouart, RD Harvey, S Kim, NF Saba, A Pickens, M Behera, RW Fu, MR Rossi, WF Auffermann, WE Torres, R Bechara, X Deng, SY Sun, H Fu, AA Gal, FR Khuri | 15/04/2015 |
Nucleic acids research |
M Xie, D Park, S You, R Li, TK Owonikoko, Y Wang, PW Doetsch, X Deng | 01/01/2015 |
Oncoscience |
G Chen, X Deng | 01/01/2015 |
Cancer medicine |
TK Owonikoko, G Zhang, X Deng, MR Rossi, JM Switchenko, GH Doho, Z Chen, S Kim, S Strychor, SM Christner, J Beumer, C Li, P Yue, A Chen, GL Sica, SS Ramalingam, J Kowalski, FR Khuri, SY Sun | 01/12/2014 |
Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer |
KA Higgins, D Park, GY Lee, WJ Curran, X Deng | 01/11/2014 |
Small-molecule Bax agonists for cancer therapy. Nature communications |
M Xin, R Li, M Xie, D Park, TK Owonikoko, GL Sica, PE Corsino, J Zhou, C Ding, MA White, AT Magis, SS Ramalingam, WJ Curran, FR Khuri, X Deng | 17/09/2014 |
Oncogene |
L Xiao, ZY Hu, X Dong, Z Tan, W Li, M Tang, L Chen, L Yang, Y Tao, Y Jiang, J Li, B Yi, B Li, S Fan, S You, X Deng, F Hu, L Feng, AM Bode, Z Dong, LQ Sun, Y Cao | 11/09/2014 |
Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis. Cell death and differentiation |
B Wang, M Xie, R Li, TK Owonikoko, SS Ramalingam, FR Khuri, WJ Curran, Y Wang, X Deng | 01/07/2014 |
Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Molecular cancer therapeutics |
S You, R Li, D Park, M Xie, GL Sica, Y Cao, ZQ Xiao, X Deng | 01/03/2014 |
Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase. Cancer research |
M Xie, Y Yen, TK Owonikoko, SS Ramalingam, FR Khuri, WJ Curran, PW Doetsch, X Deng | 01/01/2014 |
Altered glutamine metabolism and therapeutic opportunities for lung cancer. Clinical lung cancer |
A Mohamed, X Deng, FR Khuri, TK Owonikoko | 01/01/2014 |
Scientifica |
X Deng | 01/01/2014 |
Molecular cancer |
H Ren, J Koo, B Guan, P Yue, X Deng, M Chen, FR Khuri, SY Sun | 22/11/2013 |
International journal of oncology |
X Ma, Z Xu, L Yang, L Xiao, M Tang, J Lu, S Xu, Y Tang, X Wen, X Deng, L Sun, Y Cao | 01/11/2013 |
Molecular cancer therapeutics |
R Li, Z Hu, SY Sun, ZG Chen, TK Owonikoko, GL Sica, SS Ramalingam, WJ Curran, FR Khuri, X Deng | 01/10/2013 |
Cancer letters |
H Ren, L Zhao, Y Li, P Yue, X Deng, TK Owonikoko, M Chen, FR Khuri, SY Sun | 28/09/2013 |
Novel small-molecule inhibitors of Bcl-XL to treat lung cancer. Cancer research |
D Park, AT Magis, R Li, TK Owonikoko, GL Sica, SY Sun, SS Ramalingam, FR Khuri, WJ Curran, X Deng | 01/09/2013 |
Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis. Cell division |
KR Hagen, X Zeng, MY Lee, S Tucker Kahn, MK Harrison Pitner, SS Zaky, Y Liu, RM O'Regan, X Deng, HI Saavedra | 25/07/2013 |
RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research |
MA Rahman, AR Amin, D Wang, L Koenig, S Nannapaneni, Z Chen, Z Wang, G Sica, X Deng, ZG Chen, DM Shin | 01/07/2013 |
The Journal of biological chemistry |
Y Li, X Wang, P Yue, H Tao, SS Ramalingam, TK Owonikoko, X Deng, Y Wang, H Fu, FR Khuri, SY Sun | 10/05/2013 |
Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PloS one |
R Li, S You, Z Hu, ZG Chen, GL Sica, FR Khuri, WJ Curran, DM Shin, X Deng | 01/01/2013 |
PloS one |
GQ Zeng, H Yi, PF Zhang, XH Li, R Hu, MY Li, C Li, JQ Qu, X Deng, ZQ Xiao | 01/01/2013 |
c-Myc suppression of DNA double-strand break repair. Neoplasia (New York, N.Y.) |
Z Li, TK Owonikoko, SY Sun, SS Ramalingam, PW Doetsch, ZQ Xiao, FR Khuri, WJ Curran, X Deng | 01/12/2012 |
Molecular & cellular proteomics : MCP |
GQ Zeng, PF Zhang, X Deng, FL Yu, C Li, Y Xu, H Yi, MY Li, R Hu, JH Zuo, XH Li, XX Wan, JQ Qu, QY He, JH Li, X Ye, Y Chen, JY Li, ZQ Xiao | 01/06/2012 |
NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop. Cancer letters |
J Shen, L Xu, TK Owonikoko, SY Sun, FR Khuri, WJ Curran, X Deng | 01/05/2012 |
International journal of pharmaceutics |
J Duan, HM Mansour, Y Zhang, X Deng, Y Chen, J Wang, Y Pan, J Zhao | 15/04/2012 |
Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells. Molecular cancer therapeutics |
Y Liu, SY Sun, TK Owonikoko, GL Sica, WJ Curran, FR Khuri, X Deng | 01/01/2012 |
Molecular cancer |
M Liao, J Zhao, T Wang, J Duan, Y Zhang, X Deng | 20/04/2011 |
International journal of pharmaceutics |
J Duan, Y Zhang, S Han, Y Chen, B Li, M Liao, W Chen, X Deng, J Zhao, B Huang | 15/11/2010 |
Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax. PloS one |
Q Wang, SY Sun, F Khuri, WJ Curran, X Deng | 14/10/2010 |
Neoplasia (New York, N.Y.) |
Y Li, P Yue, X Deng, T Ueda, R Fukunaga, FR Khuri, SY Sun | 01/10/2010 |
Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation. The Journal of biological chemistry |
C Li, S Chen, P Yue, X Deng, S Lonial, FR Khuri, SY Sun | 21/05/2010 |
Nicotine enhances the antiapoptotic function of Mcl-1 through phosphorylation. Molecular cancer research : MCR |
J Zhao, M Xin, T Wang, Y Zhang, X Deng | 01/12/2009 |
Dr. Deng has received a number of awards in his career including AACR-Bristol-Myers Squibb Young Investigator Award, three ASH Travel Awards, Basic Science Research Winner, Excellence in Research Award, Emory University Winship Scholar and the Emory 1% Award with NIH R01 grant scoring in the top 1% at peer review.