Robert Craig Castellino, MD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-727-2078
Email Address

rccaste@emory.edu

Biography

Robert Craig Castellino, MD, is an associate professor in the Department of Pediatrics at Emory University School of Medicine. He is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.

Education

Dr. Castellino received his medical degree from Duke University, Durham, North Carolina. He completed his residency in pediatrics at Harvard Medical School and Massachusetts General Hospital in Boston, Massachussetts. He completed his fellowship in pediatric hematology and oncology at Texas Children's Cancer Center at Baylor College of Medicine in Houston.

Titles & Roles

Associate Professor, Department of Pediatrics

Emory University School of Medicine

Professional Memberships

Dr. Castellino is a member of the American Association for Cancer Research.

Research

Dr. Castellino's research focuses on PPM1D-mediated signaling pathways that divert normal brain development toward growth and dissemination of medulloblastoma or DIPG. His team uses in vitro assays, mouse models, and patient-derived tissues to understand signaling in growth, treatment resistance, and response to novel PPM1D-targeted therapies to improve survival and outcome in children.

View Current Clinical Trials


Phase I Location Winship Cancer Institute

Title/Journal	Authors	Publication Date
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial. Neuro-oncology	TS Johnson, TJ MacDonald, R Pacholczyk, D Aguilera, A Al-Basheer, M Bajaj, P Bandopadhayay, Z Berrong, E Bouffet, RC Castellino, K Dorris, BR Eaton, N Esiashvili, JR Fangusaro, N Foreman, D Fridlyand, C Giller, IM Heger, C Huang, N Kadom, EP Kennedy, N Manoharan, W Martin, C McDonough, RS Parker, V Ramaswamy, E Ring, A Rojiani, RF Sadek, S Satpathy, M Schniederjan, A Smith, C Smith, BE Thomas, R Vaizer, KK Yeo, MK Bhasin, DH Munn	02/02/2024
A Pilot Study Omitting Radiation in the Treatment of Children with Newly Diagnosed Wnt-Activated Medulloblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research	KJ Cohen, V Munjapara, D Aguilera, RC Castellino, SL Stapleton, D Landi, DM Ashley, FJ Rodriguez, C Hawkins, E Yang, W London, S Chi, P Bandopadhayay	15/12/2023
Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care. JCO precision oncology	RJ Summers, SM Castellino, CC Porter, TJ MacDonald, GD Basu, S Szelinger, MK Bhasin, T Cash, AB Carter, RC Castellino, JR Fangusaro, SG Mitchell, MG Pauly, B Pencheva, DS Wechsler, DK Graham, KC Goldsmith	01/04/2022
Synthetic extracellular matrices and astrocytes provide a supportive microenvironment for the cultivation and investigation of primary pediatric gliomas. Neuro-oncology advances	CM Rota, AT Brown, E Addleson, C Ives, E Trumper, K Pelton, WP Teh, MJ Schniederjan, RC Castellino, S Buhrlage, DA Lauffenburger, KL Ligon, LG Griffith, RA Segal	01/01/2022
Ten-eleven translocation protein 1 modulates medulloblastoma progression. Genome biology	H Kim, Y Kang, Y Li, L Chen, L Lin, ND Johnson, D Zhu, MH Robinson, L McSwain, BG Barwick, X Yuan, X Liao, J Zhao, Z Zhang, Q Shu, J Chen, EG Allen, AM Kenney, RC Castellino, EG Van Meir, KN Conneely, PM Vertino, P Jin, J Li	29/04/2021
Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in cancer. Biochemical pharmacology	R Nahta, RC Castellino	01/02/2021
Correction: Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling. Oncotarget	BF Peake, SM Eze, L Yang, RC Castellino, R Nahta	03/11/2020
Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma. Neuro-oncology	MP Akamandisa, K Nie, R Nahta, D Hambardzumyan, RC Castellino	10/06/2019
High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases. AJNR. American journal of neuroradiology	CD Spyris, RC Castellino, MJ Schniederjan, N Kadom	01/02/2019
Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum. Developmental cell	RC Castellino, AM Kenney	28/01/2019
Clinical responses of patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery	D Aguilera, RC Castellino, A Janss, M Schniederjan, R McNall, T MacDonald, C Mazewski	01/02/2018
Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling. Oncotarget	BF Peake, SM Eze, L Yang, RC Castellino, R Nahta	07/11/2017
WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Oncogene	J Wen, J Lee, A Malhotra, R Nahta, AR Arnold, MC Buss, BD Brown, C Maier, AM Kenney, M Remke, V Ramaswamy, MD Taylor, RC Castellino	20/10/2016
Successful Retreatment of a Child with a Refractory Brainstem Ganglioglioma with Vemurafenib. Pediatric blood & cancer	D Aguilera, A Janss, C Mazewski, RC Castellino, M Schniederjan, L Hayes, B Brahma, L Fogelgren, TJ MacDonald	01/03/2016
PPM1D/WIP1 in medulloblastoma. Oncoscience	MP Akamandisa, R Nahta, RC Castellino	01/01/2016
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis	WH Goodson, L Lowe, DO Carpenter, M Gilbertson, A Manaf Ali, A Lopez de Cerain Salsamendi, A Lasfar, A Carnero, A Azqueta, A Amedei, AK Charles, AR Collins, A Ward, AC Salzberg, A Colacci, AK Olsen, A Berg, BJ Barclay, BP Zhou, C Blanco-Aparicio, CJ Baglole, C Dong, C Mondello, CW Hsu, CC Naus, C Yedjou, CS Curran, DW Laird, DC Koch, DJ Carlin, DW Felsher, D Roy, DG Brown, E Ratovitski, EP Ryan, E Corsini, E Rojas, EY Moon, E Laconi, F Marongiu, F Al-Mulla, F Chiaradonna, F Darroudi, FL Martin, FJ Van Schooten, GS Goldberg, G Wagemaker, GN Nangami, GM Calaf, G Williams, GT Wolf, G Koppen, G Brunborg, HK Lyerly, H Krishnan, H Ab Hamid, H Yasaei, H Sone, H Kondoh, HK Salem, HY Hsu, HH Park, I Koturbash, IR Miousse, AI Scovassi, JE Klaunig, J Vondráček, J Raju, J Roman, JP Wise, JR Whitfield, J Woodrick, JA Christopher, J Ochieng, JF Martinez-Leal, J Weisz, J Kravchenko, J Sun, KR Prudhomme, KB Narayanan, KA Cohen-Solal, K Moorwood, L Gonzalez, L Soucek, L Jian, LS D'Abronzo, LT Lin, L Li, L Gulliver, LJ McCawley, L Memeo, L Vermeulen, L Leyns, L Zhang, M Valverde, M Khatami, MF Romano, M Chapellier, MA Williams, M Wade, MH Manjili, ME Lleonart, M Xia, MJ Gonzalez, MV Karamouzis, M Kirsch-Volders, M Vaccari, NB Kuemmerle, N Singh, N Cruickshanks, N Kleinstreuer, N van Larebeke, N Ahmed, O Ogunkua, PK Krishnakumar, P Vadgama, PA Marignani, PM Ghosh, P Ostrosky-Wegman, PA Thompson, P Dent, P Heneberg, P Darbre, P Sing Leung, P Nangia-Makker, QS Cheng, RB Robey, R Al-Temaimi, R Roy, R Andrade-Vieira, RK Sinha, R Mehta, R Vento, R Di Fiore, R Ponce-Cusi, R Dornetshuber-Fleiss, R Nahta, RC Castellino, R Palorini, R Abd Hamid, SA Langie, SE Eltom, SA Brooks, S Ryeom, SS Wise, SN Bay, SA Harris, S Papagerakis, S Romano, S Pavanello, S Eriksson, S Forte, SC Casey, S Luanpitpong, TJ Lee, T Otsuki, T Chen, T Massfelder, T Sanderson, T Guarnieri, T Hultman, V Dormoy, V Odero-Marah, V Sabbisetti, V Maguer-Satta, WK Rathmell, W Engström, WK Decker, WH Bisson, Y Rojanasakul, Y Luqmani, Z Chen, Z Hu	01/06/2015
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis	R Nahta, F Al-Mulla, R Al-Temaimi, A Amedei, R Andrade-Vieira, SN Bay, DG Brown, GM Calaf, RC Castellino, KA Cohen-Solal, A Colacci, N Cruickshanks, P Dent, R Di Fiore, S Forte, GS Goldberg, RA Hamid, H Krishnan, DW Laird, A Lasfar, PA Marignani, L Memeo, C Mondello, CC Naus, R Ponce-Cusi, J Raju, D Roy, R Roy, EP Ryan, HK Salem, AI Scovassi, N Singh, M Vaccari, R Vento, J Vondráček, M Wade, J Woodrick, WH Bisson	01/06/2015
The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants. Oncogene	MC Buss, M Remke, J Lee, K Gandhi, MJ Schniederjan, M Kool, PA Northcott, SM Pfister, MD Taylor, RC Castellino	26/02/2015
Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1. Molecular pharmacology	E Sanabria-Figueroa, SM Donnelly, KC Foy, MC Buss, RC Castellino, E Paplomata, L Taliaferro-Smith, PT Kaumaya, R Nahta	01/02/2015
Response of subependymal giant cell astrocytoma with spinal cord metastasis to everolimus. Journal of pediatric hematology/oncology	D Aguilera, R Flamini, C Mazewski, M Schniederjan, L Hayes, W Boydston, RC Castellino, TJ MacDonald	01/10/2014
The rationale for targeted therapies in medulloblastoma. Neuro-oncology	TJ MacDonald, D Aguilera, RC Castellino	01/01/2014
Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery	D Aguilera, C Mazewski, J Fangusaro, TJ MacDonald, RY McNall-Knapp, LL Hayes, S Kim, RC Castellino	01/04/2013
MEK inhibition increases lapatinib sensitivity via modulation of FOXM1. Current medicinal chemistry	SS Gayle, RC Castellino, MC Buss, R Nahta	01/01/2013
HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro-oncology	MC Buss, TA Read, MJ Schniederjan, K Gandhi, RC Castellino	01/04/2012
A MCP1 fusokine with CCR2-specific tumoricidal activity. Molecular cancer	M Rafei, J Deng, MN Boivin, P Williams, SM Matulis, S Yuan, E Birman, K Forner, L Yuan, C Castellino, LH Boise, TJ MacDonald, J Galipeau	24/09/2011
Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells. Journal of neuro-oncology	TJ Abouantoun, RC Castellino, TJ MacDonald	01/01/2011
Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PloS one	RC Castellino, BG Barwick, M Schniederjan, MC Buss, O Becher, D Hambardzumyan, TJ Macdonald, DJ Brat, DL Durden	26/05/2010
PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. Current pharmaceutical design	RC Castellino, CR Muh, DL Durden	01/01/2009

Awards

Dr. Castellino has been the recipient of numerous awards. He was named a Duke Futures Scholar and received a North Carolina Scholars Scholarship, General Motors Full-Tuition Scholarship, Hillory M. Wilder Endowed Scholarship, and Medical School Faculty Wives Club Endowed Scholarship. He completed the Charles Stark Draper Fellowship in Aeronautics at M.I.T. in 1993 and the Medical Student Summer Fellowship at Duke University in 1998.

Dr. Castellino is or has been the recipient of the NIH T32 Pediatric Training Award, the Stephanie Kramer/American Brain Tumor Association Translational Brain Tumor Research Grant, the NIH Molecular Medicine Scholar Award, Alex's Lemonade Stand Foundation Young Investigator Award, the Bear Necessities Pediatric Cancer Foundation, Junior Investigator Award, the AACR-Aflac, Inc. Career Development Award for Pediatric Cancer Research, the CURE Childhood Cancer Foundation Research Award, the St. Baldrick's Foundation Career Development (Scholar) Award, the Emory Egleston Children's Research Center Seed Grant, Winship Cancer Institute Molecular Pathways and Biomarkers Program Seed Grant, Southeastern Brain Tumor Foundation Research Grant, the Scholar Award-Competitive Extension from St. Baldrick's Foundation, the Pediatric Research Center for Neuroscience Pilot Grant and the Alex's Lemonade Stand Foundation Springboard Grant.

Dr. Castellino was also featured on CNN Health Update as a St. Baldrick's Foundation Scholar in 2009 and received an NIH/NCI R01 for Mechanisms of PPM1D in medulloblastoma tumorigenesis and invasion at Emory University for 2013-2018.