Jeremy Boss, PhD
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Research Program
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Phone Number
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Email Address
Jeremy M. Boss, PhD, is Professor and Chair of the Department of Microbiology and Immunology at Emory University School of Medicine in Atlanta, Georgia. Dr. Boss is the Emory Chair in Basic Sciences Research and also serves as associate dean of basic research at Emory University School of Medicine. He is a member of the Cancer Immunology Research Program at Winship Cancer Institute.
Dr. Boss received his PhD in Molecular Biology from the State University of New York in Albany, NY. He completed his postdoctoral training in Immunology at Harvard University in Cambridge, MA.
Dr. Boss uses genetic, biochemical, immunological, and molecular biological technologies to unravel the mechanisms by which immune system genes are regulated. Several systems are studied. The first focuses is on the major histocompatibility complex class II (MHC-II) genes, which are responsible for the presentation of foreign antigens to T lymphocytes. Proper tissue specific regulation of MHC-II genes is essential for the control and development of immune-based responses to pathogens and protecting from cancer and autoimmune disorders. His lab's studies examine the role that modifiers of chromatin structure play in organizing the architecture and expression of MHC-II genes.
Recently, his lab found that interactions between transcriptional insulators and gene promoters form a unique architecture within the nucleus of each cell that is critical to expression of the gene system. Identification of the factors that control this architecture is a current thrust of the work as these are potential targets to manipulate immune responses and improve the efficacy of vaccination protocols.
The second involves studies that focus on the molecular regulation of programmed cell death-1 (PD-1) during viral infection and cancer. PD-1 expression controls the ability of T cells to function and remove virus-infected cells or cancer cells. PD-1 is regulated by a complex set of transcription factors that activate or repress the expression. Manipulating these factors leads to prolonged PD-1 expression and failure to clear tumors or fight infection.
Third, his lab is also determining the epigenetic mechanisms that control lymphocyte cell fate using mouse models of infection as well as studies examining B cells associated with systemic lupus erythematosus (SLE). These studies are expected to lead to novel therapeutic targets to help improve vaccination and cancer therapies and treat autoimmune diseases.
Grant Number | Title |
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1R01AI153102-01 | Role of the DR/DQ super enhancer in MHC-II expression |
2R01AI113021-06A1 | Regulation of Human PD-1 Gene Expression |
5R01AI113021-07 | Regulation of Human PD-1 Gene Expression |
5R01AI113021-08 | Regulation of Human PD-1 Gene Expression |
5R01AI113021-09 | Regulation of Human PD-1 Gene Expression |
5R01AI153102-02 | Role of the DR/DQ super enhancer in MHC-II expression |
5R01AI153102-03 | Role of the DR/DQ super enhancer in MHC-II expression |
5R01AI153102-04 | Role of the DR/DQ super enhancer in MHC-II expression |
Title/Journal | Authors | Publication Date |
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Exploration of potential immune mechanisms in cervical dystonia. Parkinsonism & related disorders |
LM Scorr, G Kilic-Berkmen, DJ Sutcliffe, AR Dinasarapu, JL McKay, P Bagchi, MD Powell, JM Boss, N Cereb, M Little, L Gragert, J Hanfelt, A McKeon, W Tyor, HA Jinnah | 17/02/2024 |
Prevention of respiratory virus transmission by resident memory CD8+ T cells. Nature |
I Uddbäck, SE Michalets, A Saha, C Mattingly, KN Kost, ME Williams, LA Lawrence, SL Hicks, AC Lowen, H Ahmed, AR Thomsen, CJ Russell, CD Scharer, JM Boss, K Koelle, R Antia, JP Christensen, JE Kohlmeier | 01/02/2024 |
CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation. Heliyon |
Z Zuo, AK Kania, DG Patterson, SL Hicks, J Maurer, M Gupta, JM Boss, CD Scharer | 01/06/2023 |
The 'omics of obesity in B-cell acute lymphoblastic leukemia. Journal of the National Cancer Institute. Monographs |
DK Geitgey, M Lee, KA Cottrill, M Jaffe, W Pilcher, S Bhasin, J Randall, AJ Ross, M Salemi, M Castillo-Castrejon, MB Kilgore, AC Brown, JM Boss, R Johnston, AM Fitzpatrick, ML Kemp, R English, E Weaver, P Bagchi, R Walsh, CD Scharer, M Bhasin, JD Chandler, KA Haynes, EA Wellberg, CJ Henry | 04/05/2023 |
Immunity |
A Nellore, E Zumaquero, CD Scharer, CF Fucile, CM Tipton, RG King, T Mi, B Mousseau, JE Bradley, F Zhou, S Mutneja, PA Goepfert, JM Boss, TD Randall, I Sanz, AF Rosenberg, FE Lund | 11/04/2023 |
Communications biology |
JR Rose, B Akdogan-Ozdilek, AR Rahmberg, MD Powell, SL Hicks, CD Scharer, JM Boss | 03/04/2023 |
Nature communications |
KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich | 24/03/2023 |
Frontiers in cellular neuroscience |
S Ferdous, DA Shelton, TE Getz, MA Chrenek, N L'Hernault, JT Sellers, VR Summers, PM Iuvone, JM Boss, JH Boatright, JM Nickerson | 01/01/2023 |
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells. ImmunoHorizons |
MD Powell, P Lu, DK Neeld, AK Kania, LMM George-Alexander, APR Bally, CD Scharer, JM Boss | 01/12/2022 |
Journal of immunology (Baltimore, Md. : 1950) |
JL Lobby, I Uddbäck, CD Scharer, T Mi, JM Boss, AR Thomsen, JP Christensen, JE Kohlmeier | 01/11/2022 |
Journal of immunology (Baltimore, Md. : 1950) |
JM Boss | 01/06/2022 |
Journal of immunology (Baltimore, Md. : 1950) |
GA Dale, DJ Wilkins, J Rowley, CD Scharer, CM Tipton, J Hom, JM Boss, V Corces, I Sanz, J Jacob | 01/05/2022 |
H3K27me3 Demethylase UTX Restrains Plasma Cell Formation. Journal of immunology (Baltimore, Md. : 1950) |
AK Kania, MJ Price, LE George-Alexander, DG Patterson, SL Hicks, CD Scharer, JM Boss | 15/04/2022 |
Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nature communications |
M Lee, JAG Hamilton, GR Talekar, AJ Ross, L Michael, M Rupji, B Dwivedi, SS Raikar, J Boss, CD Scharer, DK Graham, D DeRyckere, CC Porter, CJ Henry | 03/03/2022 |
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting. Life science alliance |
CJ Joyner, AM Ley, DC Nguyen, M Ali, A Corrado, C Tipton, CD Scharer, T Mi, MC Woodruff, J Hom, JM Boss, M Duan, G Gibson, D Roberts, J Andrews, S Lonial, I Sanz, FE Lee | 01/03/2022 |
Experimental hematology |
C Zhou, R Uluisik, JW Rowley, C David, CL Jones, CD Scharer, L Noetzli, MH Fisher, GD Kirkpatrick, K Bark, JM Boss, CJ Henry, EM Pietras, J Di Paola, CC Porter | 01/01/2022 |
Frontiers in cell and developmental biology |
M Lee, DK Geitgey, JAG Hamilton, JM Boss, CD Scharer, JM Spangle, KA Haynes, CJ Henry | 01/01/2022 |
Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation. ImmunoHorizons |
AK Kania, M Guo, CD Scharer, JM Boss | 08/12/2021 |
Journal of immunology (Baltimore, Md. : 1950) |
DG Patterson, AK Kania, MJ Price, JR Rose, CD Scharer, JM Boss | 01/10/2021 |
Epigenetic gene regulation in plasma cells. Immunological reviews |
DG Patterson, AK Kania, Z Zuo, CD Scharer, JM Boss | 01/09/2021 |
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa. Mucosal immunology |
A Corrado, RP Ramonell, MC Woodruff, C Tipton, S Wise, J Levy, J DelGaudio, ME Kuruvilla, KR Magliocca, D Tomar, S Garimalla, CD Scharer, JM Boss, H Wu, S Gumber, C Fucile, G Gibson, A Rosenberg, I Sanz, FE Lee | 01/09/2021 |
Journal of immunology (Baltimore, Md. : 1950) |
P Majumder, JT Lee, BG Barwick, DG Patterson, APR Bally, CD Scharer, JM Boss | 01/05/2021 |
Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation. Journal of immunology (Baltimore, Md. : 1950) |
MJ Price, CD Scharer, AK Kania, TD Randall, JM Boss | 01/04/2021 |
Frontiers in immunology |
MA Rivas, C Durmaz, A Kloetgen, CR Chin, Z Chen, B Bhinder, A Koren, AD Viny, CD Scharer, JM Boss, O Elemento, CE Mason, AM Melnick | 01/01/2021 |
ImmunoHorizons |
CD Scharer, KA Fortner, JA Dragon, S Tighe, JM Boss, RC Budd | 23/10/2020 |
Human molecular genetics |
GAS Inglis, Y Zhou, DG Patterson, CD Scharer, Y Han, JM Boss, Z Wen, A Escayg | 29/08/2020 |
Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nature communications |
CD Scharer, DG Patterson, T Mi, MJ Price, SL Hicks, JM Boss | 10/08/2020 |
PLoS pathogens |
CM Collins, CD Scharer, TJ Murphy, JM Boss, SH Speck | 01/04/2020 |
Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells. Nature immunology |
SL Hayward, CD Scharer, EK Cartwright, S Takamura, ZT Li, JM Boss, JE Kohlmeier | 01/03/2020 |
A super enhancer controls expression and chromatin architecture within the MHC class II locus. The Journal of experimental medicine |
P Majumder, JT Lee, AR Rahmberg, G Kumar, T Mi, CD Scharer, JM Boss | 03/02/2020 |
PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis. Journal of immunology (Baltimore, Md. : 1950) |
APR Bally, DK Neeld, P Lu, P Majumder, Y Tang, BG Barwick, Q Wang, JM Boss | 15/01/2020 |
Immunity |
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta, AV Patel, X Wang, D Tomar, MC Woodruff, Z Simon, R Bugrovsky, EL Blalock, CD Scharer, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold, JH Anolik, G Gibson, F Eun-Hyung Lee, JM Boss, FE Lund, I Sanz | 14/01/2020 |
Immunity |
AB Morris, CR Farley, DF Pinelli, LE Adams, MS Cragg, JM Boss, CD Scharer, M Fribourg, P Cravedi, PS Heeger, ML Ford | 14/01/2020 |
Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. Molecular cancer research : MCR |
S Chandrasekaran, M Sasaki, CD Scharer, HT Kissick, DG Patterson, KR Magliocca, JT Seykora, B Sapkota, DA Gutman, LA Cooper, GB Lesinski, EK Waller, SN Thomas, SV Kotenko, JM Boss, CS Moreno, RA Swerlick, BP Pollack | 01/12/2019 |
Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease. Immunological reviews |
KS Cashman, SA Jenks, MC Woodruff, D Tomar, CM Tipton, CD Scharer, F Eun-Hyung Lee, JM Boss, I Sanz | 01/11/2019 |
IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes. Journal of immunology (Baltimore, Md. : 1950) |
MJ Price, SL Hicks, JE Bradley, TD Randall, JM Boss, CD Scharer | 15/10/2019 |
LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development. Journal of immunology (Baltimore, Md. : 1950) |
RR Haines, CD Scharer, JL Lobby, JM Boss | 01/10/2019 |
Epigenetic programming underpins B cell dysfunction in human SLE. Nature immunology |
CD Scharer, EL Blalock, T Mi, BG Barwick, SA Jenks, T Deguchi, KS Cashman, BE Neary, DG Patterson, SL Hicks, A Khosroshahi, F Eun-Hyung Lee, C Wei, I Sanz, JM Boss | 01/08/2019 |
Immunity |
SL Stone, JN Peel, CD Scharer, CA Risley, DA Chisolm, MD Schultz, B Yu, A Ballesteros-Tato, W Wojciechowski, B Mousseau, RS Misra, A Hanidu, H Jiang, Z Qi, JM Boss, TD Randall, SR Brodeur, AW Goldrath, AS Weinmann, AF Rosenberg, FE Lund | 21/05/2019 |
eLife |
E Zumaquero, SL Stone, CD Scharer, SA Jenks, A Nellore, B Mousseau, A Rosal-Vela, D Botta, JE Bradley, W Wojciechowski, T Ptacek, MI Danila, JC Edberg, SL Bridges, RP Kimberly, WW Chatham, TR Schoeb, AF Rosenberg, JM Boss, I Sanz, FE Lund | 15/05/2019 |
The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation. Journal of immunology (Baltimore, Md. : 1950) |
RR Haines, BG Barwick, CD Scharer, P Majumder, TD Randall, JM Boss | 01/11/2018 |
Immunity |
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta, AV Patel, X Wang, D Tomar, MC Woodruff, Z Simon, R Bugrovsky, EL Blalock, CD Scharer, CM Tipton, C Wei, SS Lim, M Petri, TB Niewold, JH Anolik, G Gibson, FE Lee, JM Boss, FE Lund, I Sanz | 16/10/2018 |
Cell reports |
MJ Price, DG Patterson, CD Scharer, JM Boss | 12/06/2018 |
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nature communications |
BG Barwick, CD Scharer, RJ Martinez, MJ Price, AN Wein, RR Haines, APR Bally, JE Kohlmeier, JM Boss | 15/05/2018 |
Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nature communications |
CD Scharer, BG Barwick, M Guo, APR Bally, JM Boss | 27/04/2018 |
Journal of immunology (Baltimore, Md. : 1950) |
M Guo, MJ Price, DG Patterson, BG Barwick, RR Haines, AK Kania, JE Bradley, TD Randall, JM Boss, CD Scharer | 01/02/2018 |
LSD1 protects against hippocampal and cortical neurodegeneration. Nature communications |
MA Christopher, DA Myrick, BG Barwick, AK Engstrom, KA Porter-Stransky, JM Boss, D Weinshenker, AI Levey, DJ Katz | 09/10/2017 |
Journal of autoimmunity |
KA Fortner, JP Bond, JW Austin, JM Boss, RC Budd | 01/08/2017 |
Development (Cambridge, England) |
K Matsuda, T Mikami, S Oki, H Iida, M Andrabi, JM Boss, K Yamaguchi, S Shigenobu, H Kondoh | 01/06/2017 |
Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. Journal of immunology (Baltimore, Md. : 1950) |
CD Scharer, AP Bally, B Gandham, JM Boss | 15/03/2017 |
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. Journal of immunology (Baltimore, Md. : 1950) |
AP Bally, Y Tang, JT Lee, BG Barwick, R Martinez, BD Evavold, JM Boss | 01/01/2017 |
LRRK2 levels in immune cells are increased in Parkinson's disease. NPJ Parkinson's disease |
DA Cook, GT Kannarkat, AF Cintron, LM Butkovich, KB Fraser, J Chang, N Grigoryan, SA Factor, AB West, JM Boss, MG Tansey | 01/01/2017 |
Nature immunology |
BG Barwick, CD Scharer, APR Bally, JM Boss | 01/10/2016 |
ZBTB32 Restricts the Duration of Memory B Cell Recall Responses. Journal of immunology (Baltimore, Md. : 1950) |
A Jash, Y Wang, FJ Weisel, CD Scharer, JM Boss, MJ Shlomchik, D Bhattacharya | 15/08/2016 |
Scientific reports |
CD Scharer, EL Blalock, BG Barwick, RR Haines, C Wei, I Sanz, JM Boss | 01/06/2016 |
Genetic and Epigenetic Regulation of PD-1 Expression. Journal of immunology (Baltimore, Md. : 1950) |
AP Bally, JW Austin, JM Boss | 15/03/2016 |
NF-κB regulates PD-1 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950) |
AP Bally, P Lu, Y Tang, JW Austin, CD Scharer, R Ahmed, JM Boss | 01/05/2015 |
Nucleic acids research |
CD Scharer, NM Choi, BG Barwick, P Majumder, S Lohsen, JM Boss | 31/03/2015 |
NPJ Parkinson's disease |
GT Kannarkat, DA Cook, JK Lee, J Chang, J Chung, E Sandy, KC Paul, B Ritz, J Bronstein, SA Factor, JM Boss, MG Tansey | 01/01/2015 |
Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types. Genes and immunity |
S Lohsen, P Majumder, CD Scharer, BG Barwick, JW Austin, WM Zinzow-Kramer, JM Boss | 01/12/2014 |
Journal of immunology (Baltimore, Md. : 1950) |
JW Austin, P Lu, P Majumder, R Ahmed, JM Boss | 15/05/2014 |
Journal of immunology (Baltimore, Md. : 1950) |
P Majumder, CD Scharer, NM Choi, JM Boss | 15/04/2014 |
The Journal of experimental medicine |
P Lu, BA Youngblood, JW Austin, AU Mohammed, R Butler, R Ahmed, JM Boss | 10/03/2014 |
Transcriptional regulation of YWHAZ, the gene encoding 14-3-3ζ. PloS one |
A Kasinski, X Dong, FR Khuri, J Boss, H Fu | 01/01/2014 |
Global DNA methylation remodeling accompanies CD8 T cell effector function. Journal of immunology (Baltimore, Md. : 1950) |
CD Scharer, BG Barwick, BA Youngblood, R Ahmed, JM Boss | 15/09/2013 |
Journal of immunology (Baltimore, Md. : 1950) |
B Youngblood, A Noto, F Porichis, RS Akondy, ZM Ndhlovu, JW Austin, R Bordi, FA Procopio, T Miura, TM Allen, J Sidney, A Sette, BD Walker, R Ahmed, JM Boss, RP Sékaly, DE Kaufmann | 15/07/2013 |
PLoS genetics |
O Gokcumen, Q Zhu, LC Mulder, RC Iskow, C Austermann, CD Scharer, T Raj, JM Boss, S Sunyaev, A Price, B Stranger, V Simon, C Lee | 01/04/2013 |
The role of innate and adaptive immunity in Parkinson's disease. Journal of Parkinson's disease |
GT Kannarkat, JM Boss, MG Tansey | 01/01/2013 |
Journal of immunology (Baltimore, Md. : 1950) |
HS Yoon, CD Scharer, P Majumder, CW Davis, R Butler, W Zinzow-Kramer, I Skountzou, DG Koutsonanos, R Ahmed, JM Boss | 01/09/2012 |
Genes and immunity |
WM Zinzow-Kramer, AB Long, BA Youngblood, KM Rosenthal, R Butler, AU Mohammed, I Skountzou, R Ahmed, BD Evavold, JM Boss | 01/06/2012 |
Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene. PloS one |
NM Choi, JM Boss | 01/01/2012 |
Cohesin regulates MHC class II genes through interactions with MHC class II insulators. Journal of immunology (Baltimore, Md. : 1950) |
P Majumder, JM Boss | 15/10/2011 |
Immunity |
B Youngblood, KJ Oestreich, SJ Ha, J Duraiswamy, RS Akondy, EE West, Z Wei, P Lu, JW Austin, JL Riley, JM Boss, R Ahmed | 23/09/2011 |
DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture. Genes and immunity |
P Majumder, JM Boss | 01/06/2011 |
Nature immunology |
C Kao, KJ Oestreich, MA Paley, A Crawford, JM Angelosanto, MA Ali, AM Intlekofer, JM Boss, SL Reiner, AS Weinmann, EJ Wherry | 29/05/2011 |
Regulation of major histocompatibility complex class II genes. Current opinion in immunology |
NM Choi, P Majumder, JM Boss | 01/02/2011 |
Journal of molecular biology |
KM Laird, LL Briggs, JM Boss, MF Summers, CW Garvie | 15/10/2010 |
Molecular and cellular biology |
P Majumder, JM Boss | 01/09/2010 |
PU.1 binds to a distal regulatory element that is necessary for B cell-specific expression of CIITA. Journal of immunology (Baltimore, Md. : 1950) |
H Yoon, JM Boss | 01/05/2010 |
Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP. Proteins |
L Briggs, K Laird, JM Boss, CW Garvie | 15/08/2009 |
Journal of virology |
CM Collins, JM Boss, SH Speck | 01/07/2009 |
Yin yang 1 regulates the expression of snail through a distal enhancer. Molecular cancer research : MCR |
MB Palmer, P Majumder, JC Cooper, H Yoon, PA Wade, JM Boss | 01/02/2009 |
Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation. Photochemistry and photobiology |
BP Pollack, B Sapkota, JM Boss | 01/01/2009 |
Biochimica et biophysica acta |
CW Garvie, JM Boss | 01/12/2008 |
NFATc1 regulates PD-1 expression upon T cell activation. Journal of immunology (Baltimore, Md. : 1950) |
KJ Oestreich, H Yoon, R Ahmed, JM Boss | 01/10/2008 |
Journal of immunology (Baltimore, Md. : 1950) |
JM Boss | 01/07/2008 |
Nature immunology |
W Reith, JM Boss | 01/07/2008 |
The Journal of experimental medicine |
P Majumder, JA Gomez, BP Chadwick, JM Boss | 14/04/2008 |
The NLR gene family: a standard nomenclature. Immunity |
JP Ting, RC Lovering, ES Alnemri, J Bertin, JM Boss, BK Davis, RA Flavell, SE Girardin, A Godzik, JA Harton, HM Hoffman, JP Hugot, N Inohara, A Mackenzie, LJ Maltais, G Nunez, Y Ogura, LA Otten, D Philpott, JC Reed, W Reith, S Schreiber, V Steimle, PA Ward | 01/03/2008 |
Mentoring and networking: how to make it work. Nature immunology |
L Haynes, SL Adams, JM Boss | 01/01/2008 |