Leon Bernal-Mizrachi, MD
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Biography
Leon Bernal-Mizrachi, MD, is an associate professor in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Bernal serves as the Emory section chief of Hematology and Medical Oncology at Grady Health Systems. Board certified in medical oncology and internal medicine, he is a clinical member of the leukemia comprehensive care team treating patients at Grady.
Dr. Bernal-Mizrachi is a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.
Dr. Bernal-Mizrachi began his research career at the Miller School of Medicine at the University of Miami with Dr. Yeon Ahn. During his fellowship at Washington University in St. Louis, Missouri, Dr. Bernal-Mizrachi continued on his search to define the role of inflammation and cancer. Under Dr. Lee Ratner's mentorship, he identified a novel prosurvival mechanism of each NF-kB pathway, an inflammatory signal. These findings ignited his interest in these signals and their role in B cell development and cancer development. To take advantage of new technologies and explore new avenues in these pathways, Dr. Bernal-Mizrachi trained at Cold Spring Harbor in integrative statistical analysis of genome-scale data. This knowledge set the foundation for the current work in his laboratory at Emory.
In Colombia, South America, he was co-director of the city's Diabetes Program as part of Cali's City Public Health Service in 1998-1999.
Education
Dr. Leon Bernal-Mizrachi earned his medical degree at Universidad del Valle School of Medicine in Cali, Colombia. He completed his residency at the University of Miami followed by a postdoctoral fellowship in Lee Ratner's laboratory at Washington University School of Medicine in St. Louis in the Division of Molecular Oncology.
Titles & Roles
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Associate Professor, Department of Hematology and Medical OncologyEmory University School of Medicine
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Section Chief, Hematology and Medical OncologyGrady Health System
Professional Memberships
Research
The Bernal-Mizrachi laboratory is specialized in studying cancers of the immune system such as lymphomas or myelomas. Based on the premise that the cancer of each patient has unique characteristics, Dr. Bernal-Mizrachi's lab is focused on creating new technologies that allow matching each patient’s unique cancer growth signals with specific therapies that can block their cancer signal growth effect. Their studies have provided new genetic indicators that could guide doctors to select the best combination of therapies. In this regard, Dr. Bernal-Mizrachi's team has focused on the NF-kB signals, an important signal for lymphoma/myeloma development. In these signals, they have discovered novel genetic alterations, biological functions, and biomarkers that can guide the selection of proper therapies and support the design of new therapies. Ultimately, Dr. Bernal-Mizrachi's passion is to improve the outcome and reduce the toxicity of the therapies used to treat lymphomas and myelomas.
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Grants
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Grant Number Title 7UM1CA121947-15 AIDS Malignancy Consortium (AMC) Title/Journal Authors Publication Date American journal of hematology
JR Cerhan, MJ Maurer, BK Link, AL Feldman, TM Habermann, DL Jaye, WR Burack, TJ McDonnell, F Vega, JR Chapman, S Syrbu, KR Vij, G Inghirami, JP Leonard, L Bernal-Mizrachi, U Farooq, TE Witzig, GJ Weiner, Y Wang, JP Alderuccio, SL Slager, MC Larson, SM Riska, BJ Gysbers, JJ Lunde, TW Reicks, AA Ayers, CB O'Leary, KJ Yost, H Liu, GS Nowakowski, J Ruan, D Chihara, JL Koff, C Casulo, CA Thompson, JB Cohen, BS Kahl, LJ Nastoupil, IS Lossos, JW Friedberg, P Martin, CR Flowers 01/03/2024 Frontiers in oncology
PK Puvvula, L Martinez-Medina, M Cinar, L Feng, A Pisarev, A Johnson, L Bernal-Mizrachi 01/01/2024 Addressing the disparities: the approach to the African American patient with multiple myeloma.
Blood cancer journal
M Bhutani, BJ Blue, C Cole, AZ Badros, SZ Usmani, AK Nooka, L Bernal-Mizrachi, J Mikhael 18/12/2023 JCO oncology practice
Y Yu, N Brown Wade, AE Hwang, AK Nooka, MA Fiala, A Mohrbacher, ES Peters, K Pawlish, C Bock, DJ Van Den Berg, KA Rand, D Stram, DV Conti, D Auclair, GA Colditz, J Mehta, CA Haiman, H Terebelo, N Janakiraman, S Singhal, B Chiu, R Vij, L Bernal-Mizrachi, JA Zonder, CA Huff, S Lonial, RZ Orlowski, W Cozen, S Ailawadhi 01/10/2020 Journal of the National Cancer Institute
KR Yabroff, K Reeder-Hayes, J Zhao, MT Halpern, AM Lopez, L Bernal-Mizrachi, AB Collier, J Neuner, J Phillips, W Blackstock, M Patel 01/07/2020 JCO oncology practice
MA Curry, I Chineke, T Redelico, C Terrell, W Bell, D Flood, P Mishra, J LaFollette, S Power, L Bernal-Mizrachi 01/04/2020 JCO oncology practice
I Chineke, M Adams Curry, W Bell, D Flood, P Mishra, S Power, L Bernal-Mizrachi 01/03/2020 Blood advances
Z Du, N Weinhold, GC Song, KA Rand, DJ Van Den Berg, AE Hwang, X Sheng, V Hom, S Ailawadhi, AK Nooka, S Singhal, K Pawlish, ES Peters, C Bock, A Mohrbacher, A Stram, SI Berndt, WJ Blot, G Casey, VL Stevens, R Kittles, PJ Goodman, WR Diver, A Hennis, B Nemesure, EA Klein, BA Rybicki, JL Stanford, JS Witte, L Signorello, EM John, L Bernstein, AM Stroup, OW Stephens, M Zangari, F Van Rhee, A Olshan, W Zheng, JJ Hu, R Ziegler, SJ Nyante, SA Ingles, MF Press, JD Carpten, SJ Chanock, J Mehta, GA Colditz, J Wolf, TG Martin, M Tomasson, MA Fiala, H Terebelo, N Janakiraman, L Kolonel, KC Anderson, L Le Marchand, D Auclair, BC Chiu, E Ziv, D Stram, R Vij, L Bernal-Mizrachi, GJ Morgan, JA Zonder, CA Huff, S Lonial, RZ Orlowski, DV Conti, CA Haiman, W Cozen 14/01/2020 Blood cancer journal
TM Schmidt, BG Barwick, N Joseph, LT Heffner, CC Hofmeister, L Bernal, MV Dhodapkar, VA Gupta, DL Jaye, J Wu, S Goyal, Z Chen, LH Boise, S Lonial, AK Nooka, JL Kaufman 25/11/2019 Cancer letters
C Qu, K Kunkalla, A Vaghefi, JK Frederiksen, Y Liu, JR Chapman, M Blonska, L Bernal-Mizrachi, JP Alderuccio, IS Lossos, R Landgraf, F Vega 01/11/2018 Journal of oncology practice
TJ Redelico, SM Walton, J LaFollette, M Adams Curry, L Bernal-Mizrachi 01/07/2018 Leukemia
Y Gu, K Xu, C Torre, M Samur, BG Barwick, M Rupji, J Arora, P Neri, J Kaufman, A Nooka, L Bernal-Mizrachi, P Vertino, SY Sun, J Chen, N Munshi, H Fu, J Kowalski, LH Boise, S Lonial 01/03/2018 Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.
Cell
A Reddy, J Zhang, NS Davis, AB Moffitt, CL Love, A Waldrop, S Leppa, A Pasanen, L Meriranta, ML Karjalainen-Lindsberg, P Nørgaard, M Pedersen, AO Gang, E Høgdall, TB Heavican, W Lone, J Iqbal, Q Qin, G Li, SY Kim, J Healy, KL Richards, Y Fedoriw, L Bernal-Mizrachi, JL Koff, AD Staton, CR Flowers, O Paltiel, N Goldschmidt, M Calaminici, A Clear, J Gribben, E Nguyen, MB Czader, SL Ondrejka, A Collie, ED Hsi, E Tse, RKH Au-Yeung, YL Kwong, G Srivastava, WWL Choi, AM Evens, M Pilichowska, M Sengar, N Reddy, S Li, A Chadburn, LI Gordon, ES Jaffe, S Levy, R Rempel, T Tzeng, LE Happ, T Dave, D Rajagopalan, J Datta, DB Dunson, SS Dave 05/10/2017 Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.
Oncogene
X Guo, JL Koff, AB Moffitt, M Cinar, S Ramachandiran, Z Chen, JM Switchenko, M Mosunjac, SG Neill, KP Mann, M Bagirov, Y Du, Y Natkunam, HJ Khoury, MR Rossi, W Harris, CR Flowers, IS Lossos, LH Boise, SS Dave, J Kowalski, L Bernal-Mizrachi 20/07/2017 The Genetic Basis of Hepatosplenic T-cell Lymphoma.
Cancer discovery
M McKinney, AB Moffitt, P Gaulard, M Travert, L De Leval, A Nicolae, M Raffeld, ES Jaffe, S Pittaluga, L Xi, T Heavican, J Iqbal, K Belhadj, MH Delfau-Larue, V Fataccioli, MB Czader, IS Lossos, JR Chapman-Fredricks, KL Richards, Y Fedoriw, SL Ondrejka, ED Hsi, L Low, D Weisenburger, WC Chan, N Mehta-Shah, S Horwitz, L Bernal-Mizrachi, CR Flowers, AW Beaven, M Parihar, L Baseggio, M Parrens, A Moreau, P Sujobert, M Pilichowska, AM Evens, A Chadburn, RK Au-Yeung, G Srivastava, WW Choi, JR Goodlad, I Aurer, S Basic-Kinda, RD Gascoyne, NS Davis, G Li, J Zhang, D Rajagopalan, A Reddy, C Love, S Levy, Y Zhuang, J Datta, DB Dunson, SS Davé 01/04/2017 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
KA Rand, C Song, E Dean, DJ Serie, K Curtin, X Sheng, D Hu, CA Huff, L Bernal-Mizrachi, MH Tomasson, S Ailawadhi, S Singhal, K Pawlish, ES Peters, CH Bock, A Stram, DJ Van Den Berg, CK Edlund, DV Conti, T Zimmerman, AE Hwang, S Huntsman, J Graff, A Nooka, Y Kong, SL Pregja, SI Berndt, WJ Blot, J Carpten, G Casey, L Chu, WR Diver, VL Stevens, MR Lieber, PJ Goodman, AJ Hennis, AW Hsing, J Mehta, RA Kittles, S Kolb, EA Klein, C Leske, AB Murphy, B Nemesure, C Neslund-Dudas, SS Strom, R Vij, BA Rybicki, JL Stanford, LB Signorello, JS Witte, CB Ambrosone, P Bhatti, EM John, L Bernstein, W Zheng, AF Olshan, JJ Hu, RG Ziegler, SJ Nyante, EV Bandera, BM Birmann, SA Ingles, MF Press, D Atanackovic, MJ Glenn, LA Cannon-Albright, B Jones, G Tricot, TG Martin, SK Kumar, JL Wolf, SL Deming Halverson, N Rothman, AR Brooks-Wilson, SV Rajkumar, LN Kolonel, SJ Chanock, SL Slager, RK Severson, N Janakiraman, HR Terebelo, EE Brown, AJ De Roos, AF Mohrbacher, GA Colditz, GG Giles, JJ Spinelli, BC Chiu, NC Munshi, KC Anderson, J Levy, JA Zonder, RZ Orlowski, S Lonial, NJ Camp, CM Vachon, E Ziv, DO Stram, DJ Hazelett, CA Haiman, W Cozen 01/12/2016 Southern medical journal
C Bulka, LJ Nastoupil, JL Koff, L Bernal-Mizrachi, KC Ward, JN Williams, AR Bayakly, JM Switchenko, LA Waller, CR Flowers 01/10/2016 Gene integrated set profile analysis: a context-based approach for inferring biological endpoints.
Nucleic acids research
J Kowalski, B Dwivedi, S Newman, JM Switchenko, R Pauly, DA Gutman, J Arora, K Gandhi, K Ainslie, G Doho, Z Qin, CS Moreno, MR Rossi, PM Vertino, S Lonial, L Bernal-Mizrachi, LH Boise 20/04/2016 Journal of stem cell research & therapy
HD Yun, T Dossul, L Bernal-Mizrachi, J Switchenko, C Ndibe, A Ibraheem, MD Dixon, AA Langston, AK Nooka, CR Flowers, RD Pentz, EK Waller 01/01/2016 Oncoscience
J Zhang, D Medina-Cleghorn, L Bernal-Mizrachi, PM Bracci, A Hubbard, L Conde, J Riby, DK Nomura, CF Skibola 01/01/2016 International journal of cancer
S Ramachandiran, A Adon, X Guo, Y Wang, H Wang, Z Chen, J Kowalski, UR Sunay, AN Young, T Brown, JC Mar, Y Du, H Fu, KP Mann, Y Natkunam, LH Boise, HI Saavedra, IS Lossos, L Bernal-Mizrachi 15/05/2015 Leukemia & lymphoma
LJ Nastoupil, PJ Shenoy, A Ambinder, JL Koff, AK Nooka, EK Waller, A Langston, M Seward, JL Kaufman, L Bernal-Mizrachi, N King, MJ Lechowicz, S Lonial, R Sinha, CR Flowers 01/02/2015 A time to kill: targeting apoptosis in cancer.
International journal of molecular sciences
JL Koff, S Ramachandiran, L Bernal-Mizrachi 28/01/2015 International journal of cancer
C Zwick, G Held, M Auth, L Bernal-Mizrachi, JD Roback, S Sunay, S Iida, Y Kuroda, A Sakai, M Ziepert, R Ueda, M Pfreundschuh, KD Preuss 15/08/2014 Leukemia & lymphoma
Z Mitri, MT Siddiqui, F El Rassi, JT Holden, LT Heffner, A Langston, EK Waller, E Winton, M McLemore, L Bernal-Mizrachi, D Jaye, M Arellano, HJ Khoury 01/07/2014 Blood
Y Gu, JL Kaufman, L Bernal, C Torre, SM Matulis, RD Harvey, J Chen, SY Sun, LH Boise, S Lonial 22/05/2014 Cancer informatics
R Yang, L Chen, S Newman, K Gandhi, G Doho, CS Moreno, PM Vertino, L Bernal-Mizarchi, S Lonial, LH Boise, M Rossi, J Kowalski, ZS Qin 01/01/2014 Cancer
AG Antun, S Gleason, M Arellano, AA Langston, ML McLemore, M Gaddh, F el Rassi, L Bernal-Mizrachi, J Galipeau, LT Heffner, EF Winton, HJ Khoury 01/11/2013 Examining racial differences in diffuse large B-cell lymphoma presentation and survival.
Leukemia & lymphoma
CR Flowers, PJ Shenoy, U Borate, K Bumpers, T Douglas-Holland, N King, OW Brawley, J Lipscomb, MJ Lechowicz, R Sinha, RS Grover, L Bernal-Mizrachi, J Kowalski, W Donnellan, A The, V Reddy, DL Jaye, J Foran 01/02/2013 Genetic heterogeneity of diffuse large B-cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America
J Zhang, V Grubor, CL Love, A Banerjee, KL Richards, PA Mieczkowski, C Dunphy, W Choi, WY Au, G Srivastava, PL Lugar, DA Rizzieri, AS Lagoo, L Bernal-Mizrachi, KP Mann, C Flowers, K Naresh, A Evens, LI Gordon, M Czader, JI Gill, ED Hsi, Q Liu, A Fan, K Walsh, D Jima, LL Smith, AJ Johnson, JC Byrd, MA Luftig, T Ni, J Zhu, A Chadburn, S Levy, D Dunson, SS Dave 22/01/2013 The genetic landscape of mutations in Burkitt lymphoma.
Nature genetics
C Love, Z Sun, D Jima, G Li, J Zhang, R Miles, KL Richards, CH Dunphy, WW Choi, G Srivastava, PL Lugar, DA Rizzieri, AS Lagoo, L Bernal-Mizrachi, KP Mann, CR Flowers, KN Naresh, AM Evens, A Chadburn, LI Gordon, MB Czader, JI Gill, ED Hsi, A Greenough, AB Moffitt, M McKinney, A Banerjee, V Grubor, S Levy, DB Dunson, SS Dave 01/12/2012 The Journal of biological chemistry
AE Riek, J Oh, JE Sprague, A Timpson, L de las Fuentes, L Bernal-Mizrachi, KB Schechtman, C Bernal-Mizrachi 09/11/2012 Characteristics and outcomes of diffuse large B-cell lymphoma presenting in leukaemic phase.
British journal of haematology
D Muringampurath-John, DL Jaye, CR Flowers, D Saxe, Z Chen, MJ Lechowicz, DD Weisenburger, M Bast, ML Arellano, L Bernal-Mizrachi, LT Heffner, M McLemore, JL Kaufman, EF Winton, S Lonial, JO Armitage, HJ Khoury 01/09/2012 Leukemia research
S Ramachandiran, J Cain, A Liao, Y He, X Guo, LH Boise, H Fu, L Ratner, HJ Khoury, L Bernal-Mizrachi 01/06/2012 Infectious agents and cancer
J Zhang, V Grubor, CL Love, A Banerjee, KL Richards, P Miezcowski, CH Dunphy, WWL Choi, WY Auv, G Srivastava, PL Lugar, DA Rizzieri, AS Lagoo, L Bernal-Mizrachi, KP Mann, CR Flowers, KN Naresh, AM Evens, LI Gordon, MB Czader, JI Gill, ED Hsi, Q Liu, A Fan, K Walsh, DD Jima, M Luftig, T Ni, J Zhu, A Chadburn, S Levy, DB Dunson, SS Dave 19/04/2012 Leukemia & lymphoma
D Muringampurath-John, CR Flowers, M Toscano, C Zhengjia, JL Kaufman, M Arellano, L Bernal-Mizrachi, LT Heffner, MJ Lechowicz, M McLemore, E Winton, DL Jaye, S Lonial, HJ Khoury 01/04/2012 New Challenges in the Management of Diffuse Large B-Cell Lymphoma.
Treatment strategies. Hematology
CR Flowers, LJ Nastoupil, L Bernal-Mizrachi, AC Rose, R Sinha 01/01/2012 Prognostic significance of leukopenia at the time of diagnosis in acute myeloid leukemia.
Clinical lymphoma, myeloma & leukemia
M Arellano, L Bernal-Mizrachi, L Pan, M Tighiouart, L Souza, X Guo, M McLemore, L Lima, S Sunay, LT Heffner, Z Chen, GZ Chen, A Langston, E Winton, HJ Khoury 01/10/2011 Leukemia & lymphoma
LM Lima, K Sampat, S Assouline, D Saxe, S Nault, M Tighiouart, M McLemore, M Arellano, E Winton, L Bernal-Mizrachi, J Cortes, HJ Khoury 01/06/2011 Cancer
L Lima, L Bernal-Mizrachi, D Saxe, KP Mann, M Tighiouart, M Arellano, L Heffner, M McLemore, A Langston, E Winton, HJ Khoury 15/03/2011 Blood
DD Jima, J Zhang, C Jacobs, KL Richards, CH Dunphy, WW Choi, WY Au, G Srivastava, MB Czader, DA Rizzieri, AS Lagoo, PL Lugar, KP Mann, CR Flowers, L Bernal-Mizrachi, KN Naresh, AM Evens, LI Gordon, M Luftig, DR Friedman, JB Weinberg, MA Thompson, JI Gill, Q Liu, T How, V Grubor, Y Gao, A Patel, H Wu, J Zhu, GC Blobe, PE Lipsky, A Chadburn, SS Dave 02/12/2010 Circulation
J Oh, S Weng, SK Felton, S Bhandare, A Riek, B Butler, BM Proctor, M Petty, Z Chen, KB Schechtman, L Bernal-Mizrachi, C Bernal-Mizrachi 25/08/2009 Proceedings of the National Academy of Sciences of the United States of America
Z Li, J Zhao, Y Du, HR Park, SY Sun, L Bernal-Mizrachi, A Aitken, FR Khuri, H Fu 08/01/2008 Awards
Dr. Bernal-Mizrachi is a recipient of the following awards:
- Travel Grant award, American Society of Clinical Oncology, 2004
- Best Project/Presentation at the Eleventh Session of the Resident Scholarly Activity Program.
- University of Miami School of Medicine, Jackson Memorial Hospital, Florida, 2000
- Tulane University Award: Best Year Medical Student of the 5th year of Medicine, 1996
- "Santander Medal" to the 2nd-best Bachelor of the Year in Santa Librada High School
- Multiple Myeloma Research Foundation