Rebecca Arnold, PhD, MS

Research Program

Cell and Molecular Biology
Phone Number

404-778-4939
Email Address

rsarnol@emory.edu

Biography

Rebecca S. Arnold, PhD, MS, is an assistant professor of urology at Emory University School of Medicine. Dr. Arnold is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute. She currently directs the work of research specialists and medical students during the School of Medicine-sponsored Discovery Project in Dr. Petros' lab in addition to performing her own independent research. She is active in publishing and grant writing to support the Department's research mission.

Education

Dr. Arnold earned her PhD from Indiana University at Bloomington. She completed postdoctoral studies at Simon Fraser University in Burnaby, British Columbia, Canada, followed by postdoctoral studies at Emory University before joining the faculty.

Titles & Roles

Assistant Professor, Department of Urology

Emory University School of Medicine

Research

Dr. Arnold's research interests include prostate and kidney cancers and focus on reactive oxygen and nitrogen species and mitochondrial genetics. In addition, she is an integral member of the Emory Urology research team working on a test to screen and detect kidney cancer.

Publications

Dr. Arnold has lectured both regionally and nationally, and has authored multiple scientific journal articles.

Title/Journal	Authors	Publication Date
A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila. Genetics	JS Brockett, T Manalo, H Zein-Sabatto, J Lee, J Fang, P Chu, H Feng, D Patil, P Davidson, K Ogan, VA Master, JG Pattaras, DL Roberts, SH Bergquist, MA Reyna, JA Petros, DA Lerit, RS Arnold	03/04/2024
A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy. bioRxiv : the preprint server for biology	B Wu, S Tapadar, Z Ruan, CQ Sun, RS Arnold, JO Olugbami, A Johnston, U Arunsi, DA Gaul, JA Petros, T Kobayashi, DG Duda, AK Oyelere	28/03/2024
Discovery of 5'-Substituted 5-Fluoro-2'-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors. ACS pharmacology & translational science	M Dasari, SC Pelly, J Geng, HB Gold, N Pribut, SK Sharma, MP D'Erasmo, PW Bartsch, C Sun, K Toti, RS Arnold, JA Petros, L Xu, Y Jiang, EJ Miller, DC Liotta	12/05/2023
Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment. HGG advances	Y Jiang, TJ Meyers, AA Emeka, LF Cooley, PR Cooper, N Lancki, I Helenowski, L Kachuri, DW Lin, JL Stanford, LF Newcomb, S Kolb, A Finelli, NE Fleshner, M Komisarenko, JA Eastham, B Ehdaie, N Benfante, CJ Logothetis, JR Gregg, CA Perez, S Garza, J Kim, LS Marks, M Delfin, D Barsa, D Vesprini, LH Klotz, A Loblaw, A Mamedov, SL Goldenberg, CS Higano, M Spillane, E Wu, HB Carter, CP Pavlovich, M Mamawala, T Landis, PR Carroll, JM Chan, MR Cooperberg, JE Cowan, TM Morgan, J Siddiqui, R Martin, EA Klein, K Brittain, P Gotwald, DA Barocas, JR Dallmer, JB Gordetsky, P Steele, SD Kundu, J Stockdale, MJ Roobol, LDF Venderbos, MG Sanda, R Arnold, D Patil, CP Evans, MA Dall'Era, A Vij, AJ Costello, K Chow, NM Corcoran, S Rais-Bahrami, C Phares, DS Scherr, T Flynn, RJ Karnes, M Koch, CR Dhondt, JB Nelson, D McBride, MS Cookson, KL Stratton, S Farriester, E Hemken, WM Stadler, T Pera, D Banionyte, FJ Bianco, IH Lopez, S Loeb, SS Taneja, N Byrne, CL Amling, A Martinez, L Boileau, FD Gaylis, J Petkewicz, N Kirwen, BT Helfand, J Xu, DM Scholtens, WJ Catalona, JS Witte	13/01/2022
Urine-Based Metabolomics and Machine Learning Reveals Metabolites Associated with Renal Cell Carcinoma Stage. Cancers	OO Bifarin, DA Gaul, S Sah, RS Arnold, K Ogan, VA Master, DL Roberts, SH Bergquist, JA Petros, AS Edison, FM Fernández	13/12/2021
Machine Learning-Enabled Renal Cell Carcinoma Status Prediction Using Multiplatform Urine-Based Metabolomics. Journal of proteome research	OO Bifarin, DA Gaul, S Sah, RS Arnold, K Ogan, VA Master, DL Roberts, SH Bergquist, JA Petros, FM Fernández, AS Edison	02/07/2021
A panel of selected serum protein biomarkers for the detection of aggressive prostate cancer. Theranostics	J Song, S Ma, LJ Sokoll, RV Eguez, N Höti, H Zhang, P Mohr, R Dua, D Patil, KD May, S Williams, R Arnold, MG Sanda, DW Chan, Z Zhang	01/01/2021
Liver-Targeting Class I Selective Histone Deacetylase Inhibitors Potently Suppress Hepatocellular Tumor Growth as Standalone Agents. Cancers	S Tapadar, S Fathi, B Wu, CQ Sun, I Raji, SG Moore, RS Arnold, DA Gaul, JA Petros, AK Oyelere	23/10/2020
Molecular characteristics and markers of advanced clear cell renal cell carcinoma: Pitfalls due to intratumoral heterogeneity and identification of genetic alterations associated with metastasis. International journal of urology : official journal of the Japanese Urological Association	RC Obeng, RS Arnold, K Ogan, VA Master, JG Pattaras, JA Petros, AO Osunkoya	01/09/2020
The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression. Translational oncology	Z Li, C Sun, S Tao, AO Osunkoya, RS Arnold, JA Petros, X Zu, CS Moreno	01/04/2020
Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy. Journal of proteome research	CS Clendinen, DA Gaul, ME Monge, RS Arnold, AS Edison, JA Petros, FM Fernández	01/03/2019
Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor. Cancer biology & therapy	CQ Sun, RS Arnold, CL Hsieh, JR Dorin, F Lian, Z Li, JA Petros	01/01/2019
Correction: Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients. Oncotarget	B Grindel, Q Li, R Arnold, J Petros, M Zayzafoon, M Muldoon, J Stave, LW Chung, MC Farach-Carson	13/09/2016
Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo. Oncotarget	MY Bonner, I Karlsson, M Rodolfo, RS Arnold, E Vergani, JL Arbiser	15/03/2016
Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients. Oncotarget	B Grindel, Q Li, R Arnold, J Petros, M Zayzafoon, M Muldoon, J Stave, LW Chung, MC Farach-Carson	01/03/2016
A mitochondrial DNA mutation influences the apoptotic effect of statins on prostate cancer. The Prostate	Q Sun, RS Arnold, CQ Sun, JA Petros	01/12/2015
Bone metastasis in prostate cancer: Recurring mitochondrial DNA mutation reveals selective pressure exerted by the bone microenvironment. Bone	RS Arnold, SA Fedewa, M Goodman, AO Osunkoya, HT Kissick, C Morrissey, LD True, JA Petros	01/09/2015
Mitochondrial DNA mutations in prostate cancer bone metastases. Journal of nature and science	CG Keith, RS Arnold, JA Petros	01/08/2015
Solenopsin A and analogs exhibit ceramide-like biological activity. Vascular cell	I Karlsson, X Zhou, R Thomas, AT Smith, MY Bonner, P Bakshi, AK Banga, JP Bowen, G Qabaja, SL Ford, MD Ballard, KS Petersen, X Li, G Chen, B Ogretmen, J Zhang, EB Watkins, RS Arnold, JL Arbiser	01/01/2015
von Hippel-Lindau exonic methylation analysis using MALDI-TOF mass spectrometry. The Journal of urology	F Lian, S Sreedharan, RS Arnold, VA Master, K Ogan, JG Pattaras, DL Roberts, JA Petros	01/11/2014
Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells. BMC complementary and alternative medicine	LJ Burton, P Barnett, B Smith, RS Arnold, T Hudson, K Kundu, N Murthy, VA Odero-Marah	12/03/2014
An inherited heteroplasmic mutation in mitochondrial gene COI in a patient with prostate cancer alters reactive oxygen, reactive nitrogen and proliferation. BioMed research international	RS Arnold, Q Sun, CQ Sun, JC Richards, S O'Hearn, AO Osunkoya, DC Wallace, JA Petros	01/01/2013
Mitochondrial Cytochrome c Oxidase subunit 1 Sequence Variation in Prostate Cancer. Scientifica	TA Scott, R Arnold, JA Petros	01/01/2012
Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model. PloS one	N Makarova, C Zhao, Y Zhang, S Bhosle, S Suppiah, JM Rhea, N Kozyr, RS Arnold, H Ly, RJ Molinaro, TG Parslow, E Hunter, D Liotta, J Petros, JL Blackwell	06/04/2011
Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cells. Biochemical and biophysical research communications	P Barnett, RS Arnold, R Mezencev, LW Chung, M Zayzafoon, V Odero-Marah	07/01/2011
Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. Journal of virology	S Bhosle, S Suppiah, R Molinaro, Y Liang, R Arnold, W Diehl, N Makarova, J Blackwell, J Petros, D Liotta, E Hunter, H Ly	01/07/2010
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH. Urology	RS Arnold, NV Makarova, AO Osunkoya, S Suppiah, TA Scott, NA Johnson, SM Bhosle, D Liotta, E Hunter, FF Marshall, H Ly, RJ Molinaro, JL Blackwell, JA Petros	01/04/2010
Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment. The Prostate	RS Arnold, CQ Sun, JC Richards, G Grigoriev, IM Coleman, PS Nelson, CL Hsieh, JK Lee, Z Xu, A Rogatko, AO Osunkoya, M Zayzafoon, L Chung, JA Petros	01/01/2009

Awards

Dr. Arnold is the recipient of the Henry R. Mahler Memorial Award from Indiana University as well as multiple National Research Service Awards from the National Institute of Health (NIH).